Efficaciousness of Low Affinity Compared to High Affinity TSPO Ligands in the Inhibition of Hypoxic Mitochondrial Cellular Damage Induced by Cobalt Chloride in Human Lung H1299 Cells

The 18 kDa translocator protein (TSPO) plays an important role in apoptotic cell death, including apoptosis induced by the hypoxia mimicking agent cobalt chloride (CoCl(2)). In this study, the protective effects of a high (CB86; Ki = 1.6 nM) and a low (CB204; Ki = 117.7 nM) affinity TSPO ligands wer...

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Detalles Bibliográficos
Autores principales: Zeineh, Nidal, Denora, Nunzio, Laquintana, Valentino, Franco, Massimo, Weizman, Abraham, Gavish, Moshe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7277862/
https://www.ncbi.nlm.nih.gov/pubmed/32370132
http://dx.doi.org/10.3390/biomedicines8050106

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7277862/
https://www.ncbi.nlm.nih.gov/pubmed/32370132
http://dx.doi.org/10.3390/biomedicines8050106

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