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Suppressive Mechanisms Induced by Tregs in Celiac Disease

CD is a systemic immune-mediated disorder caused by the dietary gluten in individuals who are genetically susceptible to the disease. In fact, CD is a T cell-mediated immune disease in which gluten-derived peptides activate the lamina propria CD4(+) Teff cells, and these T-cell subsets can cause the...

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Autores principales: Asri, Nastaran, Rostami-Nejad, Mohammad, Barzegar, Mohammad, Nikzamir, Abdolrahim, Rezaei-Tavirani, Mostafa, Razzaghi, Mohammadreza, Zali, Mohammad Reza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Pasteur Institute of Iran 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7275623/
https://www.ncbi.nlm.nih.gov/pubmed/31952431
http://dx.doi.org/10.29252/ibj.24.3.140
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author Asri, Nastaran
Rostami-Nejad, Mohammad
Barzegar, Mohammad
Nikzamir, Abdolrahim
Rezaei-Tavirani, Mostafa
Razzaghi, Mohammadreza
Zali, Mohammad Reza
author_facet Asri, Nastaran
Rostami-Nejad, Mohammad
Barzegar, Mohammad
Nikzamir, Abdolrahim
Rezaei-Tavirani, Mostafa
Razzaghi, Mohammadreza
Zali, Mohammad Reza
author_sort Asri, Nastaran
collection PubMed
description CD is a systemic immune-mediated disorder caused by the dietary gluten in individuals who are genetically susceptible to the disease. In fact, CD is a T cell-mediated immune disease in which gluten-derived peptides activate the lamina propria CD4(+) Teff cells, and these T-cell subsets can cause the intestinal tissue damages. Also, there are additional subsets of CD4(+) T cells with suppressor functions. These subsets express the master transcription factor, FOXP3, and include Tr1 cells and CD4(+)CD25(+) Tregs, which are the main population involved in maintaining the peripheral tolerance, preventing the autoimmune diseases and limiting the chronic inflammatory diseases such as CD. The suppressive function of Tregs is important to maintain the immune homeostasis. This paper examined the features and the basic mechanisms used by Tregs to mediate the suppression in CD.
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spelling pubmed-72756232020-06-15 Suppressive Mechanisms Induced by Tregs in Celiac Disease Asri, Nastaran Rostami-Nejad, Mohammad Barzegar, Mohammad Nikzamir, Abdolrahim Rezaei-Tavirani, Mostafa Razzaghi, Mohammadreza Zali, Mohammad Reza Iran Biomed J Review Article CD is a systemic immune-mediated disorder caused by the dietary gluten in individuals who are genetically susceptible to the disease. In fact, CD is a T cell-mediated immune disease in which gluten-derived peptides activate the lamina propria CD4(+) Teff cells, and these T-cell subsets can cause the intestinal tissue damages. Also, there are additional subsets of CD4(+) T cells with suppressor functions. These subsets express the master transcription factor, FOXP3, and include Tr1 cells and CD4(+)CD25(+) Tregs, which are the main population involved in maintaining the peripheral tolerance, preventing the autoimmune diseases and limiting the chronic inflammatory diseases such as CD. The suppressive function of Tregs is important to maintain the immune homeostasis. This paper examined the features and the basic mechanisms used by Tregs to mediate the suppression in CD. Pasteur Institute of Iran 2020-05 2020-01-18 /pmc/articles/PMC7275623/ /pubmed/31952431 http://dx.doi.org/10.29252/ibj.24.3.140 Text en This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Asri, Nastaran
Rostami-Nejad, Mohammad
Barzegar, Mohammad
Nikzamir, Abdolrahim
Rezaei-Tavirani, Mostafa
Razzaghi, Mohammadreza
Zali, Mohammad Reza
Suppressive Mechanisms Induced by Tregs in Celiac Disease
title Suppressive Mechanisms Induced by Tregs in Celiac Disease
title_full Suppressive Mechanisms Induced by Tregs in Celiac Disease
title_fullStr Suppressive Mechanisms Induced by Tregs in Celiac Disease
title_full_unstemmed Suppressive Mechanisms Induced by Tregs in Celiac Disease
title_short Suppressive Mechanisms Induced by Tregs in Celiac Disease
title_sort suppressive mechanisms induced by tregs in celiac disease
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7275623/
https://www.ncbi.nlm.nih.gov/pubmed/31952431
http://dx.doi.org/10.29252/ibj.24.3.140
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