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Association of carotid intima-media thickness with the risk of sudden sensorineural hearing loss

Cardiovascular factors are associated with the pathophysiological features and risk of sudden sensorineural hearing loss (SSNHL). However, little is known about the link between carotid intima-media thickness (IMT), SSNHL risk, and their respective treatment outcomes. In this study, we retrospective...

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Autores principales: Ho, Chun-Hsien, Tan, Teng-Yeow, Hwang, Chung-Feng, Lin, Wei-Che, Wu, Ching-Nung, Yang, Chao-Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PeerJ Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7275684/
https://www.ncbi.nlm.nih.gov/pubmed/32547881
http://dx.doi.org/10.7717/peerj.9276
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author Ho, Chun-Hsien
Tan, Teng-Yeow
Hwang, Chung-Feng
Lin, Wei-Che
Wu, Ching-Nung
Yang, Chao-Hui
author_facet Ho, Chun-Hsien
Tan, Teng-Yeow
Hwang, Chung-Feng
Lin, Wei-Che
Wu, Ching-Nung
Yang, Chao-Hui
author_sort Ho, Chun-Hsien
collection PubMed
description Cardiovascular factors are associated with the pathophysiological features and risk of sudden sensorineural hearing loss (SSNHL). However, little is known about the link between carotid intima-media thickness (IMT), SSNHL risk, and their respective treatment outcomes. In this study, we retrospectively reviewed 47 SSNHL cases and 33 control subjects from a single medical center and compared their demographic data and clinical characteristics, including their carotid IMT and audiological data. Of the 80 enrolled subjects, the proportion of those with high carotid IMT was greater in the SSNHL group (53.2%) than in the control group (21.2%), with an odds ratio (OR) of 4.22 (95% confidence interval (CI) [1.53–11.61], P = 0.004). Notably, high carotid IMT was more common in female SSNHL patients than females in the control group (54.2% vs. 12.5%; OR, 8.27 (95% CI [1.53–44.62]), P = 0.008), particularly in female patients ≥50 years of age (75% vs. 25%; OR, 9.0 (95% CI [1.27–63.9]), P = 0.032). The multivariate regression analyses showed the association between high carotid IMT and SSNHL with an adjusted OR of 4.655 (95% CI [1.348–16.076], P = 0.015), particularly in female SSNHL patients (adjusted OR, 9.818 (95% CI [1.064–90.587], P = 0.044). The carotid IMT was not associated with the treatment outcomes of SSNHL. Our results indicate that early-stage atherosclerosis may be associated with SSNHL, particularly in female patients more than 50 years old.
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spelling pubmed-72756842020-06-15 Association of carotid intima-media thickness with the risk of sudden sensorineural hearing loss Ho, Chun-Hsien Tan, Teng-Yeow Hwang, Chung-Feng Lin, Wei-Che Wu, Ching-Nung Yang, Chao-Hui PeerJ Cardiology Cardiovascular factors are associated with the pathophysiological features and risk of sudden sensorineural hearing loss (SSNHL). However, little is known about the link between carotid intima-media thickness (IMT), SSNHL risk, and their respective treatment outcomes. In this study, we retrospectively reviewed 47 SSNHL cases and 33 control subjects from a single medical center and compared their demographic data and clinical characteristics, including their carotid IMT and audiological data. Of the 80 enrolled subjects, the proportion of those with high carotid IMT was greater in the SSNHL group (53.2%) than in the control group (21.2%), with an odds ratio (OR) of 4.22 (95% confidence interval (CI) [1.53–11.61], P = 0.004). Notably, high carotid IMT was more common in female SSNHL patients than females in the control group (54.2% vs. 12.5%; OR, 8.27 (95% CI [1.53–44.62]), P = 0.008), particularly in female patients ≥50 years of age (75% vs. 25%; OR, 9.0 (95% CI [1.27–63.9]), P = 0.032). The multivariate regression analyses showed the association between high carotid IMT and SSNHL with an adjusted OR of 4.655 (95% CI [1.348–16.076], P = 0.015), particularly in female SSNHL patients (adjusted OR, 9.818 (95% CI [1.064–90.587], P = 0.044). The carotid IMT was not associated with the treatment outcomes of SSNHL. Our results indicate that early-stage atherosclerosis may be associated with SSNHL, particularly in female patients more than 50 years old. PeerJ Inc. 2020-06-03 /pmc/articles/PMC7275684/ /pubmed/32547881 http://dx.doi.org/10.7717/peerj.9276 Text en © 2020 Ho et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited.
spellingShingle Cardiology
Ho, Chun-Hsien
Tan, Teng-Yeow
Hwang, Chung-Feng
Lin, Wei-Che
Wu, Ching-Nung
Yang, Chao-Hui
Association of carotid intima-media thickness with the risk of sudden sensorineural hearing loss
title Association of carotid intima-media thickness with the risk of sudden sensorineural hearing loss
title_full Association of carotid intima-media thickness with the risk of sudden sensorineural hearing loss
title_fullStr Association of carotid intima-media thickness with the risk of sudden sensorineural hearing loss
title_full_unstemmed Association of carotid intima-media thickness with the risk of sudden sensorineural hearing loss
title_short Association of carotid intima-media thickness with the risk of sudden sensorineural hearing loss
title_sort association of carotid intima-media thickness with the risk of sudden sensorineural hearing loss
topic Cardiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7275684/
https://www.ncbi.nlm.nih.gov/pubmed/32547881
http://dx.doi.org/10.7717/peerj.9276
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