Divalent cations bind to phosphoinositides to induce ion and isomer specific propensities for nano-cluster initiation in bilayer membranes

We report all-atom molecular dynamics simulations of asymmetric bilayers containing phosphoinositides in the presence of monovalent and divalent cations. We have characterized the molecular mechanism by which these divalent cations interact with phosphoinositides. Ca(2+) desolvates more readily, con...

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Detalles Bibliográficos
Autores principales: Bradley, Ryan P., Slochower, David R., Janmey, Paul A., Radhakrishnan, Ravi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2020
Materias:
Physics and Biophysics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7277276/
https://www.ncbi.nlm.nih.gov/pubmed/32537210
http://dx.doi.org/10.1098/rsos.192208

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7277276/
https://www.ncbi.nlm.nih.gov/pubmed/32537210
http://dx.doi.org/10.1098/rsos.192208

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