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Crosstalk between the microbiota-gut-brain axis and depression

Nutritional and microbiological psychiatry, especially the contribution of the gut microbiota to depression, has become a promising research field over the past several decades. An imbalance in the “microbiota-gut-brain axis”, which reflects the constant bidirectional communication between the centr...

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Detalles Bibliográficos
Autores principales: Du, Yu, Gao, Xin-Ran, Peng, Lei, Ge, Jin-Fang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7276434/
https://www.ncbi.nlm.nih.gov/pubmed/32529075
http://dx.doi.org/10.1016/j.heliyon.2020.e04097
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author Du, Yu
Gao, Xin-Ran
Peng, Lei
Ge, Jin-Fang
author_facet Du, Yu
Gao, Xin-Ran
Peng, Lei
Ge, Jin-Fang
author_sort Du, Yu
collection PubMed
description Nutritional and microbiological psychiatry, especially the contribution of the gut microbiota to depression, has become a promising research field over the past several decades. An imbalance in the “microbiota-gut-brain axis”, which reflects the constant bidirectional communication between the central nervous system and the gastrointestinal tract, has been used as a hypothesis to interpret the pathogenesis of depression. Alterations in gut microbiota composition could increase the permeability of the gut barrier, activate systemic inflammation and immune responses, regulate the release and efficacy of monoamine neurotransmitters, alter the activity and function of the hypothalamic-pituitary-adrenal (HPA) axis, and modify the abundance of brain-derived neurotrophic factor (BDNF), eventually leading to depression. In this article, we review changes in gut microbiota in depressive states, the association between these changes and depression-like behavior, the potential mechanism linking gut microbiota disruptions and depression, and preliminary attempts at using gut microbiota intervention for the treatment of depression. In summary, although the link between gut microbiota and depression and the potential mechanism have been discussed, a more detailed mechanistic understanding is needed to fully realize the importance of the microbiota-gut-brain axis in depression. Future efforts should aim to determine the potential causative mechanisms, which will require further animal and clinical research as well as the development of analytical approaches.
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spelling pubmed-72764342020-06-10 Crosstalk between the microbiota-gut-brain axis and depression Du, Yu Gao, Xin-Ran Peng, Lei Ge, Jin-Fang Heliyon Article Nutritional and microbiological psychiatry, especially the contribution of the gut microbiota to depression, has become a promising research field over the past several decades. An imbalance in the “microbiota-gut-brain axis”, which reflects the constant bidirectional communication between the central nervous system and the gastrointestinal tract, has been used as a hypothesis to interpret the pathogenesis of depression. Alterations in gut microbiota composition could increase the permeability of the gut barrier, activate systemic inflammation and immune responses, regulate the release and efficacy of monoamine neurotransmitters, alter the activity and function of the hypothalamic-pituitary-adrenal (HPA) axis, and modify the abundance of brain-derived neurotrophic factor (BDNF), eventually leading to depression. In this article, we review changes in gut microbiota in depressive states, the association between these changes and depression-like behavior, the potential mechanism linking gut microbiota disruptions and depression, and preliminary attempts at using gut microbiota intervention for the treatment of depression. In summary, although the link between gut microbiota and depression and the potential mechanism have been discussed, a more detailed mechanistic understanding is needed to fully realize the importance of the microbiota-gut-brain axis in depression. Future efforts should aim to determine the potential causative mechanisms, which will require further animal and clinical research as well as the development of analytical approaches. Elsevier 2020-06-03 /pmc/articles/PMC7276434/ /pubmed/32529075 http://dx.doi.org/10.1016/j.heliyon.2020.e04097 Text en © 2020 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Du, Yu
Gao, Xin-Ran
Peng, Lei
Ge, Jin-Fang
Crosstalk between the microbiota-gut-brain axis and depression
title Crosstalk between the microbiota-gut-brain axis and depression
title_full Crosstalk between the microbiota-gut-brain axis and depression
title_fullStr Crosstalk between the microbiota-gut-brain axis and depression
title_full_unstemmed Crosstalk between the microbiota-gut-brain axis and depression
title_short Crosstalk between the microbiota-gut-brain axis and depression
title_sort crosstalk between the microbiota-gut-brain axis and depression
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7276434/
https://www.ncbi.nlm.nih.gov/pubmed/32529075
http://dx.doi.org/10.1016/j.heliyon.2020.e04097
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