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Shelterin Complex at Telomeres: Implications in Ageing
Different factors influence the development and control of ageing. It is well known that progressive telomere shorting is one of the molecular mechanisms underlying ageing. The shelterin complex consists of six telomere-specific proteins which are involved in the protection of chromosome ends. More...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7276337/ https://www.ncbi.nlm.nih.gov/pubmed/32581523 http://dx.doi.org/10.2147/CIA.S256425 |
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author | Mir, Seyed Mostafa Samavarchi Tehrani, Sadra Goodarzi, Golnaz Jamalpoor, Zahra Asadi, Jahanbakhsh Khelghati, Nafiseh Qujeq, Durdi Maniati, Mahmood |
author_facet | Mir, Seyed Mostafa Samavarchi Tehrani, Sadra Goodarzi, Golnaz Jamalpoor, Zahra Asadi, Jahanbakhsh Khelghati, Nafiseh Qujeq, Durdi Maniati, Mahmood |
author_sort | Mir, Seyed Mostafa |
collection | PubMed |
description | Different factors influence the development and control of ageing. It is well known that progressive telomere shorting is one of the molecular mechanisms underlying ageing. The shelterin complex consists of six telomere-specific proteins which are involved in the protection of chromosome ends. More particularly, this vital complex protects the telomeres from degradation, prevents from activation of unwanted repair systems, regulates the activity of telomerase, and has a crucial role in cellular senescent and ageing-related pathologies. This review explores the organization and function of telomeric DNA along with the mechanism of telomeres during ageing, followed by a discussion of the critical role of shelterin components and their changes during ageing. |
format | Online Article Text |
id | pubmed-7276337 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Dove |
record_format | MEDLINE/PubMed |
spelling | pubmed-72763372020-06-23 Shelterin Complex at Telomeres: Implications in Ageing Mir, Seyed Mostafa Samavarchi Tehrani, Sadra Goodarzi, Golnaz Jamalpoor, Zahra Asadi, Jahanbakhsh Khelghati, Nafiseh Qujeq, Durdi Maniati, Mahmood Clin Interv Aging Review Different factors influence the development and control of ageing. It is well known that progressive telomere shorting is one of the molecular mechanisms underlying ageing. The shelterin complex consists of six telomere-specific proteins which are involved in the protection of chromosome ends. More particularly, this vital complex protects the telomeres from degradation, prevents from activation of unwanted repair systems, regulates the activity of telomerase, and has a crucial role in cellular senescent and ageing-related pathologies. This review explores the organization and function of telomeric DNA along with the mechanism of telomeres during ageing, followed by a discussion of the critical role of shelterin components and their changes during ageing. Dove 2020-06-03 /pmc/articles/PMC7276337/ /pubmed/32581523 http://dx.doi.org/10.2147/CIA.S256425 Text en © 2020 Mir et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
spellingShingle | Review Mir, Seyed Mostafa Samavarchi Tehrani, Sadra Goodarzi, Golnaz Jamalpoor, Zahra Asadi, Jahanbakhsh Khelghati, Nafiseh Qujeq, Durdi Maniati, Mahmood Shelterin Complex at Telomeres: Implications in Ageing |
title | Shelterin Complex at Telomeres: Implications in Ageing |
title_full | Shelterin Complex at Telomeres: Implications in Ageing |
title_fullStr | Shelterin Complex at Telomeres: Implications in Ageing |
title_full_unstemmed | Shelterin Complex at Telomeres: Implications in Ageing |
title_short | Shelterin Complex at Telomeres: Implications in Ageing |
title_sort | shelterin complex at telomeres: implications in ageing |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7276337/ https://www.ncbi.nlm.nih.gov/pubmed/32581523 http://dx.doi.org/10.2147/CIA.S256425 |
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