Cargando…

Ginsenoside panaxatriol reverses TNBC paclitaxel resistance by inhibiting the IRAK1/NF-κB and ERK pathways

BACKGROUND: Paclitaxel (PTX) resistance is a major obstacle in the treatment of triple-negative breast cancer (TNBC). Previously, we have reported that interleukin-1 receptor-associated kinase 1 (IRAK1) and its downstream pathways are associated with PTX resistance in TNBC cells. In this study, we s...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Panpan, Song, Dan, Wan, Danhong, Li, Lingyu, Mei, Wenhui, Li, Xiaoyun, Han, Li, Zhu, Xiaofeng, Yang, Li, Cai, Yu, Zhang, Ronghua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	PeerJ Inc. 2020
Materias:	Molecular Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7275687/ https://www.ncbi.nlm.nih.gov/pubmed/32547883 http://dx.doi.org/10.7717/peerj.9281

Ejemplares similares

Anti-platelet activity of panaxatriol saponins is mediated by suppression of intracellular calcium mobilization and ERK2/p38 activation
por: Qi, Hongyi, et al.
Publicado: (2016)

Panaxadiol and Panaxatriol Derivatives as Anti-Hepatitis B Virus Inhibitors
por: Chen, Hao, et al.
Publicado: (2014)

Dimethyl Fumarate Induces Apoptosis via Inhibition of NF-κB and Enhances the Effect of Paclitaxel and Adriamycin in Human TNBC Cells
por: Tsurushima, Katsumasa, et al.
Publicado: (2022)

miR-330–5p in Small Extracellular Vesicles Derived From Plastrum testudinis-Preconditioned Bone Mesenchymal Stem Cells Attenuates Osteogenesis by Modulating Wnt/β-Catenin Signaling
por: Li, Xiaoyun, et al.
Publicado: (2021)

Inhibition of IRAK 1/4 alleviates colitis by inhibiting TLR 4/NF-κB pathway and protecting the intestinal barrier
por: Yan, Bo, et al.
Publicado: (2022)

Panaxatriol saponins promotes angiogenesis and enhances cerebral perfusion after ischemic stroke in rats
por: Hui, Zhen, et al.
Publicado: (2017)

Elevated expression of the rhythm gene NFIL3 promotes the progression of TNBC by activating NF-κB signaling through suppression of NFKBIA transcription
por: Yang, Weiwei, et al.
Publicado: (2022)

Tolerogenic dendritic cells and TLR4/IRAK4/NF-κB signaling pathway in allergic rhinitis
por: Kang, Chenglin, et al.
Publicado: (2023)

Saikosaponin-b2 Inhibits Primary Liver Cancer by Regulating the STK4/IRAK1/NF-κB Pathway
por: Lei, Chanhao, et al.
Publicado: (2023)

Inhibition of ERK signaling for treatment of ERRα positive TNBC
por: Musheyev, David, et al.
Publicado: (2023)

A Pan-Cancer Analysis of IRAK1 Expression and Their Association With Immunotherapy Response
por: Liu, Mengmeng, et al.
Publicado: (2022)

Antimetastatic Therapies of the Polysulfide Diallyl Trisulfide against Triple-Negative Breast Cancer (TNBC) via Suppressing MMP2/9 by Blocking NF-κB and ERK/MAPK Signaling Pathways
por: Liu, Yuping, et al.
Publicado: (2015)

The anti-platelet activity of panaxadiol fraction and panaxatriol fraction of Korean Red Ginseng in vitro and ex vivo
por: Lee, Yuan Yee, et al.
Publicado: (2023)

Dingchuan tang essential oil inhibits the production of inflammatory mediators via suppressing the IRAK/NF-κB, IRAK/AP-1, and TBK1/IRF3 pathways in lipopolysaccharide-stimulated RAW264.7 cells
por: Zhang, Yi, et al.
Publicado: (2018)

Investigation of TNBC in vitro Antiproliferative Effects of Versatile Pirrolo[1,2-a]quinoxaline Compounds
por: Perri, Mariarita, et al.
Publicado: (2019)

Immunosuppression through constitutively activated NF-κB signalling in human ovarian cancer and its reversal by an NF-κB inhibitor
por: Nishio, H, et al.
Publicado: (2014)

IRAK1 is a therapeutic target that drives breast cancer metastasis and resistance to paclitaxel
por: Wee, Zhen Ning, et al.
Publicado: (2015)

