Cargando…

Panaxynol, a bioactive component of American ginseng, targets macrophages and suppresses colitis in mice

Ulcerative colitis has a significant impact on the quality of life for the patients, and can substantially increase the risk of colon cancer in patients suffering long-term. Conventional treatments provide only modest relief paired with a high risk of side effects, while complementary and alternativ...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chaparala, Anusha, Poudyal, Deepak, Tashkandi, Hossam, Witalison, Erin E., Chumanevich, Alexander A., Hofseth, Jenna L., Nguyen, Ivy, Hardy, Olivia, Pittman, Douglas L., Wyatt, Michael D., Windust, Anthony, Murphy, Elizabeth A., Nagarkatti, Mitzi, Nagarkatti, Prakash, Hofseth, Lorne J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2020
Materias:	Priority Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7275787/ https://www.ncbi.nlm.nih.gov/pubmed/32547701 http://dx.doi.org/10.18632/oncotarget.27592

Ejemplares similares

Pharmacokinetics of Panaxynol in Mice
por: Tashkandi, Hossam, et al.
Publicado: (2020)

Molecules from American Ginseng Suppress Colitis through Nuclear Factor Erythroid-2-Related Factor 2
por: Chaparala, Anusha, et al.
Publicado: (2020)

Repurposing the anti-malarial drug, quinacrine: new anti-colitis properties
por: Chumanevich, Alexander A., et al.
Publicado: (2016)

Looking for the best anti-colitis medicine: A comparative analysis of current and prospective compounds
por: Chumanevich, Anastasiya A., et al.
Publicado: (2016)

A Limited Role of p53 on the Ability of a Hexane Fraction of American Ginseng to Suppress Mouse Colitis
por: Poudyal, Deepak, et al.
Publicado: (2012)

A Key Role of microRNA-29b for the Suppression of Colon Cancer Cell Migration by American Ginseng
por: Poudyal, Deepak, et al.
Publicado: (2013)

American ginseng suppresses inflammation and DNA damage associated with mouse colitis
por: Jin, Yu, et al.
Publicado: (2008)

Taming the beast within: resveratrol suppresses colitis and prevents colon cancer
por: Hofseth, Lorne J., et al.
Publicado: (2010)

Biosynthesis of Panaxynol and Panaxydol in Panax ginseng
por: Knispel, Nihat, et al.
Publicado: (2013)

Resveratrol-Mediated Attenuation of Staphylococcus aureus Enterotoxin B-Induced Acute Liver Injury Is Associated With Regulation of microRNA and Induction of Myeloid-Derived Suppressor Cells
por: Kadhim, Sabah, et al.
Publicado: (2018)

Molecular targeting of protein arginine deiminases to suppress colitis and prevent colon cancer
por: Witalison, Erin E., et al.
Publicado: (2015)

The Induction of microRNA-16 in Colon Cancer Cells by Protein Arginine Deiminase Inhibition Causes a p53-Dependent Cell Cycle Arrest
por: Cui, Xiangli, et al.
Publicado: (2013)

Altered gut microbiome in a mouse model of Gulf War Illness causes neuroinflammation and intestinal injury via leaky gut and TLR4 activation
por: Alhasson, Firas, et al.
Publicado: (2017)

Getting rigorous with scientific rigor
por: Hofseth, Lorne J
Publicado: (2018)

Skin Mast Cell-Driven Ceramides Drive Early Apoptosis in Pre-Symptomatic Eczema in Mice
por: Robida, Piper A., et al.
Publicado: (2021)

Acute and short-term administrations of delta-9-tetrahydrocannabinol modulate major gut metabolomic regulatory pathways in C57BL/6 mice
por: Oza, Megha, et al.
Publicado: (2019)

Genistein induces macrophage polarization and systemic cytokine to ameliorate experimental colitis
por: Abron, Jessicca D., et al.
Publicado: (2018)

miR-466a Targeting of TGF-β2 Contributes to FoxP3(+) Regulatory T Cell Differentiation in a Murine Model of Allogeneic Transplantation
por: Becker, William, et al.
Publicado: (2018)

Use of Cannabinoids to Treat Acute Respiratory Distress Syndrome and Cytokine Storm Associated with Coronavirus Disease-2019
por: Nagarkatti, Prakash, et al.
Publicado: (2020)

Targeting AhR as a Novel Therapeutic Modality against Inflammatory Diseases
por: Cannon, Alkeiver S., et al.
Publicado: (2021)

Activation of Aryl Hydrocarbon Receptor (AhR) Leads to Reciprocal Epigenetic Regulation of FoxP3 and IL-17 Expression and Amelioration of Experimental Colitis
por: Singh, Narendra P., et al.
Publicado: (2011)

