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Diagnostic Value of Imaging Methods in the Histological Four Grading of Hepatocellular Carcinoma
We attempted to establish an ultrasound (US) imaging-diagnostic system for histopathological grades of differentiation of hepatocellular carcinoma (HCC). We conducted a retrospective study of histopathologically confirmed 200 HCCs, classified as early (45 lesions), well- (31 lesions), moderately (68...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7277955/ https://www.ncbi.nlm.nih.gov/pubmed/32438701 http://dx.doi.org/10.3390/diagnostics10050321 |
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author | Wang, Feiqian Numata, Kazushi Nakano, Masayuki Tanabe, Mikiko Chuma, Makoto Nihonmatsu, Hiromi Nozaki, Akito Ogushi, Katsuaki Luo, Wen Ruan, Litao Okada, Masahiro Otani, Masako Inayama, Yoshiaki Maeda, Shin |
author_facet | Wang, Feiqian Numata, Kazushi Nakano, Masayuki Tanabe, Mikiko Chuma, Makoto Nihonmatsu, Hiromi Nozaki, Akito Ogushi, Katsuaki Luo, Wen Ruan, Litao Okada, Masahiro Otani, Masako Inayama, Yoshiaki Maeda, Shin |
author_sort | Wang, Feiqian |
collection | PubMed |
description | We attempted to establish an ultrasound (US) imaging-diagnostic system for histopathological grades of differentiation of hepatocellular carcinoma (HCC). We conducted a retrospective study of histopathologically confirmed 200 HCCs, classified as early (45 lesions), well- (31 lesions), moderately (68 lesions) or poorly differentiated (diff.) (56 lesions) HCCs. We performed grayscale US to estimate the presence/absence of halo and mosaic signs, Sonazoid contrast-enhanced US (CEUS) to determine vascularity (hypo/iso/hyper) of lesion in arterial and portal phase (PP), and echogenicity of lesion in post-vascular phase (PVP). All findings were of significance for the diagnosis of some (but not all) histological grades (p < 0.001–0.05). Combined findings with a relatively high diagnostic efficacy for early, poorly and moderately diff. HCC were a combination of absence of halo sign and isoechogenicity in PVP of CEUS (accuracy: 93.0%, AUC: 0.908), hypovascularity in PP (accuracy: 78.0%, area under the curve (AUC): 0.750), and a combination of isovascularity in PP and hypoechogenicity in PVP (accuracy: 75.0%, AUC: 0.739), respectively. On the other hand, neither any individual finding nor any combination of findings yielded an AUC of over 0.657 for the diagnosis of well-diff. HCC. Our study provides encouraging data on Sonazoid CEUS in the histological differential diagnosis of HCC, especially in early HCC, and the effectiveness of this imaging method should be further proved by prospective, large sample, multicenter studies. |
format | Online Article Text |
id | pubmed-7277955 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-72779552020-06-12 Diagnostic Value of Imaging Methods in the Histological Four Grading of Hepatocellular Carcinoma Wang, Feiqian Numata, Kazushi Nakano, Masayuki Tanabe, Mikiko Chuma, Makoto Nihonmatsu, Hiromi Nozaki, Akito Ogushi, Katsuaki Luo, Wen Ruan, Litao Okada, Masahiro Otani, Masako Inayama, Yoshiaki Maeda, Shin Diagnostics (Basel) Article We attempted to establish an ultrasound (US) imaging-diagnostic system for histopathological grades of differentiation of hepatocellular carcinoma (HCC). We conducted a retrospective study of histopathologically confirmed 200 HCCs, classified as early (45 lesions), well- (31 lesions), moderately (68 lesions) or poorly differentiated (diff.) (56 lesions) HCCs. We performed grayscale US to estimate the presence/absence of halo and mosaic signs, Sonazoid contrast-enhanced US (CEUS) to determine vascularity (hypo/iso/hyper) of lesion in arterial and portal phase (PP), and echogenicity of lesion in post-vascular phase (PVP). All findings were of significance for the diagnosis of some (but not all) histological grades (p < 0.001–0.05). Combined findings with a relatively high diagnostic efficacy for early, poorly and moderately diff. HCC were a combination of absence of halo sign and isoechogenicity in PVP of CEUS (accuracy: 93.0%, AUC: 0.908), hypovascularity in PP (accuracy: 78.0%, area under the curve (AUC): 0.750), and a combination of isovascularity in PP and hypoechogenicity in PVP (accuracy: 75.0%, AUC: 0.739), respectively. On the other hand, neither any individual finding nor any combination of findings yielded an AUC of over 0.657 for the diagnosis of well-diff. HCC. Our study provides encouraging data on Sonazoid CEUS in the histological differential diagnosis of HCC, especially in early HCC, and the effectiveness of this imaging method should be further proved by prospective, large sample, multicenter studies. MDPI 2020-05-19 /pmc/articles/PMC7277955/ /pubmed/32438701 http://dx.doi.org/10.3390/diagnostics10050321 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Wang, Feiqian Numata, Kazushi Nakano, Masayuki Tanabe, Mikiko Chuma, Makoto Nihonmatsu, Hiromi Nozaki, Akito Ogushi, Katsuaki Luo, Wen Ruan, Litao Okada, Masahiro Otani, Masako Inayama, Yoshiaki Maeda, Shin Diagnostic Value of Imaging Methods in the Histological Four Grading of Hepatocellular Carcinoma |
title | Diagnostic Value of Imaging Methods in the Histological Four Grading of Hepatocellular Carcinoma |
title_full | Diagnostic Value of Imaging Methods in the Histological Four Grading of Hepatocellular Carcinoma |
title_fullStr | Diagnostic Value of Imaging Methods in the Histological Four Grading of Hepatocellular Carcinoma |
title_full_unstemmed | Diagnostic Value of Imaging Methods in the Histological Four Grading of Hepatocellular Carcinoma |
title_short | Diagnostic Value of Imaging Methods in the Histological Four Grading of Hepatocellular Carcinoma |
title_sort | diagnostic value of imaging methods in the histological four grading of hepatocellular carcinoma |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7277955/ https://www.ncbi.nlm.nih.gov/pubmed/32438701 http://dx.doi.org/10.3390/diagnostics10050321 |
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