Identification of upregulated NF-κB inhibitor alpha and IRAK3 targeting lncRNA following intracranial aneurysm rupture-induced subarachnoid hemorrhage
por: Leng, Wei, et al.
Publicado: (2021)

MicroRNA-146a negatively regulates inflammation via the IRAK1/TRAF6/NF-κB signaling pathway in dry eye
por: Han, Ruifang, et al.
Publicado: (2023)

IRAK1 Duplication in MECP2 Duplication Syndrome Does Not Increase Canonical NF-κB–Induced Inflammation
por: Gottschalk, Ilona, et al.
Publicado: (2022)

NF-κB Signaling Pathway Confers Neuroblastoma Cells Migration and Invasion Ability via the Regulation of CXCR4
por: Zhi, Yunlai, et al.
Publicado: (2014)

Schizandrin C regulates lipid metabolism and inflammation in liver fibrosis by NF-κB and p38/ERK MAPK signaling pathways
por: Chen, Panpan, et al.
Publicado: (2023)

Overexpression of IκB⍺ modulates NF-κB activation of inflammatory target gene expression
por: Downton, Polly, et al.
Publicado: (2023)

Expression of COX-2, NF-κB-p65, NF-κB-p50 and IKKα in malignant and adjacent normal human colorectal tissue
por: Charalambous, M P, et al.
Publicado: (2009)

Mild hypothermia improves brain injury in rats with intracerebral hemorrhage by inhibiting IRAK2/NF‐κB signaling pathway
por: Shi, Hui, et al.
Publicado: (2020)

Pre-treatment with the CDK4/6 inhibitor palbociclib improves the efficacy of paclitaxel in TNBC cells
por: Cretella, Daniele, et al.
Publicado: (2019)

FMNL2 destabilises COMMD10 to activate NF-κB pathway in invasion and metastasis of colorectal cancer
por: Yang, S S, et al.
Publicado: (2017)

MiR-27a Modulates Radiosensitivity of Triple-Negative Breast Cancer (TNBC) Cells by Targeting CDC27
por: Ren, Yong-qiang, et al.
Publicado: (2015)

Irak : cinco años después /
por: Rosas, María Cristina
Publicado: (2008)

Neural Functions Play Different Roles in Triple Negative Breast Cancer (TNBC) and non-TNBC
por: Tan, Renbo, et al.
Publicado: (2020)

Dysregulation of NF-κB-Associated LncRNAs in Autism Spectrum Disorder
por: Honarmand Tamizkar, Kasra, et al.
Publicado: (2021)

NF-κB in neurodegenerative diseases: Recent evidence from human genetics
por: Kaltschmidt, Barbara, et al.
Publicado: (2022)

Correction: Corrigendum: IRAK1 is a therapeutic target that drives breast cancer metastasis and resistance to paclitaxel
por: Wee, Zhen Ning, et al.
Publicado: (2015)

Panaxatriol Saponins Attenuated Oxygen-Glucose Deprivation Injury in PC12 Cells via Activation of PI3K/Akt and Nrf2 Signaling Pathway
por: Huang, Yongliang, et al.
Publicado: (2014)

1-Chromonyl-5-Imidazolylpentadienone Demonstrates Anti-Cancer Action against TNBC and Exhibits Synergism with Paclitaxel
por: Modi, Karan, et al.
Publicado: (2020)

Pretreatment with Panaxatriol Saponin Attenuates Mitochondrial Apoptosis and Oxidative Stress to Facilitate Treatment of Myocardial Ischemia-Reperfusion Injury via the Regulation of Keap1/Nrf2 Activity
por: Yao, Huan, et al.
Publicado: (2022)

Effect of Combined Treatment Using Wilfortrine and Paclitaxel in Liver Cancer and Related Mechanism
por: Li, Shuzhen, et al.
Publicado: (2016)

A mechanistic review of chinese medicine polyphenols on bone formation and resorption
por: Li, Yan, et al.
Publicado: (2022)

IRAK1 and IRAK4 as emerging therapeutic targets in hematologic malignancies
por: Bennett, Joshua, et al.
Publicado: (2022)

Akt/Ezrin Tyr353/NF-κB pathway regulates EGF-induced EMT and metastasis in tongue squamous cell carcinoma
por: Wang, Y, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_l73ovmovli8srq39etuvuhg85k