Cargando…

Genomic consequences of dietary diversification and parallel evolution due to nectarivory in leaf-nosed bats

BACKGROUND: The New World leaf-nosed bats (Phyllostomids) exhibit a diverse spectrum of feeding habits and innovations in their nutrient acquisition and foraging mechanisms. However, the genomic signatures associated with their distinct diets are unknown. RESULTS: We conducted a genomic comparative...

Descripción completa

Detalles Bibliográficos
Autores principales: Gutiérrez-Guerrero, Yocelyn T, Ibarra-Laclette, Enrique, Martínez del Río, Carlos, Barrera-Redondo, Josué, Rebollar, Eria A, Ortega, Jorge, León-Paniagua, Livia, Urrutia, Araxi, Aguirre-Planter, Erika, Eguiarte, Luis E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7276932/
https://www.ncbi.nlm.nih.gov/pubmed/32510151
http://dx.doi.org/10.1093/gigascience/giaa059
_version_ 1783543019790663680
author Gutiérrez-Guerrero, Yocelyn T
Ibarra-Laclette, Enrique
Martínez del Río, Carlos
Barrera-Redondo, Josué
Rebollar, Eria A
Ortega, Jorge
León-Paniagua, Livia
Urrutia, Araxi
Aguirre-Planter, Erika
Eguiarte, Luis E
author_facet Gutiérrez-Guerrero, Yocelyn T
Ibarra-Laclette, Enrique
Martínez del Río, Carlos
Barrera-Redondo, Josué
Rebollar, Eria A
Ortega, Jorge
León-Paniagua, Livia
Urrutia, Araxi
Aguirre-Planter, Erika
Eguiarte, Luis E
author_sort Gutiérrez-Guerrero, Yocelyn T
collection PubMed
description BACKGROUND: The New World leaf-nosed bats (Phyllostomids) exhibit a diverse spectrum of feeding habits and innovations in their nutrient acquisition and foraging mechanisms. However, the genomic signatures associated with their distinct diets are unknown. RESULTS: We conducted a genomic comparative analysis to study the evolutionary dynamics related to dietary diversification and specialization. We sequenced, assembled, and annotated the genomes of five Phyllostomid species: one insect feeder (Macrotus waterhousii), one fruit feeder (Artibeus jamaicensis), and three nectar feeders from the Glossophaginae subfamily (Leptonycteris yerbabuenae, Leptonycteris nivalis, and Musonycteris harrisoni), also including the previously sequenced vampire Desmodus rotundus. Our phylogenomic analysis based on 22,388 gene families displayed differences in expansion and contraction events across the Phyllostomid lineages. Independently of diet, genes relevant for feeding strategies and food intake experienced multiple expansions and signatures of positive selection. We also found adaptation signatures associated with specialized diets: the vampire exhibited traits associated with a blood diet (i.e., coagulation mechanisms), whereas the nectarivore clade shares a group of positively selected genes involved in sugar, lipid, and iron metabolism. Interestingly, in fruit-nectar–feeding Phyllostomid and Pteropodids bats, we detected positive selection in two genes: AACS and ALKBH7, which are crucial in sugar and fat metabolism. Moreover, in these two proteins we found parallel amino acid substitutions in conserved positions exclusive to the tribe Glossophagini and to Pteropodids. CONCLUSIONS: Our findings illuminate the genomic and molecular shifts associated with the evolution of nectarivory and shed light on how nectar-feeding bats can avoid the adverse effects of diets with high glucose content.
format Online
Article
Text
id pubmed-7276932
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Oxford University Press
record_format MEDLINE/PubMed
spelling pubmed-72769322020-06-12 Genomic consequences of dietary diversification and parallel evolution due to nectarivory in leaf-nosed bats Gutiérrez-Guerrero, Yocelyn T Ibarra-Laclette, Enrique Martínez del Río, Carlos Barrera-Redondo, Josué Rebollar, Eria A Ortega, Jorge León-Paniagua, Livia Urrutia, Araxi Aguirre-Planter, Erika Eguiarte, Luis E Gigascience Research BACKGROUND: The New World leaf-nosed bats (Phyllostomids) exhibit a diverse spectrum of feeding habits and innovations in their nutrient acquisition and foraging mechanisms. However, the genomic signatures associated with their distinct diets are unknown. RESULTS: We conducted a genomic comparative analysis to study the evolutionary dynamics