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Can Maternal Autoantibodies Play an Etiological Role in ASD Development?
Autism spectrum disorder (ASD) is a heterogeneous condition with multiple etiologies and risk factors – both genetic and environmental. Recent data demonstrate that the immune system plays an important role in prenatal brain development. Deregulation of the immune system during embryonic development...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7276202/ https://www.ncbi.nlm.nih.gov/pubmed/32581542 http://dx.doi.org/10.2147/NDT.S239504 |
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author | Dudova, Iva Horackova, Klara Hrdlicka, Michal Balastik, Martin |
author_facet | Dudova, Iva Horackova, Klara Hrdlicka, Michal Balastik, Martin |
author_sort | Dudova, Iva |
collection | PubMed |
description | Autism spectrum disorder (ASD) is a heterogeneous condition with multiple etiologies and risk factors – both genetic and environmental. Recent data demonstrate that the immune system plays an important role in prenatal brain development. Deregulation of the immune system during embryonic development can lead to neurodevelopmental changes resulting in ASD. One of the potential etiologic factors in the development of ASD has been identified as the presence of maternal autoantibodies targeting fetal brain proteins. The type of ASD associated with the presence of maternal autoantibodies has been referred to as maternal antibodies related to ASD (MAR ASD). The link between maternal autoantibodies and ASD has been demonstrated in both clinical studies and animal models, but the exact mechanism of their action in the pathogenesis of ASD has not been clarified yet. Several protein targets of ASD-related maternal autoantibodies have been identified. Here, we discuss the role of microtubule-associated proteins of the collapsin response mediator protein (CRMP) family in neurodevelopment and ASD. CRMPs have been shown to integrate multiple signaling cascades regulating neuron growth, guidance or migration. Their targeting by maternal autoantibodies could change CRMP levels or distribution in the developing nervous system, leading to defects in axon growth/guidance, cortical migration, or dendritic projection, which could play an etiological role in ASD development. In addition, we discuss the future possibilities of MAR ASD treatment. |
format | Online Article Text |
id | pubmed-7276202 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Dove |
record_format | MEDLINE/PubMed |
spelling | pubmed-72762022020-06-23 Can Maternal Autoantibodies Play an Etiological Role in ASD Development? Dudova, Iva Horackova, Klara Hrdlicka, Michal Balastik, Martin Neuropsychiatr Dis Treat Review Autism spectrum disorder (ASD) is a heterogeneous condition with multiple etiologies and risk factors – both genetic and environmental. Recent data demonstrate that the immune system plays an important role in prenatal brain development. Deregulation of the immune system during embryonic development can lead to neurodevelopmental changes resulting in ASD. One of the potential etiologic factors in the development of ASD has been identified as the presence of maternal autoantibodies targeting fetal brain proteins. The type of ASD associated with the presence of maternal autoantibodies has been referred to as maternal antibodies related to ASD (MAR ASD). The link between maternal autoantibodies and ASD has been demonstrated in both clinical studies and animal models, but the exact mechanism of their action in the pathogenesis of ASD has not been clarified yet. Several protein targets of ASD-related maternal autoantibodies have been identified. Here, we discuss the role of microtubule-associated proteins of the collapsin response mediator protein (CRMP) family in neurodevelopment and ASD. CRMPs have been shown to integrate multiple signaling cascades regulating neuron growth, guidance or migration. Their targeting by maternal autoantibodies could change CRMP levels or distribution in the developing nervous system, leading to defects in axon growth/guidance, cortical migration, or dendritic projection, which could play an etiological role in ASD development. In addition, we discuss the future possibilities of MAR ASD treatment. Dove 2020-06-03 /pmc/articles/PMC7276202/ /pubmed/32581542 http://dx.doi.org/10.2147/NDT.S239504 Text en © 2020 Dudova et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
spellingShingle | Review Dudova, Iva Horackova, Klara Hrdlicka, Michal Balastik, Martin Can Maternal Autoantibodies Play an Etiological Role in ASD Development? |
title | Can Maternal Autoantibodies Play an Etiological Role in ASD Development? |
title_full | Can Maternal Autoantibodies Play an Etiological Role in ASD Development? |
title_fullStr | Can Maternal Autoantibodies Play an Etiological Role in ASD Development? |
title_full_unstemmed | Can Maternal Autoantibodies Play an Etiological Role in ASD Development? |
title_short | Can Maternal Autoantibodies Play an Etiological Role in ASD Development? |
title_sort | can maternal autoantibodies play an etiological role in asd development? |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7276202/ https://www.ncbi.nlm.nih.gov/pubmed/32581542 http://dx.doi.org/10.2147/NDT.S239504 |
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