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The Role of IL-6 in Skin Fibrosis and Cutaneous Wound Healing
The timely resolution of wound healing is critical for restoring the skin as a protective barrier. The switch from a proinflammatory to a reparative microenvironment must be tightly regulated. Interleukin (IL)-6 is a key modulator of the inflammatory and reparative process: it is involved in the dif...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7277690/ https://www.ncbi.nlm.nih.gov/pubmed/32365896 http://dx.doi.org/10.3390/biomedicines8050101 |
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author | Johnson, Blair Z. Stevenson, Andrew W. Prêle, Cecilia M. Fear, Mark W. Wood, Fiona M. |
author_facet | Johnson, Blair Z. Stevenson, Andrew W. Prêle, Cecilia M. Fear, Mark W. Wood, Fiona M. |
author_sort | Johnson, Blair Z. |
collection | PubMed |
description | The timely resolution of wound healing is critical for restoring the skin as a protective barrier. The switch from a proinflammatory to a reparative microenvironment must be tightly regulated. Interleukin (IL)-6 is a key modulator of the inflammatory and reparative process: it is involved in the differentiation, activation, and proliferation of leukocytes, endothelial cells, keratinocytes, and fibroblasts. This review examines the role of IL-6 in the healing of cutaneous wounds, and how dysregulation of IL-6 signaling can lead to either fibrosis or a failure to heal. The role of an IL-6/TGF-β feedback loop is discussed in the context of fibrogenesis, while IL-6 expression and responses in advanced age, diabetes, and obesity is outlined regarding the development of chronic wounds. Current research on therapies that modulate IL-6 is explored. Here, we consider IL-6′s diverse impact on cutaneous wound healing. |
format | Online Article Text |
id | pubmed-7277690 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-72776902020-06-12 The Role of IL-6 in Skin Fibrosis and Cutaneous Wound Healing Johnson, Blair Z. Stevenson, Andrew W. Prêle, Cecilia M. Fear, Mark W. Wood, Fiona M. Biomedicines Review The timely resolution of wound healing is critical for restoring the skin as a protective barrier. The switch from a proinflammatory to a reparative microenvironment must be tightly regulated. Interleukin (IL)-6 is a key modulator of the inflammatory and reparative process: it is involved in the differentiation, activation, and proliferation of leukocytes, endothelial cells, keratinocytes, and fibroblasts. This review examines the role of IL-6 in the healing of cutaneous wounds, and how dysregulation of IL-6 signaling can lead to either fibrosis or a failure to heal. The role of an IL-6/TGF-β feedback loop is discussed in the context of fibrogenesis, while IL-6 expression and responses in advanced age, diabetes, and obesity is outlined regarding the development of chronic wounds. Current research on therapies that modulate IL-6 is explored. Here, we consider IL-6′s diverse impact on cutaneous wound healing. MDPI 2020-04-30 /pmc/articles/PMC7277690/ /pubmed/32365896 http://dx.doi.org/10.3390/biomedicines8050101 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Johnson, Blair Z. Stevenson, Andrew W. Prêle, Cecilia M. Fear, Mark W. Wood, Fiona M. The Role of IL-6 in Skin Fibrosis and Cutaneous Wound Healing |
title | The Role of IL-6 in Skin Fibrosis and Cutaneous Wound Healing |
title_full | The Role of IL-6 in Skin Fibrosis and Cutaneous Wound Healing |
title_fullStr | The Role of IL-6 in Skin Fibrosis and Cutaneous Wound Healing |
title_full_unstemmed | The Role of IL-6 in Skin Fibrosis and Cutaneous Wound Healing |
title_short | The Role of IL-6 in Skin Fibrosis and Cutaneous Wound Healing |
title_sort | role of il-6 in skin fibrosis and cutaneous wound healing |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7277690/ https://www.ncbi.nlm.nih.gov/pubmed/32365896 http://dx.doi.org/10.3390/biomedicines8050101 |
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