Oncolytic Activity of Targeted Picornaviruses Formulated as Synthetic Infectious RNA

Infectious nucleic acid has been proposed as a superior formulation for oncolytic virus therapy. Oncolytic picornaviruses can be formulated as infectious RNA (iRNA), and their unwanted tropisms eliminated by microRNA (miRNA) detargeting. However, genomic insertion of miRNA target sequences into coxs...

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Detalles Bibliográficos
Autores principales: Elsedawy, Noura B., Nace, Rebecca A., Russell, Stephen J., Schulze, Autumn J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7276391/
https://www.ncbi.nlm.nih.gov/pubmed/32529026
http://dx.doi.org/10.1016/j.omto.2020.05.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7276391/
https://www.ncbi.nlm.nih.gov/pubmed/32529026
http://dx.doi.org/10.1016/j.omto.2020.05.003

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