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Plasma Zinc Levels in Males with Androgenetic Alopecia as Possible Predictors of the Subsequent Conservative Therapy’s Effectiveness

Androgenic alopecia (AGA) is the most common type of progressive hair loss in man. The search for reliable predictors of the conservative treatment’s effectiveness is an urgent problem today. Forty-eight patients with AGA, stages I–IV by the Norwood–Hamilton scale, were treated for 4 months with 5%...

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Autores principales: Kondrakhina, Irina N., Verbenko, Dmitry A., Zatevalov, Alexander M., Gatiatulina, Eugenia R., Nikonorov, Alexandr A., Deryabin, Dmitrij G., Kubanov, Alexey A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7277952/
https://www.ncbi.nlm.nih.gov/pubmed/32456296
http://dx.doi.org/10.3390/diagnostics10050336
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author Kondrakhina, Irina N.
Verbenko, Dmitry A.
Zatevalov, Alexander M.
Gatiatulina, Eugenia R.
Nikonorov, Alexandr A.
Deryabin, Dmitrij G.
Kubanov, Alexey A.
author_facet Kondrakhina, Irina N.
Verbenko, Dmitry A.
Zatevalov, Alexander M.
Gatiatulina, Eugenia R.
Nikonorov, Alexandr A.
Deryabin, Dmitrij G.
Kubanov, Alexey A.
author_sort Kondrakhina, Irina N.
collection PubMed
description Androgenic alopecia (AGA) is the most common type of progressive hair loss in man. The search for reliable predictors of the conservative treatment’s effectiveness is an urgent problem today. Forty-eight patients with AGA, stages I–IV by the Norwood–Hamilton scale, were treated for 4 months with 5% topical minoxidil joints with corrections for trace element and vitamin imbalances. In most cases, the positive therapy’s effect was shown in the parietal but not in the occipital area, whereas that effect was observed in others. The attempts to associate the therapy’s effectiveness with initially defined genetic, hormonal, and metabolic parameters showed the absence of differences between groups with positive and negative outcomes. Among the studied nutrient parameters (Zn, Cu, Mg, Ca, Fe, and Se, as well as vitamins B12, E, D, and folic acid), differences between these groups was shown in zinc content only. The starting point from a zinc plasma level above 10 µmol/L likely provides the success of the subsequent conservative therapy and correlates with an increase in the hair density and diameter in the parietal area. The integral predictive value of the Zn plasma level was assessed as 72.3% (positive predictive value: −88%; and negative predictive value: −55%).
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spelling pubmed-72779522020-06-12 Plasma Zinc Levels in Males with Androgenetic Alopecia as Possible Predictors of the Subsequent Conservative Therapy’s Effectiveness Kondrakhina, Irina N. Verbenko, Dmitry A. Zatevalov, Alexander M. Gatiatulina, Eugenia R. Nikonorov, Alexandr A. Deryabin, Dmitrij G. Kubanov, Alexey A. Diagnostics (Basel) Article Androgenic alopecia (AGA) is the most common type of progressive hair loss in man. The search for reliable predictors of the conservative treatment’s effectiveness is an urgent problem today. Forty-eight patients with AGA, stages I–IV by the Norwood–Hamilton scale, were treated for 4 months with 5% topical minoxidil joints with corrections for trace element and vitamin imbalances. In most cases, the positive therapy’s effect was shown in the parietal but not in the occipital area, whereas that effect was observed in others. The attempts to associate the therapy’s effectiveness with initially defined genetic, hormonal, and metabolic parameters showed the absence of differences between groups with positive and negative outcomes. Among the studied nutrient parameters (Zn, Cu, Mg, Ca, Fe, and Se, as well as vitamins B12, E, D, and folic acid), differences between these groups was shown in zinc content only. The starting point from a zinc plasma level above 10 µmol/L likely provides the success of the subsequent conservative therapy and correlates with an increase in the hair density and diameter in the parietal area. The integral predictive value of the Zn plasma level was assessed as 72.3% (positive predictive value: −88%; and negative predictive value: −55%). MDPI 2020-05-24 /pmc/articles/PMC7277952/ /pubmed/32456296 http://dx.doi.org/10.3390/diagnostics10050336 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kondrakhina, Irina N.
Verbenko, Dmitry A.
Zatevalov, Alexander M.
Gatiatulina, Eugenia R.
Nikonorov, Alexandr A.
Deryabin, Dmitrij G.
Kubanov, Alexey A.
Plasma Zinc Levels in Males with Androgenetic Alopecia as Possible Predictors of the Subsequent Conservative Therapy’s Effectiveness
title Plasma Zinc Levels in Males with Androgenetic Alopecia as Possible Predictors of the Subsequent Conservative Therapy’s Effectiveness
title_full Plasma Zinc Levels in Males with Androgenetic Alopecia as Possible Predictors of the Subsequent Conservative Therapy’s Effectiveness
title_fullStr Plasma Zinc Levels in Males with Androgenetic Alopecia as Possible Predictors of the Subsequent Conservative Therapy’s Effectiveness
title_full_unstemmed Plasma Zinc Levels in Males with Androgenetic Alopecia as Possible Predictors of the Subsequent Conservative Therapy’s Effectiveness
title_short Plasma Zinc Levels in Males with Androgenetic Alopecia as Possible Predictors of the Subsequent Conservative Therapy’s Effectiveness
title_sort plasma zinc levels in males with androgenetic alopecia as possible predictors of the subsequent conservative therapy’s effectiveness
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7277952/
https://www.ncbi.nlm.nih.gov/pubmed/32456296
http://dx.doi.org/10.3390/diagnostics10050336
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