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Topoisomerase IIα prevents ultrafine anaphase bridges by two mechanisms

Topoisomerase IIα (Topo IIα), a well-conserved double-stranded DNA (dsDNA)-specific decatenase, processes dsDNA catenanes resulting from DNA replication during mitosis. Topo IIα defects lead to an accumulation of ultrafine anaphase bridges (UFBs), a type of chromosome non-disjunction. Topo IIα has b...

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Detalles Bibliográficos
Autores principales:	Gemble, Simon, Buhagiar-Labarchède, Géraldine, Onclercq-Delic, Rosine, Fontaine, Gaëlle, Lambert, Sarah, Amor-Guéret, Mounira
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society 2020
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7276528/ https://www.ncbi.nlm.nih.gov/pubmed/32400307 http://dx.doi.org/10.1098/rsob.190259

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