Resveratrol Protects against Skin Inflammation through Inhibition of Mast Cell, Sphingosine Kinase-1, Stat3 and NF-κB p65 Signaling Activation in Mice
por: Carlucci, Christopher D., et al.
Publicado: (2023)

Role of Myeloid-Derived Suppressor Cells in Amelioration of Experimental Autoimmune Hepatitis Following Activation of TRPV1 Receptors by Cannabidiol
por: Hegde, Venkatesh L., et al.
Publicado: (2011)

Anandamide Attenuates Th-17 Cell-Mediated Delayed-Type Hypersensitivity Response by Triggering IL-10 Production and Consequent microRNA Induction
por: Jackson, Austin R., et al.
Publicado: (2014)

Prediction of Possible Biomarkers and Novel Pathways Conferring Risk to Post-Traumatic Stress Disorder
por: Chitrala, Kumaraswamy Naidu, et al.
Publicado: (2016)

Natural Indoles, Indole-3-Carbinol (I3C) and 3,3’-Diindolylmethane (DIM), Attenuate Staphylococcal Enterotoxin B-Mediated Liver Injury by Downregulating miR-31 Expression and Promoting Caspase-2-Mediated Apoptosis
por: Busbee, Philip B., et al.
Publicado: (2015)

From Suppressor T Cells to Regulatory T Cells: How the Journey that Began with the Discovery of the Toxic Effects of TCDD Led to Better Understanding of the Role of AhR in Immunoregulation
por: Prasad Singh, Narendra, et al.
Publicado: (2020)

Regulation of Intestinal Stem Cell Stemness by the Aryl Hydrocarbon Receptor and Its Ligands
por: Wisniewski, Paul J., et al.
Publicado: (2021)

Epigenetic Regulation of Cannabinoid-Mediated Attenuation of Inflammation and Its Impact on the Use of Cannabinoids to Treat Autoimmune Diseases
por: Holloman, Bryan Latrell, et al.
Publicado: (2021)

Role of Gut Microbiota in Cannabinoid-Mediated Suppression of Inflammation
por: Varsha, Kontham Kulangara, et al.
Publicado: (2022)

Immune and microRNA responses to Helicobacter muridarum infection and indole-3-carbinol during colitis
por: Alkarkoushi, Rasha Raheem, et al.
Publicado: (2020)

Cannabidiol Regulates Gene Expression in Encephalitogenic T cells Using Histone Methylation and noncoding RNA during Experimental Autoimmune Encephalomyelitis
por: Yang, Xiaoming, et al.
Publicado: (2019)

Activation of Cannabinoid Receptor 2 Prevents Colitis-Associated Colon Cancer through Myeloid Cell De-activation Upstream of IL-22 Production
por: Becker, William, et al.
Publicado: (2020)

Cannabidiol Attenuates Experimental Autoimmune Encephalomyelitis Model of Multiple Sclerosis Through Induction of Myeloid-Derived Suppressor Cells
por: Elliott, David M., et al.
Publicado: (2018)

Role of miRNA in the regulation of cannabidiol-mediated apoptosis in neuroblastoma cells
por: Alharris, Esraah, et al.
Publicado: (2019)

Analysis of the TP53 Deleterious Single Nucleotide Polymorphisms Impact on Estrogen Receptor Alpha-p53 Interaction: A Machine Learning Approach
por: Chitrala, Kumaraswamy Naidu, et al.
Publicado: (2019)

Comparative analysis of interactions between aryl hydrocarbon receptor ligand binding domain with its ligands: a computational study
por: Chitrala, Kumaraswamy Naidu, et al.
Publicado: (2018)

Cannabinoid Receptor 1 Blockade Attenuates Obesity and Adipose Tissue Type 1 Inflammation Through miR-30e-5p Regulation of Delta-Like-4 in Macrophages and Consequently Downregulation of Th1 Cells
por: Miranda, Kathryn, et al.
Publicado: (2019)

Combination of Cannabinoids, Δ9- Tetrahydrocannabinol and Cannabidiol, Ameliorates Experimental Multiple Sclerosis by Suppressing Neuroinflammation Through Regulation of miRNA-Mediated Signaling Pathways
por: Al-Ghezi, Zinah Zamil, et al.
Publicado: (2019)

The role of gut microbiota in shaping the relapse-remitting and chronic-progressive forms of multiple sclerosis in mouse models
por: Gandy, K. Alexa Orr, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_t5mfp3o2keccb5r0p3oifcfohn