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The Influence of Selected Gastrointestinal Parasites on Apoptosis in Intestinal Epithelial Cells
Studies on the parasite–host interaction may provide valuable information concerning the modulation of molecular mechanisms as well as of the host immune system during infection. To date, it has been demonstrated that intestinal parasites may affect, among others, the processes of digestion in the g...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7277436/ https://www.ncbi.nlm.nih.gov/pubmed/32349424 http://dx.doi.org/10.3390/biom10050674 |
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author | Kapczuk, Patrycja Kosik-Bogacka, Danuta Kupnicka, Patrycja Metryka, Emilia Simińska, Donata Rogulska, Karolina Skórka-Majewicz, Marta Gutowska, Izabela Chlubek, Dariusz Baranowska-Bosiacka, Irena |
author_facet | Kapczuk, Patrycja Kosik-Bogacka, Danuta Kupnicka, Patrycja Metryka, Emilia Simińska, Donata Rogulska, Karolina Skórka-Majewicz, Marta Gutowska, Izabela Chlubek, Dariusz Baranowska-Bosiacka, Irena |
author_sort | Kapczuk, Patrycja |
collection | PubMed |
description | Studies on the parasite–host interaction may provide valuable information concerning the modulation of molecular mechanisms as well as of the host immune system during infection. To date, it has been demonstrated that intestinal parasites may affect, among others, the processes of digestion in the gastrointestinal system of the host, thus limiting the elimination of the parasite, the immune response as well as inflammation. However, the most recent studies suggest that intestinal parasites may also affect modulation of the apoptosis pathway of the host. The present paper presents the latest scientific information on the influence of intestinal parasite species (Blastocystis sp., Giardia sp., Cryptosporidium sp., Trichuris sp., Entamoeba histolytica, Nippostrongylus brasiliensis, Heligmosomoides polygyrus) on the molecular mechanisms of apoptosis in intestinal epithelial cells. This paper stresses that the interdependency between the intestinal parasite and the host results from the direct effect of the parasite and the host’s defense reactions, which lead to modulation of the apoptosis pathways (intrinsic and extrinsic). Moreover, the present paper presents the role of proteins involved in the mechanisms of apoptosis as well as the physiological role of apoptosis in the host’s intestinal epithelial cells. |
format | Online Article Text |
id | pubmed-7277436 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-72774362020-06-15 The Influence of Selected Gastrointestinal Parasites on Apoptosis in Intestinal Epithelial Cells Kapczuk, Patrycja Kosik-Bogacka, Danuta Kupnicka, Patrycja Metryka, Emilia Simińska, Donata Rogulska, Karolina Skórka-Majewicz, Marta Gutowska, Izabela Chlubek, Dariusz Baranowska-Bosiacka, Irena Biomolecules Review Studies on the parasite–host interaction may provide valuable information concerning the modulation of molecular mechanisms as well as of the host immune system during infection. To date, it has been demonstrated that intestinal parasites may affect, among others, the processes of digestion in the gastrointestinal system of the host, thus limiting the elimination of the parasite, the immune response as well as inflammation. However, the most recent studies suggest that intestinal parasites may also affect modulation of the apoptosis pathway of the host. The present paper presents the latest scientific information on the influence of intestinal parasite species (Blastocystis sp., Giardia sp., Cryptosporidium sp., Trichuris sp., Entamoeba histolytica, Nippostrongylus brasiliensis, Heligmosomoides polygyrus) on the molecular mechanisms of apoptosis in intestinal epithelial cells. This paper stresses that the interdependency between the intestinal parasite and the host results from the direct effect of the parasite and the host’s defense reactions, which lead to modulation of the apoptosis pathways (intrinsic and extrinsic). Moreover, the present paper presents the role of proteins involved in the mechanisms of apoptosis as well as the physiological role of apoptosis in the host’s intestinal epithelial cells. MDPI 2020-04-27 /pmc/articles/PMC7277436/ /pubmed/32349424 http://dx.doi.org/10.3390/biom10050674 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Kapczuk, Patrycja Kosik-Bogacka, Danuta Kupnicka, Patrycja Metryka, Emilia Simińska, Donata Rogulska, Karolina Skórka-Majewicz, Marta Gutowska, Izabela Chlubek, Dariusz Baranowska-Bosiacka, Irena The Influence of Selected Gastrointestinal Parasites on Apoptosis in Intestinal Epithelial Cells |
title | The Influence of Selected Gastrointestinal Parasites on Apoptosis in Intestinal Epithelial Cells |
title_full | The Influence of Selected Gastrointestinal Parasites on Apoptosis in Intestinal Epithelial Cells |
title_fullStr | The Influence of Selected Gastrointestinal Parasites on Apoptosis in Intestinal Epithelial Cells |
title_full_unstemmed | The Influence of Selected Gastrointestinal Parasites on Apoptosis in Intestinal Epithelial Cells |
title_short | The Influence of Selected Gastrointestinal Parasites on Apoptosis in Intestinal Epithelial Cells |
title_sort | influence of selected gastrointestinal parasites on apoptosis in intestinal epithelial cells |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7277436/ https://www.ncbi.nlm.nih.gov/pubmed/32349424 http://dx.doi.org/10.3390/biom10050674 |
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