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Suppressive Mechanisms Induced by Tregs in Celiac Disease
CD is a systemic immune-mediated disorder caused by the dietary gluten in individuals who are genetically susceptible to the disease. In fact, CD is a T cell-mediated immune disease in which gluten-derived peptides activate the lamina propria CD4(+) Teff cells, and these T-cell subsets can cause the...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Pasteur Institute of Iran
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7275623/ https://www.ncbi.nlm.nih.gov/pubmed/31952431 http://dx.doi.org/10.29252/ibj.24.3.140 |
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author | Asri, Nastaran Rostami-Nejad, Mohammad Barzegar, Mohammad Nikzamir, Abdolrahim Rezaei-Tavirani, Mostafa Razzaghi, Mohammadreza Zali, Mohammad Reza |
author_facet | Asri, Nastaran Rostami-Nejad, Mohammad Barzegar, Mohammad Nikzamir, Abdolrahim Rezaei-Tavirani, Mostafa Razzaghi, Mohammadreza Zali, Mohammad Reza |
author_sort | Asri, Nastaran |
collection | PubMed |
description | CD is a systemic immune-mediated disorder caused by the dietary gluten in individuals who are genetically susceptible to the disease. In fact, CD is a T cell-mediated immune disease in which gluten-derived peptides activate the lamina propria CD4(+) Teff cells, and these T-cell subsets can cause the intestinal tissue damages. Also, there are additional subsets of CD4(+) T cells with suppressor functions. These subsets express the master transcription factor, FOXP3, and include Tr1 cells and CD4(+)CD25(+) Tregs, which are the main population involved in maintaining the peripheral tolerance, preventing the autoimmune diseases and limiting the chronic inflammatory diseases such as CD. The suppressive function of Tregs is important to maintain the immune homeostasis. This paper examined the features and the basic mechanisms used by Tregs to mediate the suppression in CD. |
format | Online Article Text |
id | pubmed-7275623 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Pasteur Institute of Iran |
record_format | MEDLINE/PubMed |
spelling | pubmed-72756232020-06-15 Suppressive Mechanisms Induced by Tregs in Celiac Disease Asri, Nastaran Rostami-Nejad, Mohammad Barzegar, Mohammad Nikzamir, Abdolrahim Rezaei-Tavirani, Mostafa Razzaghi, Mohammadreza Zali, Mohammad Reza Iran Biomed J Review Article CD is a systemic immune-mediated disorder caused by the dietary gluten in individuals who are genetically susceptible to the disease. In fact, CD is a T cell-mediated immune disease in which gluten-derived peptides activate the lamina propria CD4(+) Teff cells, and these T-cell subsets can cause the intestinal tissue damages. Also, there are additional subsets of CD4(+) T cells with suppressor functions. These subsets express the master transcription factor, FOXP3, and include Tr1 cells and CD4(+)CD25(+) Tregs, which are the main population involved in maintaining the peripheral tolerance, preventing the autoimmune diseases and limiting the chronic inflammatory diseases such as CD. The suppressive function of Tregs is important to maintain the immune homeostasis. This paper examined the features and the basic mechanisms used by Tregs to mediate the suppression in CD. Pasteur Institute of Iran 2020-05 2020-01-18 /pmc/articles/PMC7275623/ /pubmed/31952431 http://dx.doi.org/10.29252/ibj.24.3.140 Text en This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Asri, Nastaran Rostami-Nejad, Mohammad Barzegar, Mohammad Nikzamir, Abdolrahim Rezaei-Tavirani, Mostafa Razzaghi, Mohammadreza Zali, Mohammad Reza Suppressive Mechanisms Induced by Tregs in Celiac Disease |
title | Suppressive Mechanisms Induced by Tregs in Celiac Disease |
title_full | Suppressive Mechanisms Induced by Tregs in Celiac Disease |
title_fullStr | Suppressive Mechanisms Induced by Tregs in Celiac Disease |
title_full_unstemmed | Suppressive Mechanisms Induced by Tregs in Celiac Disease |
title_short | Suppressive Mechanisms Induced by Tregs in Celiac Disease |
title_sort | suppressive mechanisms induced by tregs in celiac disease |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7275623/ https://www.ncbi.nlm.nih.gov/pubmed/31952431 http://dx.doi.org/10.29252/ibj.24.3.140 |
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