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Can the Molar Insulin: C-Peptide Ratio Be Used to Predict Hyperinsulinaemia?

Hyperinsulinaemia is the precursor to numerous metabolic disorders. Early diagnosis and intervention could improve population health. Diagnosing hyperinsulinaemia is problematic because insulin has a very short half-life (2–5 min). It is theorised that c-peptide levels (half-life 20–30 min) would be...

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Autores principales: Guildford, Lynda, Crofts, Catherine, Lu, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7277201/
https://www.ncbi.nlm.nih.gov/pubmed/32375229
http://dx.doi.org/10.3390/biomedicines8050108
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author Guildford, Lynda
Crofts, Catherine
Lu, Jun
author_facet Guildford, Lynda
Crofts, Catherine
Lu, Jun
author_sort Guildford, Lynda
collection PubMed
description Hyperinsulinaemia is the precursor to numerous metabolic disorders. Early diagnosis and intervention could improve population health. Diagnosing hyperinsulinaemia is problematic because insulin has a very short half-life (2–5 min). It is theorised that c-peptide levels (half-life 20–30 min) would be a better proxy for insulin due to both hormones being released in equimolar amounts. However, the correlation between c-peptide and insulin levels is unknown. We aim to identify their correlation following a four-hour oral glucose tolerance test (OGTT). Data were obtained from records of routine medical care at St Joseph’s Hospital, Chicago, IL, USA, during 1977. Two hundred and fifty-five male and female participants aged over 20 years undertook a four-hour OGTT with plasma glucose, insulin and c-peptide levels recorded. Correlation was assessed with Pearson’s correlation. There was a weak correlation between insulin and c-peptide, which increased to moderate across the four-hour OGTT (r = 0.482–0.680). There was no significant change in this relationship when data was subdivided according to either the WHO glucose status or Kraft insulin response. Although there was a correlation between insulin and c-peptide, it was too weak to recommend the use of c-peptide as an alternative biomarker for the diagnosis of hyperinsulinaemia.
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spelling pubmed-72772012020-06-15 Can the Molar Insulin: C-Peptide Ratio Be Used to Predict Hyperinsulinaemia? Guildford, Lynda Crofts, Catherine Lu, Jun Biomedicines Article Hyperinsulinaemia is the precursor to numerous metabolic disorders. Early diagnosis and intervention could improve population health. Diagnosing hyperinsulinaemia is problematic because insulin has a very short half-life (2–5 min). It is theorised that c-peptide levels (half-life 20–30 min) would be a better proxy for insulin due to both hormones being released in equimolar amounts. However, the correlation between c-peptide and insulin levels is unknown. We aim to identify their correlation following a four-hour oral glucose tolerance test (OGTT). Data were obtained from records of routine medical care at St Joseph’s Hospital, Chicago, IL, USA, during 1977. Two hundred and fifty-five male and female participants aged over 20 years undertook a four-hour OGTT with plasma glucose, insulin and c-peptide levels recorded. Correlation was assessed with Pearson’s correlation. There was a weak correlation between insulin and c-peptide, which increased to moderate across the four-hour OGTT (r = 0.482–0.680). There was no significant change in this relationship when data was subdivided according to either the WHO glucose status or Kraft insulin response. Although there was a correlation between insulin and c-peptide, it was too weak to recommend the use of c-peptide as an alternative biomarker for the diagnosis of hyperinsulinaemia. MDPI 2020-05-03 /pmc/articles/PMC7277201/ /pubmed/32375229 http://dx.doi.org/10.3390/biomedicines8050108 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Guildford, Lynda
Crofts, Catherine
Lu, Jun
Can the Molar Insulin: C-Peptide Ratio Be Used to Predict Hyperinsulinaemia?
title Can the Molar Insulin: C-Peptide Ratio Be Used to Predict Hyperinsulinaemia?
title_full Can the Molar Insulin: C-Peptide Ratio Be Used to Predict Hyperinsulinaemia?
title_fullStr Can the Molar Insulin: C-Peptide Ratio Be Used to Predict Hyperinsulinaemia?
title_full_unstemmed Can the Molar Insulin: C-Peptide Ratio Be Used to Predict Hyperinsulinaemia?
title_short Can the Molar Insulin: C-Peptide Ratio Be Used to Predict Hyperinsulinaemia?
title_sort can the molar insulin: c-peptide ratio be used to predict hyperinsulinaemia?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7277201/
https://www.ncbi.nlm.nih.gov/pubmed/32375229
http://dx.doi.org/10.3390/biomedicines8050108
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