related to dietary diversification and specialization. We sequenced, assembled, and annotated the genomes of five Phyllostomid species: one insect feeder (Macrotus waterhousii), one fruit feeder (Artibeus jamaicensis), and three nectar feeders from the Glossophaginae subfamily (Leptonycteris yerbabuenae, Leptonycteris nivalis, and Musonycteris harrisoni), also including the previously sequenced vampire Desmodus rotundus. Our phylogenomic analysis based on 22,388 gene families displayed differences in expansion and contraction events across the Phyllostomid lineages. Independently of diet, genes relevant for feeding strategies and food intake experienced multiple expansions and signatures of positive selection. We also found adaptation signatures associated with specialized diets: the vampire exhibited traits associated with a blood diet (i.e., coagulation mechanisms), whereas the nectarivore clade shares a group of positively selected genes involved in sugar, lipid, and iron metabolism. Interestingly, in fruit-nectar–feeding Phyllostomid and Pteropodids bats, we detected positive selection in two genes: AACS and ALKBH7, which are crucial in sugar and fat metabolism. Moreover, in these two proteins we found parallel amino acid substitutions in conserved positions exclusive to the tribe Glossophagini and to Pteropodids. CONCLUSIONS: Our findings illuminate the genomic and molecular shifts associated with the evolution of nectarivory and shed light on how nectar-feeding bats can avoid the adverse effects of diets with high glucose content. Oxford University Press 2020-06-06 /pmc/articles/PMC7276932/ /pubmed/32510151 http://dx.doi.org/10.1093/gigascience/giaa059 Text en © The Author(s) 2020. Published by Oxford University Press. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Gutiérrez-Guerrero, Yocelyn T
Ibarra-Laclette, Enrique
Martínez del Río, Carlos
Barrera-Redondo, Josué
Rebollar, Eria A
Ortega, Jorge
León-Paniagua, Livia
Urrutia, Araxi
Aguirre-Planter, Erika
Eguiarte, Luis E
Genomic consequences of dietary diversification and parallel evolution due to nectarivory in leaf-nosed bats
title Genomic consequences of dietary diversification and parallel evolution due to nectarivory in leaf-nosed bats
title_full Genomic consequences of dietary diversification and parallel evolution due to nectarivory in leaf-nosed bats
title_fullStr Genomic consequences of dietary diversification and parallel evolution due to nectarivory in leaf-nosed bats
title_full_unstemmed Genomic consequences of dietary diversification and parallel evolution due to nectarivory in leaf-nosed bats
title_short Genomic consequences of dietary diversification and parallel evolution due to nectarivory in leaf-nosed bats
title_sort genomic consequences of dietary diversification and parallel evolution due to nectarivory in leaf-nosed bats
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7276932/
https://www.ncbi.nlm.nih.gov/pubmed/32510151
http://dx.doi.org/10.1093/gigascience/giaa059
work_keys_str_mv AT gutierrezguerreroyocelynt genomicconsequencesofdietarydiversificationandparallelevolutionduetonectarivoryinleafnosedbats
AT ibarralacletteenrique genomicconsequencesofdietarydiversificationandparallelevolutionduetonectarivoryinleafnosedbats
AT martinezdelriocarlos genomicconsequencesofdietarydiversificationandparallelevolutionduetonectarivoryinleafnosedbats
AT barreraredondojosue genomicconsequencesofdietarydiversificationandparallelevolutionduetonectarivoryinleafnosedbats
AT rebollareriaa genomicconsequencesofdietarydiversificationandparallelevolutionduetonectarivoryinleafnosedbats
AT ortegajorge genomicconsequencesofdietarydiversificationandparallelevolutionduetonectarivoryinleafnosedbats
AT leonpaniagualivia genomicconsequencesofdietarydiversificationandparallelevolutionduetonectarivoryinleafnosedbats
AT urrutiaaraxi genomicconsequencesofdietarydiversificationandparallelevolutionduetonectarivoryinleafnosedbats
AT aguirreplantererika genomicconsequencesofdietarydiversificationandparallelevolutionduetonectarivoryinleafnosedbats
AT eguiarteluise genomicconsequencesofdietarydiversificationandparallelevolutionduetonectarivoryinleafnosedbats