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Yeast-Based Biosensors: Current Applications and New Developments
Biosensors are regarded as a powerful tool to detect and monitor environmental contaminants, toxins, and, more generally, organic or chemical markers of potential threats to human health. They are basically composed of a sensor part made up of either live cells or biological active molecules coupled...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7277604/ https://www.ncbi.nlm.nih.gov/pubmed/32413968 http://dx.doi.org/10.3390/bios10050051 |
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author | Martin-Yken, Helene |
author_facet | Martin-Yken, Helene |
author_sort | Martin-Yken, Helene |
collection | PubMed |
description | Biosensors are regarded as a powerful tool to detect and monitor environmental contaminants, toxins, and, more generally, organic or chemical markers of potential threats to human health. They are basically composed of a sensor part made up of either live cells or biological active molecules coupled to a transducer/reporter technological element. Whole-cells biosensors may be based on animal tissues, bacteria, or eukaryotic microorganisms such as yeasts and microalgae. Although very resistant to adverse environmental conditions, yeasts can sense and respond to a wide variety of stimuli. As eukaryotes, they also constitute excellent cellular models to detect chemicals and organic contaminants that are harmful to animals. For these reasons, combined with their ease of culture and genetic modification, yeasts have been commonly used as biological elements of biosensors since the 1970s. This review aims first at giving a survey on the different types of yeast-based biosensors developed for the environmental and medical domains. We then present the technological developments currently undertaken by academic and corporate scientists to further drive yeasts biosensors into a new era where the biological element is optimized in a tailor-made fashion by in silico design and where the output signals can be recorded or followed on a smartphone. |
format | Online Article Text |
id | pubmed-7277604 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-72776042020-06-12 Yeast-Based Biosensors: Current Applications and New Developments Martin-Yken, Helene Biosensors (Basel) Review Biosensors are regarded as a powerful tool to detect and monitor environmental contaminants, toxins, and, more generally, organic or chemical markers of potential threats to human health. They are basically composed of a sensor part made up of either live cells or biological active molecules coupled to a transducer/reporter technological element. Whole-cells biosensors may be based on animal tissues, bacteria, or eukaryotic microorganisms such as yeasts and microalgae. Although very resistant to adverse environmental conditions, yeasts can sense and respond to a wide variety of stimuli. As eukaryotes, they also constitute excellent cellular models to detect chemicals and organic contaminants that are harmful to animals. For these reasons, combined with their ease of culture and genetic modification, yeasts have been commonly used as biological elements of biosensors since the 1970s. This review aims first at giving a survey on the different types of yeast-based biosensors developed for the environmental and medical domains. We then present the technological developments currently undertaken by academic and corporate scientists to further drive yeasts biosensors into a new era where the biological element is optimized in a tailor-made fashion by in silico design and where the output signals can be recorded or followed on a smartphone. MDPI 2020-05-13 /pmc/articles/PMC7277604/ /pubmed/32413968 http://dx.doi.org/10.3390/bios10050051 Text en © 2020 by the author. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Martin-Yken, Helene Yeast-Based Biosensors: Current Applications and New Developments |
title | Yeast-Based Biosensors: Current Applications and New Developments |
title_full | Yeast-Based Biosensors: Current Applications and New Developments |
title_fullStr | Yeast-Based Biosensors: Current Applications and New Developments |
title_full_unstemmed | Yeast-Based Biosensors: Current Applications and New Developments |
title_short | Yeast-Based Biosensors: Current Applications and New Developments |
title_sort | yeast-based biosensors: current applications and new developments |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7277604/ https://www.ncbi.nlm.nih.gov/pubmed/32413968 http://dx.doi.org/10.3390/bios10050051 |
work_keys_str_mv | AT martinykenhelene yeastbasedbiosensorscurrentapplicationsandnewdevelopments |