Melleins—Intriguing Natural Compounds

Melleins are 3,4-dihydroisocoumarins mainly produced by fungi, but also by plants, insects and bacteria. These specialized metabolites play important roles in the life cycles of the producers and they are involved in many biochemical and ecological processes. This review outlines the isolation and c...

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Detalles Bibliográficos
Autores principales: Reveglia, Pierluigi, Masi, Marco, Evidente, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7277180/
https://www.ncbi.nlm.nih.gov/pubmed/32429259
http://dx.doi.org/10.3390/biom10050772
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author Reveglia, Pierluigi
Masi, Marco
Evidente, Antonio
author_facet Reveglia, Pierluigi
Masi, Marco
Evidente, Antonio
author_sort Reveglia, Pierluigi
collection PubMed
description Melleins are 3,4-dihydroisocoumarins mainly produced by fungi, but also by plants, insects and bacteria. These specialized metabolites play important roles in the life cycles of the producers and they are involved in many biochemical and ecological processes. This review outlines the isolation and chemical and biological characterizations of natural-occurring melleins from the first report of (R)-mellein in 1933 to the most recent advances in their characterization in 2019. In addition, the pathways that could be involved in mellein biosynthesis are discussed, along with the enzymes and genes involved.
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spelling pubmed-72771802020-06-15 Melleins—Intriguing Natural Compounds Reveglia, Pierluigi Masi, Marco Evidente, Antonio Biomolecules Review Melleins are 3,4-dihydroisocoumarins mainly produced by fungi, but also by plants, insects and bacteria. These specialized metabolites play important roles in the life cycles of the producers and they are involved in many biochemical and ecological processes. This review outlines the isolation and chemical and biological characterizations of natural-occurring melleins from the first report of (R)-mellein in 1933 to the most recent advances in their characterization in 2019. In addition, the pathways that could be involved in mellein biosynthesis are discussed, along with the enzymes and genes involved. MDPI 2020-05-15 /pmc/articles/PMC7277180/ /pubmed/32429259 http://dx.doi.org/10.3390/biom10050772 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Reveglia, Pierluigi
Masi, Marco
Evidente, Antonio
Melleins—Intriguing Natural Compounds
title Melleins—Intriguing Natural Compounds
title_full Melleins—Intriguing Natural Compounds
title_fullStr Melleins—Intriguing Natural Compounds
title_full_unstemmed Melleins—Intriguing Natural Compounds
title_short Melleins—Intriguing Natural Compounds
title_sort melleins—intriguing natural compounds
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7277180/
https://www.ncbi.nlm.nih.gov/pubmed/32429259
http://dx.doi.org/10.3390/biom10050772
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