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Inflammatory and Oxidative Stress Markers—Mirror Tools in Rheumatoid Arthritis

Rheumatoid arthritis (RA) is a chronic progressive autoimmune disease, associated with significant morbidity, mainly due to progressive damage and consequent disability. Oxidative stress is an important part of RA pathophysiology, as in autoimmune disease the interaction between immune response and...

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Autores principales: Mititelu, Radu Răzvan, Pădureanu, Rodica, Băcănoiu, Manuela, Pădureanu, Vlad, Docea, Anca Oana, Calina, Daniela, Barbulescu, Andreea Lili, Buga, Ana Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7277871/
https://www.ncbi.nlm.nih.gov/pubmed/32429264
http://dx.doi.org/10.3390/biomedicines8050125
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author Mititelu, Radu Răzvan
Pădureanu, Rodica
Băcănoiu, Manuela
Pădureanu, Vlad
Docea, Anca Oana
Calina, Daniela
Barbulescu, Andreea Lili
Buga, Ana Maria
author_facet Mititelu, Radu Răzvan
Pădureanu, Rodica
Băcănoiu, Manuela
Pădureanu, Vlad
Docea, Anca Oana
Calina, Daniela
Barbulescu, Andreea Lili
Buga, Ana Maria
author_sort Mititelu, Radu Răzvan
collection PubMed
description Rheumatoid arthritis (RA) is a chronic progressive autoimmune disease, associated with significant morbidity, mainly due to progressive damage and consequent disability. Oxidative stress is an important part of RA pathophysiology, as in autoimmune disease the interaction between immune response and endogenous/exogenous antigens subsequently induce the production of reactive oxygen species. The oxidative stress process seems to be positively strongly correlated with inflammation and accelerated joint destruction. We were asking ourselves if the oxidative stress biomarkers are the mirror tools of disease activity, outcome, and inflammation level in a group of RA patients under standard or biological therapy compared to healthy age-matched controls. In order to do this, the oxidative stress damage biomarkers (lipids peroxide and protein carbonyl level), antioxidant defense capacity, and pro-inflammatory status of plasma were quantified. In this study, we took into account the complete picture of RA diseases and assessed, for the first time, the inflammatory level in correlation with the oxidative stress level and antioxidant capacity of RA patients. Our results revealed that protein oxidation through carbonylation is significantly increased in RA groups compared to controls, and both protein carbonyl Pcarb and thiobarbituric acid reactive substance (TBARS) are reliable markers of ROS damage. Therefore, it is unanimous that neutrophil/lymphocyte ratio (NLR), monocyte/lymphocyte ratio (MLR), platelet/lymphocyte ratio (PltLR) correlated with Pcarb, and TBARS can provide a view of the complex phenomenon represented by proteins/lipids damage, key contributors to disease outcome, and an increased awareness should be attributed to these biomarkers.
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spelling pubmed-72778712020-06-12 Inflammatory and Oxidative Stress Markers—Mirror Tools in Rheumatoid Arthritis Mititelu, Radu Răzvan Pădureanu, Rodica Băcănoiu, Manuela Pădureanu, Vlad Docea, Anca Oana Calina, Daniela Barbulescu, Andreea Lili Buga, Ana Maria Biomedicines Article Rheumatoid arthritis (RA) is a chronic progressive autoimmune disease, associated with significant morbidity, mainly due to progressive damage and consequent disability. Oxidative stress is an important part of RA pathophysiology, as in autoimmune disease the interaction between immune response and endogenous/exogenous antigens subsequently induce the production of reactive oxygen species. The oxidative stress process seems to be positively strongly correlated with inflammation and accelerated joint destruction. We were asking ourselves if the oxidative stress biomarkers are the mirror tools of disease activity, outcome, and inflammation level in a group of RA patients under standard or biological therapy compared to healthy age-matched controls. In order to do this, the oxidative stress damage biomarkers (lipids peroxide and protein carbonyl level), antioxidant defense capacity, and pro-inflammatory status of plasma were quantified. In this study, we took into account the complete picture of RA diseases and assessed, for the first time, the inflammatory level in correlation with the oxidative stress level and antioxidant capacity of RA patients. Our results revealed that protein oxidation through carbonylation is significantly increased in RA groups compared to controls, and both protein carbonyl Pcarb and thiobarbituric acid reactive substance (TBARS) are reliable markers of ROS damage. Therefore, it is unanimous that neutrophil/lymphocyte ratio (NLR), monocyte/lymphocyte ratio (MLR), platelet/lymphocyte ratio (PltLR) correlated with Pcarb, and TBARS can provide a view of the complex phenomenon represented by proteins/lipids damage, key contributors to disease outcome, and an increased awareness should be attributed to these biomarkers. MDPI 2020-05-15 /pmc/articles/PMC7277871/ /pubmed/32429264 http://dx.doi.org/10.3390/biomedicines8050125 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Mititelu, Radu Răzvan
Pădureanu, Rodica
Băcănoiu, Manuela
Pădureanu, Vlad
Docea, Anca Oana
Calina, Daniela
Barbulescu, Andreea Lili
Buga, Ana Maria
Inflammatory and Oxidative Stress Markers—Mirror Tools in Rheumatoid Arthritis
title Inflammatory and Oxidative Stress Markers—Mirror Tools in Rheumatoid Arthritis
title_full Inflammatory and Oxidative Stress Markers—Mirror Tools in Rheumatoid Arthritis
title_fullStr Inflammatory and Oxidative Stress Markers—Mirror Tools in Rheumatoid Arthritis
title_full_unstemmed Inflammatory and Oxidative Stress Markers—Mirror Tools in Rheumatoid Arthritis
title_short Inflammatory and Oxidative Stress Markers—Mirror Tools in Rheumatoid Arthritis
title_sort inflammatory and oxidative stress markers—mirror tools in rheumatoid arthritis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7277871/
https://www.ncbi.nlm.nih.gov/pubmed/32429264
http://dx.doi.org/10.3390/biomedicines8050125
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