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Can Maternal Autoantibodies Play an Etiological Role in ASD Development?

Autism spectrum disorder (ASD) is a heterogeneous condition with multiple etiologies and risk factors – both genetic and environmental. Recent data demonstrate that the immune system plays an important role in prenatal brain development. Deregulation of the immune system during embryonic development...

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Autores principales: Dudova, Iva, Horackova, Klara, Hrdlicka, Michal, Balastik, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7276202/
https://www.ncbi.nlm.nih.gov/pubmed/32581542
http://dx.doi.org/10.2147/NDT.S239504
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author Dudova, Iva
Horackova, Klara
Hrdlicka, Michal
Balastik, Martin
author_facet Dudova, Iva
Horackova, Klara
Hrdlicka, Michal
Balastik, Martin
author_sort Dudova, Iva
collection PubMed
description Autism spectrum disorder (ASD) is a heterogeneous condition with multiple etiologies and risk factors – both genetic and environmental. Recent data demonstrate that the immune system plays an important role in prenatal brain development. Deregulation of the immune system during embryonic development can lead to neurodevelopmental changes resulting in ASD. One of the potential etiologic factors in the development of ASD has been identified as the presence of maternal autoantibodies targeting fetal brain proteins. The type of ASD associated with the presence of maternal autoantibodies has been referred to as maternal antibodies related to ASD (MAR ASD). The link between maternal autoantibodies and ASD has been demonstrated in both clinical studies and animal models, but the exact mechanism of their action in the pathogenesis of ASD has not been clarified yet. Several protein targets of ASD-related maternal autoantibodies have been identified. Here, we discuss the role of microtubule-associated proteins of the collapsin response mediator protein (CRMP) family in neurodevelopment and ASD. CRMPs have been shown to integrate multiple signaling cascades regulating neuron growth, guidance or migration. Their targeting by maternal autoantibodies could change CRMP levels or distribution in the developing nervous system, leading to defects in axon growth/guidance, cortical migration, or dendritic projection, which could play an etiological role in ASD development. In addition, we discuss the future possibilities of MAR ASD treatment.
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spelling pubmed-72762022020-06-23 Can Maternal Autoantibodies Play an Etiological Role in ASD Development? Dudova, Iva Horackova, Klara Hrdlicka, Michal Balastik, Martin Neuropsychiatr Dis Treat Review Autism spectrum disorder (ASD) is a heterogeneous condition with multiple etiologies and risk factors – both genetic and environmental. Recent data demonstrate that the immune system plays an important role in prenatal brain development. Deregulation of the immune system during embryonic development can lead to neurodevelopmental changes resulting in ASD. One of the potential etiologic factors in the development of ASD has been identified as the presence of maternal autoantibodies targeting fetal brain proteins. The type of ASD associated with the presence of maternal autoantibodies has been referred to as maternal antibodies related to ASD (MAR ASD). The link between maternal autoantibodies and ASD has been demonstrated in both clinical studies and animal models, but the exact mechanism of their action in the pathogenesis of ASD has not been clarified yet. Several protein targets of ASD-related maternal autoantibodies have been identified. Here, we discuss the role of microtubule-associated proteins of the collapsin response mediator protein (CRMP) family in neurodevelopment and ASD. CRMPs have been shown to integrate multiple signaling cascades regulating neuron growth, guidance or migration. Their targeting by maternal autoantibodies could change CRMP levels or distribution in the developing nervous system, leading to defects in axon growth/guidance, cortical migration, or dendritic projection, which could play an etiological role in ASD development. In addition, we discuss the future possibilities of MAR ASD treatment. Dove 2020-06-03 /pmc/articles/PMC7276202/ /pubmed/32581542 http://dx.doi.org/10.2147/NDT.S239504 Text en © 2020 Dudova et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Review
Dudova, Iva
Horackova, Klara
Hrdlicka, Michal
Balastik, Martin
Can Maternal Autoantibodies Play an Etiological Role in ASD Development?
title Can Maternal Autoantibodies Play an Etiological Role in ASD Development?
title_full Can Maternal Autoantibodies Play an Etiological Role in ASD Development?
title_fullStr Can Maternal Autoantibodies Play an Etiological Role in ASD Development?
title_full_unstemmed Can Maternal Autoantibodies Play an Etiological Role in ASD Development?
title_short Can Maternal Autoantibodies Play an Etiological Role in ASD Development?
title_sort can maternal autoantibodies play an etiological role in asd development?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7276202/
https://www.ncbi.nlm.nih.gov/pubmed/32581542
http://dx.doi.org/10.2147/NDT.S239504
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