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Association between serum uric acid level and endothelial dysfunction in elderly individuals with untreated mild hypertension

BACKGROUND: Endothelial dysfunction is the initial stage in atherosclerotic formation and progression and is associated with high serum uric acid (SUA) level. We hypothesized that reactive hyperemia index (RHI), which reflects endothelial function, is associated with SUA levels in elderly individual...

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Autores principales: Zhu, Guo-Hua, Sun, Xi-Peng, Li, Jing, Liu, Rong-Kun, Yang, Zheng, Hua, Qi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Science Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7276314/
https://www.ncbi.nlm.nih.gov/pubmed/32547609
http://dx.doi.org/10.11909/j.issn.1671-5411.2020.05.005
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author Zhu, Guo-Hua
Sun, Xi-Peng
Li, Jing
Liu, Rong-Kun
Yang, Zheng
Hua, Qi
author_facet Zhu, Guo-Hua
Sun, Xi-Peng
Li, Jing
Liu, Rong-Kun
Yang, Zheng
Hua, Qi
author_sort Zhu, Guo-Hua
collection PubMed
description BACKGROUND: Endothelial dysfunction is the initial stage in atherosclerotic formation and progression and is associated with high serum uric acid (SUA) level. We hypothesized that reactive hyperemia index (RHI), which reflects endothelial function, is associated with SUA levels in elderly individuals with untreated mild hypertension. METHODS: We recruited 123 patients ≥ 60 years with untreated mild hypertension. The association between SUA level and RHI was analyzed using univariate correlation analysis and multiple regression analysis. The receiver operating characteristic (ROC) curve was performed to validate the cutoff value of SUA that can be used to predict endothelial dysfunction. RESULTS: The serum uric acid level significantly increased in the RHI < 1.67 group, and this result was still observed in the subgroup of men. RHI was inversely associated with SUA level (P = 0.006) and the association was still observed after adjusting for factors, such as age, sex, smoking status, and creatinine level (P = 0.014). In the subgroup analysis, a positive association was observed only in men. In the ROC curve analysis, the optimal cutoff values of SUA for predicting endothelial dysfunction was 293.5 µmol/L in elderly mild hypertension patients and 287.0 µmol/L in men. CONCLUSION: A high SUA level was considered an independent predictor of endothelial dysfunction among elderly individuals, particularly men with untreated mild hypertension.
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spelling pubmed-72763142020-06-15 Association between serum uric acid level and endothelial dysfunction in elderly individuals with untreated mild hypertension Zhu, Guo-Hua Sun, Xi-Peng Li, Jing Liu, Rong-Kun Yang, Zheng Hua, Qi J Geriatr Cardiol Research Article BACKGROUND: Endothelial dysfunction is the initial stage in atherosclerotic formation and progression and is associated with high serum uric acid (SUA) level. We hypothesized that reactive hyperemia index (RHI), which reflects endothelial function, is associated with SUA levels in elderly individuals with untreated mild hypertension. METHODS: We recruited 123 patients ≥ 60 years with untreated mild hypertension. The association between SUA level and RHI was analyzed using univariate correlation analysis and multiple regression analysis. The receiver operating characteristic (ROC) curve was performed to validate the cutoff value of SUA that can be used to predict endothelial dysfunction. RESULTS: The serum uric acid level significantly increased in the RHI < 1.67 group, and this result was still observed in the subgroup of men. RHI was inversely associated with SUA level (P = 0.006) and the association was still observed after adjusting for factors, such as age, sex, smoking status, and creatinine level (P = 0.014). In the subgroup analysis, a positive association was observed only in men. In the ROC curve analysis, the optimal cutoff values of SUA for predicting endothelial dysfunction was 293.5 µmol/L in elderly mild hypertension patients and 287.0 µmol/L in men. CONCLUSION: A high SUA level was considered an independent predictor of endothelial dysfunction among elderly individuals, particularly men with untreated mild hypertension. Science Press 2020-05 /pmc/articles/PMC7276314/ /pubmed/32547609 http://dx.doi.org/10.11909/j.issn.1671-5411.2020.05.005 Text en Institute of Geriatric Cardiology http://creativecommons.org/licenses/by-nc-sa/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License, which allows readers to alter, transform, or build upon the article and then distribute the resulting work under the same or similar license to this one. The work must be attributed back to the original author and commercial use is not permitted without specific permission.
spellingShingle Research Article
Zhu, Guo-Hua
Sun, Xi-Peng
Li, Jing
Liu, Rong-Kun
Yang, Zheng
Hua, Qi
Association between serum uric acid level and endothelial dysfunction in elderly individuals with untreated mild hypertension
title Association between serum uric acid level and endothelial dysfunction in elderly individuals with untreated mild hypertension
title_full Association between serum uric acid level and endothelial dysfunction in elderly individuals with untreated mild hypertension
title_fullStr Association between serum uric acid level and endothelial dysfunction in elderly individuals with untreated mild hypertension
title_full_unstemmed Association between serum uric acid level and endothelial dysfunction in elderly individuals with untreated mild hypertension
title_short Association between serum uric acid level and endothelial dysfunction in elderly individuals with untreated mild hypertension
title_sort association between serum uric acid level and endothelial dysfunction in elderly individuals with untreated mild hypertension
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7276314/
https://www.ncbi.nlm.nih.gov/pubmed/32547609
http://dx.doi.org/10.11909/j.issn.1671-5411.2020.05.005
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