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Can the Molar Insulin: C-Peptide Ratio Be Used to Predict Hyperinsulinaemia?
Hyperinsulinaemia is the precursor to numerous metabolic disorders. Early diagnosis and intervention could improve population health. Diagnosing hyperinsulinaemia is problematic because insulin has a very short half-life (2–5 min). It is theorised that c-peptide levels (half-life 20–30 min) would be...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7277201/ https://www.ncbi.nlm.nih.gov/pubmed/32375229 http://dx.doi.org/10.3390/biomedicines8050108 |
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author | Guildford, Lynda Crofts, Catherine Lu, Jun |
author_facet | Guildford, Lynda Crofts, Catherine Lu, Jun |
author_sort | Guildford, Lynda |
collection | PubMed |
description | Hyperinsulinaemia is the precursor to numerous metabolic disorders. Early diagnosis and intervention could improve population health. Diagnosing hyperinsulinaemia is problematic because insulin has a very short half-life (2–5 min). It is theorised that c-peptide levels (half-life 20–30 min) would be a better proxy for insulin due to both hormones being released in equimolar amounts. However, the correlation between c-peptide and insulin levels is unknown. We aim to identify their correlation following a four-hour oral glucose tolerance test (OGTT). Data were obtained from records of routine medical care at St Joseph’s Hospital, Chicago, IL, USA, during 1977. Two hundred and fifty-five male and female participants aged over 20 years undertook a four-hour OGTT with plasma glucose, insulin and c-peptide levels recorded. Correlation was assessed with Pearson’s correlation. There was a weak correlation between insulin and c-peptide, which increased to moderate across the four-hour OGTT (r = 0.482–0.680). There was no significant change in this relationship when data was subdivided according to either the WHO glucose status or Kraft insulin response. Although there was a correlation between insulin and c-peptide, it was too weak to recommend the use of c-peptide as an alternative biomarker for the diagnosis of hyperinsulinaemia. |
format | Online Article Text |
id | pubmed-7277201 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-72772012020-06-15 Can the Molar Insulin: C-Peptide Ratio Be Used to Predict Hyperinsulinaemia? Guildford, Lynda Crofts, Catherine Lu, Jun Biomedicines Article Hyperinsulinaemia is the precursor to numerous metabolic disorders. Early diagnosis and intervention could improve population health. Diagnosing hyperinsulinaemia is problematic because insulin has a very short half-life (2–5 min). It is theorised that c-peptide levels (half-life 20–30 min) would be a better proxy for insulin due to both hormones being released in equimolar amounts. However, the correlation between c-peptide and insulin levels is unknown. We aim to identify their correlation following a four-hour oral glucose tolerance test (OGTT). Data were obtained from records of routine medical care at St Joseph’s Hospital, Chicago, IL, USA, during 1977. Two hundred and fifty-five male and female participants aged over 20 years undertook a four-hour OGTT with plasma glucose, insulin and c-peptide levels recorded. Correlation was assessed with Pearson’s correlation. There was a weak correlation between insulin and c-peptide, which increased to moderate across the four-hour OGTT (r = 0.482–0.680). There was no significant change in this relationship when data was subdivided according to either the WHO glucose status or Kraft insulin response. Although there was a correlation between insulin and c-peptide, it was too weak to recommend the use of c-peptide as an alternative biomarker for the diagnosis of hyperinsulinaemia. MDPI 2020-05-03 /pmc/articles/PMC7277201/ /pubmed/32375229 http://dx.doi.org/10.3390/biomedicines8050108 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Guildford, Lynda Crofts, Catherine Lu, Jun Can the Molar Insulin: C-Peptide Ratio Be Used to Predict Hyperinsulinaemia? |
title | Can the Molar Insulin: C-Peptide Ratio Be Used to Predict Hyperinsulinaemia? |
title_full | Can the Molar Insulin: C-Peptide Ratio Be Used to Predict Hyperinsulinaemia? |
title_fullStr | Can the Molar Insulin: C-Peptide Ratio Be Used to Predict Hyperinsulinaemia? |
title_full_unstemmed | Can the Molar Insulin: C-Peptide Ratio Be Used to Predict Hyperinsulinaemia? |
title_short | Can the Molar Insulin: C-Peptide Ratio Be Used to Predict Hyperinsulinaemia? |
title_sort | can the molar insulin: c-peptide ratio be used to predict hyperinsulinaemia? |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7277201/ https://www.ncbi.nlm.nih.gov/pubmed/32375229 http://dx.doi.org/10.3390/biomedicines8050108 |
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