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Aristolochia trilobata: Identification of the Anti-Inflammatory and Antinociceptive Effects

Aristolochia trilobata, popularly known as “mil-homens,” is widely used for treatment of stomach aches, colic, asthma, pulmonary diseases, diabetes, and skin affection. We evaluated the antinociceptive and anti-inflammatory activities of the essential oil (EO) and the main constituent, 6-methyl-5-he...

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Autores principales: Salomé, Dayana da Costa, Cordeiro, Natália de Morais, Valério, Tayná Sequeira, Santos, Darlisson de Alexandria, Alves, Péricles Barreto, Alviano, Celuta Sales, Moreno, Daniela Sales Alviano, Fernandes, Patricia Dias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7277703/
https://www.ncbi.nlm.nih.gov/pubmed/32384613
http://dx.doi.org/10.3390/biomedicines8050111
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author Salomé, Dayana da Costa
Cordeiro, Natália de Morais
Valério, Tayná Sequeira
Santos, Darlisson de Alexandria
Alves, Péricles Barreto
Alviano, Celuta Sales
Moreno, Daniela Sales Alviano
Fernandes, Patricia Dias
author_facet Salomé, Dayana da Costa
Cordeiro, Natália de Morais
Valério, Tayná Sequeira
Santos, Darlisson de Alexandria
Alves, Péricles Barreto
Alviano, Celuta Sales
Moreno, Daniela Sales Alviano
Fernandes, Patricia Dias
author_sort Salomé, Dayana da Costa
collection PubMed
description Aristolochia trilobata, popularly known as “mil-homens,” is widely used for treatment of stomach aches, colic, asthma, pulmonary diseases, diabetes, and skin affection. We evaluated the antinociceptive and anti-inflammatory activities of the essential oil (EO) and the main constituent, 6-methyl-5-hepten-2-yl acetate (sulcatyl acetate, SA). EO and SA (1, 10, and 100 mg/kg, p.o.) were evaluated using chemical (formalin-induced licking) and thermal (hot-plate) models of nociception or inflammation (carrageenan-induced cell migration into the subcutaneous air pouch, SAP). The mechanism of antinociceptive activity was evaluated using opioid, cholinergic receptor antagonists (naloxone and atropine), or nitric oxide synthase inhibitor (L-NAME). EO and SA presented a central antinociceptive effect (the hot-plate model). In formalin-induced licking response, higher doses of EO and SA also reduced 1st and 2nd phases. None of the antagonists and enzyme inhibitor reversed antinociceptive effects. EO and SA reduced the leukocyte migration into the SAP, and the cytokines tumor necrosis factor and interleukin-1 (TNF-α and IL-1β, respectively) produced in the exudate. Our results are indicative that EO and SA present peripheral and central antinociceptive and anti-inflammatory effects.
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spelling pubmed-72777032020-06-12 Aristolochia trilobata: Identification of the Anti-Inflammatory and Antinociceptive Effects Salomé, Dayana da Costa Cordeiro, Natália de Morais Valério, Tayná Sequeira Santos, Darlisson de Alexandria Alves, Péricles Barreto Alviano, Celuta Sales Moreno, Daniela Sales Alviano Fernandes, Patricia Dias Biomedicines Article Aristolochia trilobata, popularly known as “mil-homens,” is widely used for treatment of stomach aches, colic, asthma, pulmonary diseases, diabetes, and skin affection. We evaluated the antinociceptive and anti-inflammatory activities of the essential oil (EO) and the main constituent, 6-methyl-5-hepten-2-yl acetate (sulcatyl acetate, SA). EO and SA (1, 10, and 100 mg/kg, p.o.) were evaluated using chemical (formalin-induced licking) and thermal (hot-plate) models of nociception or inflammation (carrageenan-induced cell migration into the subcutaneous air pouch, SAP). The mechanism of antinociceptive activity was evaluated using opioid, cholinergic receptor antagonists (naloxone and atropine), or nitric oxide synthase inhibitor (L-NAME). EO and SA presented a central antinociceptive effect (the hot-plate model). In formalin-induced licking response, higher doses of EO and SA also reduced 1st and 2nd phases. None of the antagonists and enzyme inhibitor reversed antinociceptive effects. EO and SA reduced the leukocyte migration into the SAP, and the cytokines tumor necrosis factor and interleukin-1 (TNF-α and IL-1β, respectively) produced in the exudate. Our results are indicative that EO and SA present peripheral and central antinociceptive and anti-inflammatory effects. MDPI 2020-05-06 /pmc/articles/PMC7277703/ /pubmed/32384613 http://dx.doi.org/10.3390/biomedicines8050111 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Salomé, Dayana da Costa
Cordeiro, Natália de Morais
Valério, Tayná Sequeira
Santos, Darlisson de Alexandria
Alves, Péricles Barreto
Alviano, Celuta Sales
Moreno, Daniela Sales Alviano
Fernandes, Patricia Dias
Aristolochia trilobata: Identification of the Anti-Inflammatory and Antinociceptive Effects
title Aristolochia trilobata: Identification of the Anti-Inflammatory and Antinociceptive Effects
title_full Aristolochia trilobata: Identification of the Anti-Inflammatory and Antinociceptive Effects
title_fullStr Aristolochia trilobata: Identification of the Anti-Inflammatory and Antinociceptive Effects
title_full_unstemmed Aristolochia trilobata: Identification of the Anti-Inflammatory and Antinociceptive Effects
title_short Aristolochia trilobata: Identification of the Anti-Inflammatory and Antinociceptive Effects
title_sort aristolochia trilobata: identification of the anti-inflammatory and antinociceptive effects
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7277703/
https://www.ncbi.nlm.nih.gov/pubmed/32384613
http://dx.doi.org/10.3390/biomedicines8050111
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