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An OpenData portal to share COVID-19 drug repurposing data in real time
The National Center for Advancing Translational Sciences (NCATS) has developed an online open science data portal for its COVID-19 drug repurposing campaign – named OpenData – with the goal of making data across a range of SARS-CoV-2 related assays available in real-time. The assays developed cover...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7276055/ https://www.ncbi.nlm.nih.gov/pubmed/32511420 http://dx.doi.org/10.1101/2020.06.04.135046 |
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author | Brimacombe, Kyle R. Zhao, Tongan Eastman, Richard T. Hu, Xin Wang, Ke Backus, Mark Baljinnyam, Bolormaa Chen, Catherine Z. Chen, Lu Eicher, Tara Ferrer, Marc Fu, Ying Gorshkov, Kirill Guo, Hui Hanson, Quinlin M. Itkin, Zina Kales, Stephen C. Klumpp-Thomas, Carleen Lee, Emily M. Michael, Sam Mierzwa, Tim Patt, Andrew Pradhan, Manisha Renn, Alex Shinn, Paul Shrimp, Jonathan H. Viraktamath, Amit Wilson, Kelli M. Xu, Miao Zakharov, Alexey V. Zhu, Wei Zheng, Wei Simeonov, Anton Mathé, Ewy A. Lo, Donald C. Hall, Matthew D. Shen, Min |
author_facet | Brimacombe, Kyle R. Zhao, Tongan Eastman, Richard T. Hu, Xin Wang, Ke Backus, Mark Baljinnyam, Bolormaa Chen, Catherine Z. Chen, Lu Eicher, Tara Ferrer, Marc Fu, Ying Gorshkov, Kirill Guo, Hui Hanson, Quinlin M. Itkin, Zina Kales, Stephen C. Klumpp-Thomas, Carleen Lee, Emily M. Michael, Sam Mierzwa, Tim Patt, Andrew Pradhan, Manisha Renn, Alex Shinn, Paul Shrimp, Jonathan H. Viraktamath, Amit Wilson, Kelli M. Xu, Miao Zakharov, Alexey V. Zhu, Wei Zheng, Wei Simeonov, Anton Mathé, Ewy A. Lo, Donald C. Hall, Matthew D. Shen, Min |
author_sort | Brimacombe, Kyle R. |
collection | PubMed |
description | The National Center for Advancing Translational Sciences (NCATS) has developed an online open science data portal for its COVID-19 drug repurposing campaign – named OpenData – with the goal of making data across a range of SARS-CoV-2 related assays available in real-time. The assays developed cover a wide spectrum of the SARS-CoV-2 life cycle, including both viral and human (host) targets. In total, over 10,000 compounds are being tested in full concentration-response ranges from across multiple annotated small molecule libraries, including approved drug, repurposing candidates and experimental therapeutics designed to modulate a wide range of cellular targets. The goal is to support research scientists, clinical investigators and public health officials through open data sharing and analysis tools to expedite the development of SARS-CoV-2 interventions, and to prioritize promising compounds and repurposed drugs for further development in treating COVID-19. |
format | Online Article Text |
id | pubmed-7276055 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Cold Spring Harbor Laboratory |
record_format | MEDLINE/PubMed |
spelling | pubmed-72760552020-06-07 An OpenData portal to share COVID-19 drug repurposing data in real time Brimacombe, Kyle R. Zhao, Tongan Eastman, Richard T. Hu, Xin Wang, Ke Backus, Mark Baljinnyam, Bolormaa Chen, Catherine Z. Chen, Lu Eicher, Tara Ferrer, Marc Fu, Ying Gorshkov, Kirill Guo, Hui Hanson, Quinlin M. Itkin, Zina Kales, Stephen C. Klumpp-Thomas, Carleen Lee, Emily M. Michael, Sam Mierzwa, Tim Patt, Andrew Pradhan, Manisha Renn, Alex Shinn, Paul Shrimp, Jonathan H. Viraktamath, Amit Wilson, Kelli M. Xu, Miao Zakharov, Alexey V. Zhu, Wei Zheng, Wei Simeonov, Anton Mathé, Ewy A. Lo, Donald C. Hall, Matthew D. Shen, Min bioRxiv Article The National Center for Advancing Translational Sciences (NCATS) has developed an online open science data portal for its COVID-19 drug repurposing campaign – named OpenData – with the goal of making data across a range of SARS-CoV-2 related assays available in real-time. The assays developed cover a wide spectrum of the SARS-CoV-2 life cycle, including both viral and human (host) targets. In total, over 10,000 compounds are being tested in full concentration-response ranges from across multiple annotated small molecule libraries, including approved drug, repurposing candidates and experimental therapeutics designed to modulate a wide range of cellular targets. The goal is to support research scientists, clinical investigators and public health officials through open data sharing and analysis tools to expedite the development of SARS-CoV-2 interventions, and to prioritize promising compounds and repurposed drugs for further development in treating COVID-19. Cold Spring Harbor Laboratory 2020-06-05 /pmc/articles/PMC7276055/ /pubmed/32511420 http://dx.doi.org/10.1101/2020.06.04.135046 Text en http://creativecommons.org/licenses/by-nc-nd/4.0/It is made available under a CC-BY-NC-ND 4.0 International license (http://creativecommons.org/licenses/by-nc-nd/4.0/) . |
spellingShingle | Article Brimacombe, Kyle R. Zhao, Tongan Eastman, Richard T. Hu, Xin Wang, Ke Backus, Mark Baljinnyam, Bolormaa Chen, Catherine Z. Chen, Lu Eicher, Tara Ferrer, Marc Fu, Ying Gorshkov, Kirill Guo, Hui Hanson, Quinlin M. Itkin, Zina Kales, Stephen C. Klumpp-Thomas, Carleen Lee, Emily M. Michael, Sam Mierzwa, Tim Patt, Andrew Pradhan, Manisha Renn, Alex Shinn, Paul Shrimp, Jonathan H. Viraktamath, Amit Wilson, Kelli M. Xu, Miao Zakharov, Alexey V. Zhu, Wei Zheng, Wei Simeonov, Anton Mathé, Ewy A. Lo, Donald C. Hall, Matthew D. Shen, Min An OpenData portal to share COVID-19 drug repurposing data in real time |
title | An OpenData portal to share COVID-19 drug repurposing data in real time |
title_full | An OpenData portal to share COVID-19 drug repurposing data in real time |
title_fullStr | An OpenData portal to share COVID-19 drug repurposing data in real time |
title_full_unstemmed | An OpenData portal to share COVID-19 drug repurposing data in real time |
title_short | An OpenData portal to share COVID-19 drug repurposing data in real time |
title_sort | opendata portal to share covid-19 drug repurposing data in real time |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7276055/ https://www.ncbi.nlm.nih.gov/pubmed/32511420 http://dx.doi.org/10.1101/2020.06.04.135046 |
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