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Aristolochia trilobata: Identification of the Anti-Inflammatory and Antinociceptive Effects
Aristolochia trilobata, popularly known as “mil-homens,” is widely used for treatment of stomach aches, colic, asthma, pulmonary diseases, diabetes, and skin affection. We evaluated the antinociceptive and anti-inflammatory activities of the essential oil (EO) and the main constituent, 6-methyl-5-he...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7277703/ https://www.ncbi.nlm.nih.gov/pubmed/32384613 http://dx.doi.org/10.3390/biomedicines8050111 |
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author | Salomé, Dayana da Costa Cordeiro, Natália de Morais Valério, Tayná Sequeira Santos, Darlisson de Alexandria Alves, Péricles Barreto Alviano, Celuta Sales Moreno, Daniela Sales Alviano Fernandes, Patricia Dias |
author_facet | Salomé, Dayana da Costa Cordeiro, Natália de Morais Valério, Tayná Sequeira Santos, Darlisson de Alexandria Alves, Péricles Barreto Alviano, Celuta Sales Moreno, Daniela Sales Alviano Fernandes, Patricia Dias |
author_sort | Salomé, Dayana da Costa |
collection | PubMed |
description | Aristolochia trilobata, popularly known as “mil-homens,” is widely used for treatment of stomach aches, colic, asthma, pulmonary diseases, diabetes, and skin affection. We evaluated the antinociceptive and anti-inflammatory activities of the essential oil (EO) and the main constituent, 6-methyl-5-hepten-2-yl acetate (sulcatyl acetate, SA). EO and SA (1, 10, and 100 mg/kg, p.o.) were evaluated using chemical (formalin-induced licking) and thermal (hot-plate) models of nociception or inflammation (carrageenan-induced cell migration into the subcutaneous air pouch, SAP). The mechanism of antinociceptive activity was evaluated using opioid, cholinergic receptor antagonists (naloxone and atropine), or nitric oxide synthase inhibitor (L-NAME). EO and SA presented a central antinociceptive effect (the hot-plate model). In formalin-induced licking response, higher doses of EO and SA also reduced 1st and 2nd phases. None of the antagonists and enzyme inhibitor reversed antinociceptive effects. EO and SA reduced the leukocyte migration into the SAP, and the cytokines tumor necrosis factor and interleukin-1 (TNF-α and IL-1β, respectively) produced in the exudate. Our results are indicative that EO and SA present peripheral and central antinociceptive and anti-inflammatory effects. |
format | Online Article Text |
id | pubmed-7277703 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-72777032020-06-12 Aristolochia trilobata: Identification of the Anti-Inflammatory and Antinociceptive Effects Salomé, Dayana da Costa Cordeiro, Natália de Morais Valério, Tayná Sequeira Santos, Darlisson de Alexandria Alves, Péricles Barreto Alviano, Celuta Sales Moreno, Daniela Sales Alviano Fernandes, Patricia Dias Biomedicines Article Aristolochia trilobata, popularly known as “mil-homens,” is widely used for treatment of stomach aches, colic, asthma, pulmonary diseases, diabetes, and skin affection. We evaluated the antinociceptive and anti-inflammatory activities of the essential oil (EO) and the main constituent, 6-methyl-5-hepten-2-yl acetate (sulcatyl acetate, SA). EO and SA (1, 10, and 100 mg/kg, p.o.) were evaluated using chemical (formalin-induced licking) and thermal (hot-plate) models of nociception or inflammation (carrageenan-induced cell migration into the subcutaneous air pouch, SAP). The mechanism of antinociceptive activity was evaluated using opioid, cholinergic receptor antagonists (naloxone and atropine), or nitric oxide synthase inhibitor (L-NAME). EO and SA presented a central antinociceptive effect (the hot-plate model). In formalin-induced licking response, higher doses of EO and SA also reduced 1st and 2nd phases. None of the antagonists and enzyme inhibitor reversed antinociceptive effects. EO and SA reduced the leukocyte migration into the SAP, and the cytokines tumor necrosis factor and interleukin-1 (TNF-α and IL-1β, respectively) produced in the exudate. Our results are indicative that EO and SA present peripheral and central antinociceptive and anti-inflammatory effects. MDPI 2020-05-06 /pmc/articles/PMC7277703/ /pubmed/32384613 http://dx.doi.org/10.3390/biomedicines8050111 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Salomé, Dayana da Costa Cordeiro, Natália de Morais Valério, Tayná Sequeira Santos, Darlisson de Alexandria Alves, Péricles Barreto Alviano, Celuta Sales Moreno, Daniela Sales Alviano Fernandes, Patricia Dias Aristolochia trilobata: Identification of the Anti-Inflammatory and Antinociceptive Effects |
title | Aristolochia trilobata: Identification of the Anti-Inflammatory and Antinociceptive Effects |
title_full | Aristolochia trilobata: Identification of the Anti-Inflammatory and Antinociceptive Effects |
title_fullStr | Aristolochia trilobata: Identification of the Anti-Inflammatory and Antinociceptive Effects |
title_full_unstemmed | Aristolochia trilobata: Identification of the Anti-Inflammatory and Antinociceptive Effects |
title_short | Aristolochia trilobata: Identification of the Anti-Inflammatory and Antinociceptive Effects |
title_sort | aristolochia trilobata: identification of the anti-inflammatory and antinociceptive effects |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7277703/ https://www.ncbi.nlm.nih.gov/pubmed/32384613 http://dx.doi.org/10.3390/biomedicines8050111 |
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