The NRF2/KEAP1 Axis in the Regulation of Tumor Metabolism: Mechanisms and Therapeutic Perspectives

The NRF2/KEAP1 pathway is a fundamental signaling cascade that controls multiple cytoprotective responses through the induction of a complex transcriptional program that ultimately renders cancer cells resistant to oxidative, metabolic and therapeutic stress. Interestingly, accumulating evidence in...

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Detalles Bibliográficos
Autores principales: Panieri, Emiliano, Telkoparan-Akillilar, Pelin, Suzen, Sibel, Saso, Luciano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7277620/
https://www.ncbi.nlm.nih.gov/pubmed/32443774
http://dx.doi.org/10.3390/biom10050791
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author Panieri, Emiliano
Telkoparan-Akillilar, Pelin
Suzen, Sibel
Saso, Luciano
author_facet Panieri, Emiliano
Telkoparan-Akillilar, Pelin
Suzen, Sibel
Saso, Luciano
author_sort Panieri, Emiliano
collection PubMed
description The NRF2/KEAP1 pathway is a fundamental signaling cascade that controls multiple cytoprotective responses through the induction of a complex transcriptional program that ultimately renders cancer cells resistant to oxidative, metabolic and therapeutic stress. Interestingly, accumulating evidence in recent years has indicated that metabolic reprogramming is closely interrelated with the regulation of redox homeostasis, suggesting that the disruption of NRF2 signaling might represent a valid therapeutic strategy against a variety of solid and hematologic cancers. These aspects will be the focus of the present review.
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spelling pubmed-72776202020-06-12 The NRF2/KEAP1 Axis in the Regulation of Tumor Metabolism: Mechanisms and Therapeutic Perspectives Panieri, Emiliano Telkoparan-Akillilar, Pelin Suzen, Sibel Saso, Luciano Biomolecules Review The NRF2/KEAP1 pathway is a fundamental signaling cascade that controls multiple cytoprotective responses through the induction of a complex transcriptional program that ultimately renders cancer cells resistant to oxidative, metabolic and therapeutic stress. Interestingly, accumulating evidence in recent years has indicated that metabolic reprogramming is closely interrelated with the regulation of redox homeostasis, suggesting that the disruption of NRF2 signaling might represent a valid therapeutic strategy against a variety of solid and hematologic cancers. These aspects will be the focus of the present review. MDPI 2020-05-20 /pmc/articles/PMC7277620/ /pubmed/32443774 http://dx.doi.org/10.3390/biom10050791 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Panieri, Emiliano
Telkoparan-Akillilar, Pelin
Suzen, Sibel
Saso, Luciano
The NRF2/KEAP1 Axis in the Regulation of Tumor Metabolism: Mechanisms and Therapeutic Perspectives
title The NRF2/KEAP1 Axis in the Regulation of Tumor Metabolism: Mechanisms and Therapeutic Perspectives
title_full The NRF2/KEAP1 Axis in the Regulation of Tumor Metabolism: Mechanisms and Therapeutic Perspectives
title_fullStr The NRF2/KEAP1 Axis in the Regulation of Tumor Metabolism: Mechanisms and Therapeutic Perspectives
title_full_unstemmed The NRF2/KEAP1 Axis in the Regulation of Tumor Metabolism: Mechanisms and Therapeutic Perspectives
title_short The NRF2/KEAP1 Axis in the Regulation of Tumor Metabolism: Mechanisms and Therapeutic Perspectives
title_sort nrf2/keap1 axis in the regulation of tumor metabolism: mechanisms and therapeutic perspectives
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7277620/
https://www.ncbi.nlm.nih.gov/pubmed/32443774
http://dx.doi.org/10.3390/biom10050791
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