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Deceiving SARS-CoV-2 molecular-tropism clues – A combinational contemporary strategy

Several attempts to control the dreadfulness of SARS-CoV-2 are still underway. Based on the literature evidences we have speculated a prospective contemporary remedy, which was categorized into Specificity, Remedy, and a Conveyor. In which, pros and cons were discussed and inferred the possible alte...

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Detalles Bibliográficos
Autores principales: Balaji, APB, Bhuvaneswari, Srinivasan, Kumar, D Nanda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7276125/
https://www.ncbi.nlm.nih.gov/pubmed/32563970
http://dx.doi.org/10.1016/j.mehy.2020.109976
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author Balaji, APB
Bhuvaneswari, Srinivasan
Kumar, D Nanda
author_facet Balaji, APB
Bhuvaneswari, Srinivasan
Kumar, D Nanda
author_sort Balaji, APB
collection PubMed
description Several attempts to control the dreadfulness of SARS-CoV-2 are still underway. Based on the literature evidences we have speculated a prospective contemporary remedy, which was categorized into Specificity, Remedy, and a Conveyor. In which, pros and cons were discussed and inferred the possible alternatives. (a) Specificity: Implicit to express the ACE2 receptors in conveyor cells to deceive SARS-CoV-2 from prepone targets. (b) Remedy: As depletion of pulmonary surfactants causes strong acute respiratory distress syndrome, we propose an entity of a cost-effective artificial surfactant system as a remedy to pulmonary complications. (c) Conveyor: We propose red blood cells (RBCs) as a conveyor with embedded artificial surfactant and protruding ACE2 receptors for the target-specific delivery. Overall we postulate focused insights by employing a combinational contemporary strategy to steer towards a prospective direction on combating SARS-CoV-2.
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spelling pubmed-72761252020-06-08 Deceiving SARS-CoV-2 molecular-tropism clues – A combinational contemporary strategy Balaji, APB Bhuvaneswari, Srinivasan Kumar, D Nanda Med Hypotheses Article Several attempts to control the dreadfulness of SARS-CoV-2 are still underway. Based on the literature evidences we have speculated a prospective contemporary remedy, which was categorized into Specificity, Remedy, and a Conveyor. In which, pros and cons were discussed and inferred the possible alternatives. (a) Specificity: Implicit to express the ACE2 receptors in conveyor cells to deceive SARS-CoV-2 from prepone targets. (b) Remedy: As depletion of pulmonary surfactants causes strong acute respiratory distress syndrome, we propose an entity of a cost-effective artificial surfactant system as a remedy to pulmonary complications. (c) Conveyor: We propose red blood cells (RBCs) as a conveyor with embedded artificial surfactant and protruding ACE2 receptors for the target-specific delivery. Overall we postulate focused insights by employing a combinational contemporary strategy to steer towards a prospective direction on combating SARS-CoV-2. Elsevier Ltd. 2020-11 2020-06-07 /pmc/articles/PMC7276125/ /pubmed/32563970 http://dx.doi.org/10.1016/j.mehy.2020.109976 Text en © 2020 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Balaji, APB
Bhuvaneswari, Srinivasan
Kumar, D Nanda
Deceiving SARS-CoV-2 molecular-tropism clues – A combinational contemporary strategy
title Deceiving SARS-CoV-2 molecular-tropism clues – A combinational contemporary strategy
title_full Deceiving SARS-CoV-2 molecular-tropism clues – A combinational contemporary strategy
title_fullStr Deceiving SARS-CoV-2 molecular-tropism clues – A combinational contemporary strategy
title_full_unstemmed Deceiving SARS-CoV-2 molecular-tropism clues – A combinational contemporary strategy
title_short Deceiving SARS-CoV-2 molecular-tropism clues – A combinational contemporary strategy
title_sort deceiving sars-cov-2 molecular-tropism clues – a combinational contemporary strategy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7276125/
https://www.ncbi.nlm.nih.gov/pubmed/32563970
http://dx.doi.org/10.1016/j.mehy.2020.109976
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