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Understanding the mammalian TRAP complex function(s)
In eukaryotic cells, about one-third of the synthesized proteins are translocated into the endoplasmic reticulum; they are membrane or lumen resident proteins and proteins direct to the Golgi apparatus. The co-translational translocation takes place through the heterotrimeric protein-conducting chan...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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The Royal Society
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7276530/ https://www.ncbi.nlm.nih.gov/pubmed/32453970 http://dx.doi.org/10.1098/rsob.190244 |
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author | Russo, Antonietta |
author_facet | Russo, Antonietta |
author_sort | Russo, Antonietta |
collection | PubMed |
description | In eukaryotic cells, about one-third of the synthesized proteins are translocated into the endoplasmic reticulum; they are membrane or lumen resident proteins and proteins direct to the Golgi apparatus. The co-translational translocation takes place through the heterotrimeric protein-conducting channel Sec61 which is associated with the ribosome and many accessory components, such as the heterotetrameric translocon-associated protein (TRAP) complex. Recently, microscopic techniques, such as cryo-electron microscopy and cryo-electron tomography, have enabled the determination of the translocation machinery structure. However, at present, there is a lack of understanding regarding the roles of some of its components; indeed, the TRAP complex function during co-translational translocation needs to be established. In addition, TRAP may play a role during unfolded protein response, endoplasmic-reticulum-associated protein degradation and congenital disorder of glycosylation (ssr4 CDG). In this article, I describe the current understanding of the TRAP complex in the light of its possible function(s). |
format | Online Article Text |
id | pubmed-7276530 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | The Royal Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-72765302020-06-08 Understanding the mammalian TRAP complex function(s) Russo, Antonietta Open Biol Review In eukaryotic cells, about one-third of the synthesized proteins are translocated into the endoplasmic reticulum; they are membrane or lumen resident proteins and proteins direct to the Golgi apparatus. The co-translational translocation takes place through the heterotrimeric protein-conducting channel Sec61 which is associated with the ribosome and many accessory components, such as the heterotetrameric translocon-associated protein (TRAP) complex. Recently, microscopic techniques, such as cryo-electron microscopy and cryo-electron tomography, have enabled the determination of the translocation machinery structure. However, at present, there is a lack of understanding regarding the roles of some of its components; indeed, the TRAP complex function during co-translational translocation needs to be established. In addition, TRAP may play a role during unfolded protein response, endoplasmic-reticulum-associated protein degradation and congenital disorder of glycosylation (ssr4 CDG). In this article, I describe the current understanding of the TRAP complex in the light of its possible function(s). The Royal Society 2020-05-27 /pmc/articles/PMC7276530/ /pubmed/32453970 http://dx.doi.org/10.1098/rsob.190244 Text en © 2020 The Authors. http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/http://creativecommons.org/licenses/by/4.0/Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited. |
spellingShingle | Review Russo, Antonietta Understanding the mammalian TRAP complex function(s) |
title | Understanding the mammalian TRAP complex function(s) |
title_full | Understanding the mammalian TRAP complex function(s) |
title_fullStr | Understanding the mammalian TRAP complex function(s) |
title_full_unstemmed | Understanding the mammalian TRAP complex function(s) |
title_short | Understanding the mammalian TRAP complex function(s) |
title_sort | understanding the mammalian trap complex function(s) |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7276530/ https://www.ncbi.nlm.nih.gov/pubmed/32453970 http://dx.doi.org/10.1098/rsob.190244 |
work_keys_str_mv | AT russoantonietta understandingthemammaliantrapcomplexfunctions |