Genetic Variants in the 3’UTR of BRCA1 and BRCA2 Genes and Their Putative Effects on the microRNA Mechanism in Hereditary Breast and Ovarian Cancer

Hereditary breast and ovarian cancer (HBOC) syndrome is mainly caused by mutations in the BRCA1 and BRCA2 genes. The 3’UTR region allows for the binding of microRNAs, which are involved in genetic tune regulation. We aimed to identify allelic variants on 3’UTR miRNA-binding sites in the BRCA1 and BR...

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Detalles Bibliográficos
Autores principales: Sánchez-Chaparro, María Marisela, Garza-Veloz, Idalia, Zayas-Villanueva, Omar Alejandro, Martinez-Fierro, Margarita L., Delgado-Enciso, Iván, Gomez-Govea, Mayra Alejandra, Martínez-de-Villarreal, Laura Elia, Reséndez-Pérez, Diana, Rodríguez-Sánchez, Iram Pablo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7277914/
https://www.ncbi.nlm.nih.gov/pubmed/32414209
http://dx.doi.org/10.3390/diagnostics10050298

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