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Diagnostic Value of Imaging Methods in the Histological Four Grading of Hepatocellular Carcinoma

We attempted to establish an ultrasound (US) imaging-diagnostic system for histopathological grades of differentiation of hepatocellular carcinoma (HCC). We conducted a retrospective study of histopathologically confirmed 200 HCCs, classified as early (45 lesions), well- (31 lesions), moderately (68...

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Autores principales: Wang, Feiqian, Numata, Kazushi, Nakano, Masayuki, Tanabe, Mikiko, Chuma, Makoto, Nihonmatsu, Hiromi, Nozaki, Akito, Ogushi, Katsuaki, Luo, Wen, Ruan, Litao, Okada, Masahiro, Otani, Masako, Inayama, Yoshiaki, Maeda, Shin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7277955/
https://www.ncbi.nlm.nih.gov/pubmed/32438701
http://dx.doi.org/10.3390/diagnostics10050321
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author Wang, Feiqian
Numata, Kazushi
Nakano, Masayuki
Tanabe, Mikiko
Chuma, Makoto
Nihonmatsu, Hiromi
Nozaki, Akito
Ogushi, Katsuaki
Luo, Wen
Ruan, Litao
Okada, Masahiro
Otani, Masako
Inayama, Yoshiaki
Maeda, Shin
author_facet Wang, Feiqian
Numata, Kazushi
Nakano, Masayuki
Tanabe, Mikiko
Chuma, Makoto
Nihonmatsu, Hiromi
Nozaki, Akito
Ogushi, Katsuaki
Luo, Wen
Ruan, Litao
Okada, Masahiro
Otani, Masako
Inayama, Yoshiaki
Maeda, Shin
author_sort Wang, Feiqian
collection PubMed
description We attempted to establish an ultrasound (US) imaging-diagnostic system for histopathological grades of differentiation of hepatocellular carcinoma (HCC). We conducted a retrospective study of histopathologically confirmed 200 HCCs, classified as early (45 lesions), well- (31 lesions), moderately (68 lesions) or poorly differentiated (diff.) (56 lesions) HCCs. We performed grayscale US to estimate the presence/absence of halo and mosaic signs, Sonazoid contrast-enhanced US (CEUS) to determine vascularity (hypo/iso/hyper) of lesion in arterial and portal phase (PP), and echogenicity of lesion in post-vascular phase (PVP). All findings were of significance for the diagnosis of some (but not all) histological grades (p < 0.001–0.05). Combined findings with a relatively high diagnostic efficacy for early, poorly and moderately diff. HCC were a combination of absence of halo sign and isoechogenicity in PVP of CEUS (accuracy: 93.0%, AUC: 0.908), hypovascularity in PP (accuracy: 78.0%, area under the curve (AUC): 0.750), and a combination of isovascularity in PP and hypoechogenicity in PVP (accuracy: 75.0%, AUC: 0.739), respectively. On the other hand, neither any individual finding nor any combination of findings yielded an AUC of over 0.657 for the diagnosis of well-diff. HCC. Our study provides encouraging data on Sonazoid CEUS in the histological differential diagnosis of HCC, especially in early HCC, and the effectiveness of this imaging method should be further proved by prospective, large sample, multicenter studies.
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spelling pubmed-72779552020-06-12 Diagnostic Value of Imaging Methods in the Histological Four Grading of Hepatocellular Carcinoma Wang, Feiqian Numata, Kazushi Nakano, Masayuki Tanabe, Mikiko Chuma, Makoto Nihonmatsu, Hiromi Nozaki, Akito Ogushi, Katsuaki Luo, Wen Ruan, Litao Okada, Masahiro Otani, Masako Inayama, Yoshiaki Maeda, Shin Diagnostics (Basel) Article We attempted to establish an ultrasound (US) imaging-diagnostic system for histopathological grades of differentiation of hepatocellular carcinoma (HCC). We conducted a retrospective study of histopathologically confirmed 200 HCCs, classified as early (45 lesions), well- (31 lesions), moderately (68 lesions) or poorly differentiated (diff.) (56 lesions) HCCs. We performed grayscale US to estimate the presence/absence of halo and mosaic signs, Sonazoid contrast-enhanced US (CEUS) to determine vascularity (hypo/iso/hyper) of lesion in arterial and portal phase (PP), and echogenicity of lesion in post-vascular phase (PVP). All findings were of significance for the diagnosis of some (but not all) histological grades (p < 0.001–0.05). Combined findings with a relatively high diagnostic efficacy for early, poorly and moderately diff. HCC were a combination of absence of halo sign and isoechogenicity in PVP of CEUS (accuracy: 93.0%, AUC: 0.908), hypovascularity in PP (accuracy: 78.0%, area under the curve (AUC): 0.750), and a combination of isovascularity in PP and hypoechogenicity in PVP (accuracy: 75.0%, AUC: 0.739), respectively. On the other hand, neither any individual finding nor any combination of findings yielded an AUC of over 0.657 for the diagnosis of well-diff. HCC. Our study provides encouraging data on Sonazoid CEUS in the histological differential diagnosis of HCC, especially in early HCC, and the effectiveness of this imaging method should be further proved by prospective, large sample, multicenter studies. MDPI 2020-05-19 /pmc/articles/PMC7277955/ /pubmed/32438701 http://dx.doi.org/10.3390/diagnostics10050321 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Wang, Feiqian
Numata, Kazushi
Nakano, Masayuki
Tanabe, Mikiko
Chuma, Makoto
Nihonmatsu, Hiromi
Nozaki, Akito
Ogushi, Katsuaki
Luo, Wen
Ruan, Litao
Okada, Masahiro
Otani, Masako
Inayama, Yoshiaki
Maeda, Shin
Diagnostic Value of Imaging Methods in the Histological Four Grading of Hepatocellular Carcinoma
title Diagnostic Value of Imaging Methods in the Histological Four Grading of Hepatocellular Carcinoma
title_full Diagnostic Value of Imaging Methods in the Histological Four Grading of Hepatocellular Carcinoma
title_fullStr Diagnostic Value of Imaging Methods in the Histological Four Grading of Hepatocellular Carcinoma
title_full_unstemmed Diagnostic Value of Imaging Methods in the Histological Four Grading of Hepatocellular Carcinoma
title_short Diagnostic Value of Imaging Methods in the Histological Four Grading of Hepatocellular Carcinoma
title_sort diagnostic value of imaging methods in the histological four grading of hepatocellular carcinoma
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7277955/
https://www.ncbi.nlm.nih.gov/pubmed/32438701
http://dx.doi.org/10.3390/diagnostics10050321
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