Pazopanib-induced organizing pneumonia in a patient with leiomyosarcoma: A case report

Pazopanib, a multityrosine kinase inhibitor used for treating malignant soft tissue tumors, rarely causes adverse events associated with the respiratory system. We report a case of a 73-year-old male with leiomyosarcoma treated with pazopanib. Four months after treatment initiation, chest computed t...

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Autores principales: Watanabe, Chie, Miyata, Jun, Esaki, Kotoba, Suematsu, Ryohei, Sano, Tomoya, Yamamoto, Takayuki, Sasaki, Hisashi, Maki, Yohei, Tagami, Yoichi, Kimizuka, Yoshifumi, Fujikura, Yuji, Ito, Keiichi, Kawana, Akihiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7276494/
https://www.ncbi.nlm.nih.gov/pubmed/32528844
http://dx.doi.org/10.1016/j.rmcr.2020.101112
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author Watanabe, Chie
Miyata, Jun
Esaki, Kotoba
Suematsu, Ryohei
Sano, Tomoya
Yamamoto, Takayuki
Sasaki, Hisashi
Maki, Yohei
Tagami, Yoichi
Kimizuka, Yoshifumi
Fujikura, Yuji
Ito, Keiichi
Kawana, Akihiko
author_facet Watanabe, Chie
Miyata, Jun
Esaki, Kotoba
Suematsu, Ryohei
Sano, Tomoya
Yamamoto, Takayuki
Sasaki, Hisashi
Maki, Yohei
Tagami, Yoichi
Kimizuka, Yoshifumi
Fujikura, Yuji
Ito, Keiichi
Kawana, Akihiko
author_sort Watanabe, Chie
collection PubMed
description Pazopanib, a multityrosine kinase inhibitor used for treating malignant soft tissue tumors, rarely causes adverse events associated with the respiratory system. We report a case of a 73-year-old male with leiomyosarcoma treated with pazopanib. Four months after treatment initiation, chest computed tomography showed bilateral patchy consolidation and ground-glass opacities. Bronchoscopy revealed increased lymphocytes in the bronchoalveolar lavage fluid. Histological analysis of lung tissue demonstrated intraluminal fibrotic changes in alveolar spaces. According to these findings, we diagnosed the patient with pazopanib-induced organizing pneumonia. To best of our knowledge, this is the first report of such a case.
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spelling pubmed-72764942020-06-10 Pazopanib-induced organizing pneumonia in a patient with leiomyosarcoma: A case report Watanabe, Chie Miyata, Jun Esaki, Kotoba Suematsu, Ryohei Sano, Tomoya Yamamoto, Takayuki Sasaki, Hisashi Maki, Yohei Tagami, Yoichi Kimizuka, Yoshifumi Fujikura, Yuji Ito, Keiichi Kawana, Akihiko Respir Med Case Rep Case Report Pazopanib, a multityrosine kinase inhibitor used for treating malignant soft tissue tumors, rarely causes adverse events associated with the respiratory system. We report a case of a 73-year-old male with leiomyosarcoma treated with pazopanib. Four months after treatment initiation, chest computed tomography showed bilateral patchy consolidation and ground-glass opacities. Bronchoscopy revealed increased lymphocytes in the bronchoalveolar lavage fluid. Histological analysis of lung tissue demonstrated intraluminal fibrotic changes in alveolar spaces. According to these findings, we diagnosed the patient with pazopanib-induced organizing pneumonia. To best of our knowledge, this is the first report of such a case. Elsevier 2020-05-31 /pmc/articles/PMC7276494/ /pubmed/32528844 http://dx.doi.org/10.1016/j.rmcr.2020.101112 Text en © 2020 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Watanabe, Chie
Miyata, Jun
Esaki, Kotoba
Suematsu, Ryohei
Sano, Tomoya
Yamamoto, Takayuki
Sasaki, Hisashi
Maki, Yohei
Tagami, Yoichi
Kimizuka, Yoshifumi
Fujikura, Yuji
Ito, Keiichi
Kawana, Akihiko
Pazopanib-induced organizing pneumonia in a patient with leiomyosarcoma: A case report
title Pazopanib-induced organizing pneumonia in a patient with leiomyosarcoma: A case report
title_full Pazopanib-induced organizing pneumonia in a patient with leiomyosarcoma: A case report
title_fullStr Pazopanib-induced organizing pneumonia in a patient with leiomyosarcoma: A case report
title_full_unstemmed Pazopanib-induced organizing pneumonia in a patient with leiomyosarcoma: A case report
title_short Pazopanib-induced organizing pneumonia in a patient with leiomyosarcoma: A case report
title_sort pazopanib-induced organizing pneumonia in a patient with leiomyosarcoma: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7276494/
https://www.ncbi.nlm.nih.gov/pubmed/32528844
http://dx.doi.org/10.1016/j.rmcr.2020.101112
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