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Highlights of marine natural products having parallel scaffolds found from marine-derived bacteria, sponges, and tunicates

Marine-derived bacteria are a prolific source of a wide range of structurally diverse natural products. This review, dedicated to Professor William Fenical, begins by showcasing many seminal discoveries made at the University of California San Diego from marine-derived actinomycetes. Discussed early...

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Autores principales: McCauley, Erin P., Piña, Ivett C., Thompson, Alyssa D., Bashir, Kashif, Weinberg, Miriam, Kurz, Shannon L., Crews, Phillip
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7276339/
https://www.ncbi.nlm.nih.gov/pubmed/32507851
http://dx.doi.org/10.1038/s41429-020-0330-5
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author McCauley, Erin P.
Piña, Ivett C.
Thompson, Alyssa D.
Bashir, Kashif
Weinberg, Miriam
Kurz, Shannon L.
Crews, Phillip
author_facet McCauley, Erin P.
Piña, Ivett C.
Thompson, Alyssa D.
Bashir, Kashif
Weinberg, Miriam
Kurz, Shannon L.
Crews, Phillip
author_sort McCauley, Erin P.
collection PubMed
description Marine-derived bacteria are a prolific source of a wide range of structurally diverse natural products. This review, dedicated to Professor William Fenical, begins by showcasing many seminal discoveries made at the University of California San Diego from marine-derived actinomycetes. Discussed early on is the 20-year journey of discovery and advancement of the seminal actinomycetes natural product salinosporamide A into Phase III anticancer clinical trials. There are many fascinating parallels discussed that were gleaned from the comparative literature of marine sponge, tunicate, and bacteria-derived natural products. Identifying bacterial biosynthetic machinery housed in sponge and tunicate holobionts through both culture-independent and culture-dependent approaches is another important and expanding subject that is analyzed. Work reviewed herein also evaluates the hypotheses that many marine invertebrate-derived natural products are biosynthesised by associated or symbiotic bacteria. The insights and outcomes from metagenomic sequencing and synthetic biology to expand molecule discovery continue to provide exciting outcomes and they are predicted to be the source of the next generation of novel marine natural product chemical scaffolds.
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spelling pubmed-72763392020-06-08 Highlights of marine natural products having parallel scaffolds found from marine-derived bacteria, sponges, and tunicates McCauley, Erin P. Piña, Ivett C. Thompson, Alyssa D. Bashir, Kashif Weinberg, Miriam Kurz, Shannon L. Crews, Phillip J Antibiot (Tokyo) Special Feature: Review Article Marine-derived bacteria are a prolific source of a wide range of structurally diverse natural products. This review, dedicated to Professor William Fenical, begins by showcasing many seminal discoveries made at the University of California San Diego from marine-derived actinomycetes. Discussed early on is the 20-year journey of discovery and advancement of the seminal actinomycetes natural product salinosporamide A into Phase III anticancer clinical trials. There are many fascinating parallels discussed that were gleaned from the comparative literature of marine sponge, tunicate, and bacteria-derived natural products. Identifying bacterial biosynthetic machinery housed in sponge and tunicate holobionts through both culture-independent and culture-dependent approaches is another important and expanding subject that is analyzed. Work reviewed herein also evaluates the hypotheses that many marine invertebrate-derived natural products are biosynthesised by associated or symbiotic bacteria. The insights and outcomes from metagenomic sequencing and synthetic biology to expand molecule discovery continue to provide exciting outcomes and they are predicted to be the source of the next generation of novel marine natural product chemical scaffolds. Nature Publishing Group UK 2020-06-08 2020 /pmc/articles/PMC7276339/ /pubmed/32507851 http://dx.doi.org/10.1038/s41429-020-0330-5 Text en © The Author(s), under exclusive licence to the Japan Antibiotics Research Association 2020 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Special Feature: Review Article
McCauley, Erin P.
Piña, Ivett C.
Thompson, Alyssa D.
Bashir, Kashif
Weinberg, Miriam
Kurz, Shannon L.
Crews, Phillip
Highlights of marine natural products having parallel scaffolds found from marine-derived bacteria, sponges, and tunicates
title Highlights of marine natural products having parallel scaffolds found from marine-derived bacteria, sponges, and tunicates
title_full Highlights of marine natural products having parallel scaffolds found from marine-derived bacteria, sponges, and tunicates
title_fullStr Highlights of marine natural products having parallel scaffolds found from marine-derived bacteria, sponges, and tunicates
title_full_unstemmed Highlights of marine natural products having parallel scaffolds found from marine-derived bacteria, sponges, and tunicates
title_short Highlights of marine natural products having parallel scaffolds found from marine-derived bacteria, sponges, and tunicates
title_sort highlights of marine natural products having parallel scaffolds found from marine-derived bacteria, sponges, and tunicates
topic Special Feature: Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7276339/
https://www.ncbi.nlm.nih.gov/pubmed/32507851
http://dx.doi.org/10.1038/s41429-020-0330-5
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