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Chronic Periodontitis Is Associated with the Risk of Bipolar Disorder: A Population-Based Cohort Study

Bipolar disorder (BD) is a psychiatric mood disturbance manifested by manic, hypomanic, or major depressive periods. Chronic inflammation was evidenced as an important etiologic factor of BD. Chronic periodontitis (CP) is an inflammatory disease triggered by bacterial products, leading to the destru...

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Detalles Bibliográficos
Autores principales: Huang, Yung-Kai, Wang, Yu-Hsun, Chang, Yu-Chao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7277490/
https://www.ncbi.nlm.nih.gov/pubmed/32429260
http://dx.doi.org/10.3390/ijerph17103466
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author Huang, Yung-Kai
Wang, Yu-Hsun
Chang, Yu-Chao
author_facet Huang, Yung-Kai
Wang, Yu-Hsun
Chang, Yu-Chao
author_sort Huang, Yung-Kai
collection PubMed
description Bipolar disorder (BD) is a psychiatric mood disturbance manifested by manic, hypomanic, or major depressive periods. Chronic inflammation was evidenced as an important etiologic factor of BD. Chronic periodontitis (CP) is an inflammatory disease triggered by bacterial products, leading to the destruction of periodontium. The relationship between BD and CP is of interest to investigate. Therefore, a nationwide population-based cohort study was used to investigate the risk of BD and CP exposure from 2001 to 2012. We identified 61,608 patients with CP from the Taiwanese National Health Insurance Research Database (NHIRD). The 123,216 controls were randomly captured and matched by age, sex, index year, and co-morbidities. The association between CP exposure and BD risk was examined by Cox proportional hazards regression models. In this study, 61,608 CP patients and 123,216 controls were followed up for 7.45 and 7.36 years, respectively. In total, 138 BD patients were identified in the CP cohort and 187 BD cases were found in the non-CP cohort. The incidence rate of BD was significantly higher in the CP cohort than in the non-CP cohort (adjusted HR: 1.46, 95% CI: 1.17–1.81) according to the multivariate Cox regression analysis. Females had a 1.47-fold increased risk (95% CI: 1.16–1.86) for BD compared to males. Taken together, CP may be associated with an increased risk of subsequent BD in Taiwan.
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spelling pubmed-72774902020-06-12 Chronic Periodontitis Is Associated with the Risk of Bipolar Disorder: A Population-Based Cohort Study Huang, Yung-Kai Wang, Yu-Hsun Chang, Yu-Chao Int J Environ Res Public Health Article Bipolar disorder (BD) is a psychiatric mood disturbance manifested by manic, hypomanic, or major depressive periods. Chronic inflammation was evidenced as an important etiologic factor of BD. Chronic periodontitis (CP) is an inflammatory disease triggered by bacterial products, leading to the destruction of periodontium. The relationship between BD and CP is of interest to investigate. Therefore, a nationwide population-based cohort study was used to investigate the risk of BD and CP exposure from 2001 to 2012. We identified 61,608 patients with CP from the Taiwanese National Health Insurance Research Database (NHIRD). The 123,216 controls were randomly captured and matched by age, sex, index year, and co-morbidities. The association between CP exposure and BD risk was examined by Cox proportional hazards regression models. In this study, 61,608 CP patients and 123,216 controls were followed up for 7.45 and 7.36 years, respectively. In total, 138 BD patients were identified in the CP cohort and 187 BD cases were found in the non-CP cohort. The incidence rate of BD was significantly higher in the CP cohort than in the non-CP cohort (adjusted HR: 1.46, 95% CI: 1.17–1.81) according to the multivariate Cox regression analysis. Females had a 1.47-fold increased risk (95% CI: 1.16–1.86) for BD compared to males. Taken together, CP may be associated with an increased risk of subsequent BD in Taiwan. MDPI 2020-05-15 2020-05 /pmc/articles/PMC7277490/ /pubmed/32429260 http://dx.doi.org/10.3390/ijerph17103466 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Huang, Yung-Kai
Wang, Yu-Hsun
Chang, Yu-Chao
Chronic Periodontitis Is Associated with the Risk of Bipolar Disorder: A Population-Based Cohort Study
title Chronic Periodontitis Is Associated with the Risk of Bipolar Disorder: A Population-Based Cohort Study
title_full Chronic Periodontitis Is Associated with the Risk of Bipolar Disorder: A Population-Based Cohort Study
title_fullStr Chronic Periodontitis Is Associated with the Risk of Bipolar Disorder: A Population-Based Cohort Study
title_full_unstemmed Chronic Periodontitis Is Associated with the Risk of Bipolar Disorder: A Population-Based Cohort Study
title_short Chronic Periodontitis Is Associated with the Risk of Bipolar Disorder: A Population-Based Cohort Study
title_sort chronic periodontitis is associated with the risk of bipolar disorder: a population-based cohort study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7277490/
https://www.ncbi.nlm.nih.gov/pubmed/32429260
http://dx.doi.org/10.3390/ijerph17103466
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