Cargando…

The Role of IL-6 in Skin Fibrosis and Cutaneous Wound Healing

The timely resolution of wound healing is critical for restoring the skin as a protective barrier. The switch from a proinflammatory to a reparative microenvironment must be tightly regulated. Interleukin (IL)-6 is a key modulator of the inflammatory and reparative process: it is involved in the dif...

Descripción completa

Detalles Bibliográficos
Autores principales: Johnson, Blair Z., Stevenson, Andrew W., Prêle, Cecilia M., Fear, Mark W., Wood, Fiona M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7277690/
https://www.ncbi.nlm.nih.gov/pubmed/32365896
http://dx.doi.org/10.3390/biomedicines8050101
_version_ 1783543177000517632
author Johnson, Blair Z.
Stevenson, Andrew W.
Prêle, Cecilia M.
Fear, Mark W.
Wood, Fiona M.
author_facet Johnson, Blair Z.
Stevenson, Andrew W.
Prêle, Cecilia M.
Fear, Mark W.
Wood, Fiona M.
author_sort Johnson, Blair Z.
collection PubMed
description The timely resolution of wound healing is critical for restoring the skin as a protective barrier. The switch from a proinflammatory to a reparative microenvironment must be tightly regulated. Interleukin (IL)-6 is a key modulator of the inflammatory and reparative process: it is involved in the differentiation, activation, and proliferation of leukocytes, endothelial cells, keratinocytes, and fibroblasts. This review examines the role of IL-6 in the healing of cutaneous wounds, and how dysregulation of IL-6 signaling can lead to either fibrosis or a failure to heal. The role of an IL-6/TGF-β feedback loop is discussed in the context of fibrogenesis, while IL-6 expression and responses in advanced age, diabetes, and obesity is outlined regarding the development of chronic wounds. Current research on therapies that modulate IL-6 is explored. Here, we consider IL-6′s diverse impact on cutaneous wound healing.
format Online
Article
Text
id pubmed-7277690
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-72776902020-06-12 The Role of IL-6 in Skin Fibrosis and Cutaneous Wound Healing Johnson, Blair Z. Stevenson, Andrew W. Prêle, Cecilia M. Fear, Mark W. Wood, Fiona M. Biomedicines Review The timely resolution of wound healing is critical for restoring the skin as a protective barrier. The switch from a proinflammatory to a reparative microenvironment must be tightly regulated. Interleukin (IL)-6 is a key modulator of the inflammatory and reparative process: it is involved in the differentiation, activation, and proliferation of leukocytes, endothelial cells, keratinocytes, and fibroblasts. This review examines the role of IL-6 in the healing of cutaneous wounds, and how dysregulation of IL-6 signaling can lead to either fibrosis or a failure to heal. The role of an IL-6/TGF-β feedback loop is discussed in the context of fibrogenesis, while IL-6 expression and responses in advanced age, diabetes, and obesity is outlined regarding the development of chronic wounds. Current research on therapies that modulate IL-6 is explored. Here, we consider IL-6′s diverse impact on cutaneous wound healing. MDPI 2020-04-30 /pmc/articles/PMC7277690/ /pubmed/32365896 http://dx.doi.org/10.3390/biomedicines8050101 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Johnson, Blair Z.
Stevenson, Andrew W.
Prêle, Cecilia M.
Fear, Mark W.
Wood, Fiona M.
The Role of IL-6 in Skin Fibrosis and Cutaneous Wound Healing
title The Role of IL-6 in Skin Fibrosis and Cutaneous Wound Healing
title_full The Role of IL-6 in Skin Fibrosis and Cutaneous Wound Healing
title_fullStr The Role of IL-6 in Skin Fibrosis and Cutaneous Wound Healing
title_full_unstemmed The Role of IL-6 in Skin Fibrosis and Cutaneous Wound Healing
title_short The Role of IL-6 in Skin Fibrosis and Cutaneous Wound Healing
title_sort role of il-6 in skin fibrosis and cutaneous wound healing
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7277690/
https://www.ncbi.nlm.nih.gov/pubmed/32365896
http://dx.doi.org/10.3390/biomedicines8050101
work_keys_str_mv AT johnsonblairz theroleofil6inskinfibrosisandcutaneouswoundhealing
AT stevensonandreww theroleofil6inskinfibrosisandcutaneouswoundhealing
AT prelececiliam theroleofil6inskinfibrosisandcutaneouswoundhealing
AT fearmarkw theroleofil6inskinfibrosisandcutaneouswoundhealing
AT woodfionam theroleofil6inskinfibrosisandcutaneouswoundhealing
AT johnsonblairz roleofil6inskinfibrosisandcutaneouswoundhealing
AT stevensonandreww roleofil6inskinfibrosisandcutaneouswoundhealing
AT prelececiliam roleofil6inskinfibrosisandcutaneouswoundhealing
AT fearmarkw roleofil6inskinfibrosisandcutaneouswoundhealing
AT woodfionam roleofil6inskinfibrosisandcutaneouswoundhealing