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Deceiving SARS-CoV-2 molecular-tropism clues – A combinational contemporary strategy
Several attempts to control the dreadfulness of SARS-CoV-2 are still underway. Based on the literature evidences we have speculated a prospective contemporary remedy, which was categorized into Specificity, Remedy, and a Conveyor. In which, pros and cons were discussed and inferred the possible alte...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier Ltd.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7276125/ https://www.ncbi.nlm.nih.gov/pubmed/32563970 http://dx.doi.org/10.1016/j.mehy.2020.109976 |
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author | Balaji, APB Bhuvaneswari, Srinivasan Kumar, D Nanda |
author_facet | Balaji, APB Bhuvaneswari, Srinivasan Kumar, D Nanda |
author_sort | Balaji, APB |
collection | PubMed |
description | Several attempts to control the dreadfulness of SARS-CoV-2 are still underway. Based on the literature evidences we have speculated a prospective contemporary remedy, which was categorized into Specificity, Remedy, and a Conveyor. In which, pros and cons were discussed and inferred the possible alternatives. (a) Specificity: Implicit to express the ACE2 receptors in conveyor cells to deceive SARS-CoV-2 from prepone targets. (b) Remedy: As depletion of pulmonary surfactants causes strong acute respiratory distress syndrome, we propose an entity of a cost-effective artificial surfactant system as a remedy to pulmonary complications. (c) Conveyor: We propose red blood cells (RBCs) as a conveyor with embedded artificial surfactant and protruding ACE2 receptors for the target-specific delivery. Overall we postulate focused insights by employing a combinational contemporary strategy to steer towards a prospective direction on combating SARS-CoV-2. |
format | Online Article Text |
id | pubmed-7276125 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Elsevier Ltd. |
record_format | MEDLINE/PubMed |
spelling | pubmed-72761252020-06-08 Deceiving SARS-CoV-2 molecular-tropism clues – A combinational contemporary strategy Balaji, APB Bhuvaneswari, Srinivasan Kumar, D Nanda Med Hypotheses Article Several attempts to control the dreadfulness of SARS-CoV-2 are still underway. Based on the literature evidences we have speculated a prospective contemporary remedy, which was categorized into Specificity, Remedy, and a Conveyor. In which, pros and cons were discussed and inferred the possible alternatives. (a) Specificity: Implicit to express the ACE2 receptors in conveyor cells to deceive SARS-CoV-2 from prepone targets. (b) Remedy: As depletion of pulmonary surfactants causes strong acute respiratory distress syndrome, we propose an entity of a cost-effective artificial surfactant system as a remedy to pulmonary complications. (c) Conveyor: We propose red blood cells (RBCs) as a conveyor with embedded artificial surfactant and protruding ACE2 receptors for the target-specific delivery. Overall we postulate focused insights by employing a combinational contemporary strategy to steer towards a prospective direction on combating SARS-CoV-2. Elsevier Ltd. 2020-11 2020-06-07 /pmc/articles/PMC7276125/ /pubmed/32563970 http://dx.doi.org/10.1016/j.mehy.2020.109976 Text en © 2020 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Balaji, APB Bhuvaneswari, Srinivasan Kumar, D Nanda Deceiving SARS-CoV-2 molecular-tropism clues – A combinational contemporary strategy |
title | Deceiving SARS-CoV-2 molecular-tropism clues – A combinational contemporary strategy |
title_full | Deceiving SARS-CoV-2 molecular-tropism clues – A combinational contemporary strategy |
title_fullStr | Deceiving SARS-CoV-2 molecular-tropism clues – A combinational contemporary strategy |
title_full_unstemmed | Deceiving SARS-CoV-2 molecular-tropism clues – A combinational contemporary strategy |
title_short | Deceiving SARS-CoV-2 molecular-tropism clues – A combinational contemporary strategy |
title_sort | deceiving sars-cov-2 molecular-tropism clues – a combinational contemporary strategy |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7276125/ https://www.ncbi.nlm.nih.gov/pubmed/32563970 http://dx.doi.org/10.1016/j.mehy.2020.109976 |
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