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Bisphenols and Oxidative Stress Biomarkers—Associations Found in Human Studies, Evaluation of Methods Used, and Strengths and Weaknesses of the Biomarkers

Bisphenols, particularly bisphenol A (4,4′-(hexafluoroisopropylidene)-diphenol) (BPA), are suspected of inducing oxidative stress in humans, which may be associated with adverse health outcomes. We investigated the associations between exposure to bisphenols and biomarkers of oxidative stress in hum...

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Autores principales: Steffensen, Inger-Lise, Dirven, Hubert, Couderq, Stephan, David, Arthur, D’Cruz, Shereen Cynthia, Fernández, Mariana F, Mustieles, Vicente, Rodríguez-Carillo, Andrea, Hofer, Tim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7277872/
https://www.ncbi.nlm.nih.gov/pubmed/32455625
http://dx.doi.org/10.3390/ijerph17103609
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author Steffensen, Inger-Lise
Dirven, Hubert
Couderq, Stephan
David, Arthur
D’Cruz, Shereen Cynthia
Fernández, Mariana F
Mustieles, Vicente
Rodríguez-Carillo, Andrea
Hofer, Tim
author_facet Steffensen, Inger-Lise
Dirven, Hubert
Couderq, Stephan
David, Arthur
D’Cruz, Shereen Cynthia
Fernández, Mariana F
Mustieles, Vicente
Rodríguez-Carillo, Andrea
Hofer, Tim
author_sort Steffensen, Inger-Lise
collection PubMed
description Bisphenols, particularly bisphenol A (4,4′-(hexafluoroisopropylidene)-diphenol) (BPA), are suspected of inducing oxidative stress in humans, which may be associated with adverse health outcomes. We investigated the associations between exposure to bisphenols and biomarkers of oxidative stress in human studies over the last 12 years (2008‒2019) related to six health endpoints and evaluated their suitability as effect biomarkers. PubMed database searches identified 27 relevant articles that were used for data extraction. In all studies, BPA exposure was reported, whereas some studies also reported other bisphenols. More than a dozen different biomarkers were measured. The most frequently measured biomarkers were 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-OHdG), 8-iso-prostaglandin F2α (8-isoprostane) and malondialdehyde (MDA), which almost always were positively associated with BPA. Methodological issues were reported for MDA, mainly the need to handle samples with caution to avoid artefact formation and its measurements using a chromatographic step to distinguish it from similar aldehydes, making some of the MDA results less reliable. Urinary 8-OHdG and 8-isoprostane can be considered the most reliable biomarkers of oxidative stress associated with BPA exposure. Although none of the biomarkers are considered BPA- or organ-specific, the biomarkers can be assessed repeatedly and non-invasively in urine and could help to understand causal relationships.
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spelling pubmed-72778722020-06-12 Bisphenols and Oxidative Stress Biomarkers—Associations Found in Human Studies, Evaluation of Methods Used, and Strengths and Weaknesses of the Biomarkers Steffensen, Inger-Lise Dirven, Hubert Couderq, Stephan David, Arthur D’Cruz, Shereen Cynthia Fernández, Mariana F Mustieles, Vicente Rodríguez-Carillo, Andrea Hofer, Tim Int J Environ Res Public Health Review Bisphenols, particularly bisphenol A (4,4′-(hexafluoroisopropylidene)-diphenol) (BPA), are suspected of inducing oxidative stress in humans, which may be associated with adverse health outcomes. We investigated the associations between exposure to bisphenols and biomarkers of oxidative stress in human studies over the last 12 years (2008‒2019) related to six health endpoints and evaluated their suitability as effect biomarkers. PubMed database searches identified 27 relevant articles that were used for data extraction. In all studies, BPA exposure was reported, whereas some studies also reported other bisphenols. More than a dozen different biomarkers were measured. The most frequently measured biomarkers were 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-OHdG), 8-iso-prostaglandin F2α (8-isoprostane) and malondialdehyde (MDA), which almost always were positively associated with BPA. Methodological issues were reported for MDA, mainly the need to handle samples with caution to avoid artefact formation and its measurements using a chromatographic step to distinguish it from similar aldehydes, making some of the MDA results less reliable. Urinary 8-OHdG and 8-isoprostane can be considered the most reliable biomarkers of oxidative stress associated with BPA exposure. Although none of the biomarkers are considered BPA- or organ-specific, the biomarkers can be assessed repeatedly and non-invasively in urine and could help to understand causal relationships. MDPI 2020-05-21 2020-05 /pmc/articles/PMC7277872/ /pubmed/32455625 http://dx.doi.org/10.3390/ijerph17103609 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Steffensen, Inger-Lise
Dirven, Hubert
Couderq, Stephan
David, Arthur
D’Cruz, Shereen Cynthia
Fernández, Mariana F
Mustieles, Vicente
Rodríguez-Carillo, Andrea
Hofer, Tim
Bisphenols and Oxidative Stress Biomarkers—Associations Found in Human Studies, Evaluation of Methods Used, and Strengths and Weaknesses of the Biomarkers
title Bisphenols and Oxidative Stress Biomarkers—Associations Found in Human Studies, Evaluation of Methods Used, and Strengths and Weaknesses of the Biomarkers
title_full Bisphenols and Oxidative Stress Biomarkers—Associations Found in Human Studies, Evaluation of Methods Used, and Strengths and Weaknesses of the Biomarkers
title_fullStr Bisphenols and Oxidative Stress Biomarkers—Associations Found in Human Studies, Evaluation of Methods Used, and Strengths and Weaknesses of the Biomarkers
title_full_unstemmed Bisphenols and Oxidative Stress Biomarkers—Associations Found in Human Studies, Evaluation of Methods Used, and Strengths and Weaknesses of the Biomarkers
title_short Bisphenols and Oxidative Stress Biomarkers—Associations Found in Human Studies, Evaluation of Methods Used, and Strengths and Weaknesses of the Biomarkers
title_sort bisphenols and oxidative stress biomarkers—associations found in human studies, evaluation of methods used, and strengths and weaknesses of the biomarkers
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7277872/
https://www.ncbi.nlm.nih.gov/pubmed/32455625
http://dx.doi.org/10.3390/ijerph17103609
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