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Bone Crushing in Infected Pseudarthrosis – An Extraordinary Way to Treat Osteomyelitis Caused by Resistant Bacteria

INTRODUCTION: Osteomyelitis with multiresistant bacteria in non-union following fracture treated with osteosynthesis requires complete removal of infected sequestrum and dead bone. For consecutive bone defects, it is frequently necessary to bridge with a fixator external. The treatment is not only c...

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Autores principales: Reichelt, Martin, Gehmert, Sebastian, Krieg, Andreas, Nowakowski, Andrej M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Indian Orthopaedic Research Group 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7276597/
https://www.ncbi.nlm.nih.gov/pubmed/32548034
http://dx.doi.org/10.13107/jocr.2019.v09.i06.1596
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author Reichelt, Martin
Gehmert, Sebastian
Krieg, Andreas
Nowakowski, Andrej M
author_facet Reichelt, Martin
Gehmert, Sebastian
Krieg, Andreas
Nowakowski, Andrej M
author_sort Reichelt, Martin
collection PubMed
description INTRODUCTION: Osteomyelitis with multiresistant bacteria in non-union following fracture treated with osteosynthesis requires complete removal of infected sequestrum and dead bone. For consecutive bone defects, it is frequently necessary to bridge with a fixator external. The treatment is not only challenging due to reduced bone stock but also characterized by decreased bioavailability of antibiotics. CASE REPORT: We report a two-step-surgery approach to preserve the bone stock using autologous cancellous bone in a bacterial infected non-union for subsequently leg length reconstruction. The 24-year-old male patient from Belarus was admitted to our department with persistent wound secretion and subsequent osteomyelitis of the right femur 3 years after initial surgery, several revisions, and several different antibiotic therapies. Biopsy revealed methicillin-resistant and borderline oxacillin-resistant Staphylococcus aureus. Firstly, the Ilizarov ring fixator was removed and a vigorous debridement was performed by refreshing the pseudarthrosis, removing of sequestrum, and dead bone. Finally, an AO fixator external was applied for 10 weeks combined with appropriate antibiotic treatment followed by 5 weeks antibiotic-free window. The bone defect was stabilized by a long gamma trochanteric nail after removal of the AO fixateurexterne. A wide resection of the fragments was performed and the resected bone tissue was crushed and placed adjacent to the nail. Noteworthy, the biopsies of both re-section sides revealed same germs as detected in initial biopsies. Thus, antibiotics were administered for additional 3 months. Frequent radiographic and clinical controls showed a remodeling of the femur during a period of 3 years and no signs of infection. Subsequently, we restored leg length of 4 cm using a fully implantable motorized lengthening nail. In the end, the patient achieved full weight-bearing with unlimited range of motion in hip and knee. No further germ could be revealed in biopsies. CONCLUSION: In this case report, we used autologous bone from the infected side, crushed, and placed it adjacent to an intramedullary nail. Crushed bone tissue might improve bioavailability of antibiotics when dealing with multiresistant bacteria in non-union healed fracture side. Furthermore, this approach was able to provide new bone formation in a limb resulting in full weight-bearing.
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spelling pubmed-72765972020-06-15 Bone Crushing in Infected Pseudarthrosis – An Extraordinary Way to Treat Osteomyelitis Caused by Resistant Bacteria Reichelt, Martin Gehmert, Sebastian Krieg, Andreas Nowakowski, Andrej M J Orthop Case Rep Case Report INTRODUCTION: Osteomyelitis with multiresistant bacteria in non-union following fracture treated with osteosynthesis requires complete removal of infected sequestrum and dead bone. For consecutive bone defects, it is frequently necessary to bridge with a fixator external. The treatment is not only challenging due to reduced bone stock but also characterized by decreased bioavailability of antibiotics. CASE REPORT: We report a two-step-surgery approach to preserve the bone stock using autologous cancellous bone in a bacterial infected non-union for subsequently leg length reconstruction. The 24-year-old male patient from Belarus was admitted to our department with persistent wound secretion and subsequent osteomyelitis of the right femur 3 years after initial surgery, several revisions, and several different antibiotic therapies. Biopsy revealed methicillin-resistant and borderline oxacillin-resistant Staphylococcus aureus. Firstly, the Ilizarov ring fixator was removed and a vigorous debridement was performed by refreshing the pseudarthrosis, removing of sequestrum, and dead bone. Finally, an AO fixator external was applied for 10 weeks combined with appropriate antibiotic treatment followed by 5 weeks antibiotic-free window. The bone defect was stabilized by a long gamma trochanteric nail after removal of the AO fixateurexterne. A wide resection of the fragments was performed and the resected bone tissue was crushed and placed adjacent to the nail. Noteworthy, the biopsies of both re-section sides revealed same germs as detected in initial biopsies. Thus, antibiotics were administered for additional 3 months. Frequent radiographic and clinical controls showed a remodeling of the femur during a period of 3 years and no signs of infection. Subsequently, we restored leg length of 4 cm using a fully implantable motorized lengthening nail. In the end, the patient achieved full weight-bearing with unlimited range of motion in hip and knee. No further germ could be revealed in biopsies. CONCLUSION: In this case report, we used autologous bone from the infected side, crushed, and placed it adjacent to an intramedullary nail. Crushed bone tissue might improve bioavailability of antibiotics when dealing with multiresistant bacteria in non-union healed fracture side. Furthermore, this approach was able to provide new bone formation in a limb resulting in full weight-bearing. Indian Orthopaedic Research Group 2020 /pmc/articles/PMC7276597/ /pubmed/32548034 http://dx.doi.org/10.13107/jocr.2019.v09.i06.1596 Text en Copyright: © Indian Orthopaedic Research Group http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Reichelt, Martin
Gehmert, Sebastian
Krieg, Andreas
Nowakowski, Andrej M
Bone Crushing in Infected Pseudarthrosis – An Extraordinary Way to Treat Osteomyelitis Caused by Resistant Bacteria
title Bone Crushing in Infected Pseudarthrosis – An Extraordinary Way to Treat Osteomyelitis Caused by Resistant Bacteria
title_full Bone Crushing in Infected Pseudarthrosis – An Extraordinary Way to Treat Osteomyelitis Caused by Resistant Bacteria
title_fullStr Bone Crushing in Infected Pseudarthrosis – An Extraordinary Way to Treat Osteomyelitis Caused by Resistant Bacteria
title_full_unstemmed Bone Crushing in Infected Pseudarthrosis – An Extraordinary Way to Treat Osteomyelitis Caused by Resistant Bacteria
title_short Bone Crushing in Infected Pseudarthrosis – An Extraordinary Way to Treat Osteomyelitis Caused by Resistant Bacteria
title_sort bone crushing in infected pseudarthrosis – an extraordinary way to treat osteomyelitis caused by resistant bacteria
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7276597/
https://www.ncbi.nlm.nih.gov/pubmed/32548034
http://dx.doi.org/10.13107/jocr.2019.v09.i06.1596
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