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Detection and Diagnosis of Breast Cancer Using Artificial Intelligence Based Assessment of Maximum Intensity Projection Dynamic Contrast-Enhanced Magnetic Resonance Images

We aimed to evaluate an artificial intelligence (AI) system that can detect and diagnose lesions of maximum intensity projection (MIP) in dynamic contrast-enhanced (DCE) breast magnetic resonance imaging (MRI). We retrospectively gathered MIPs of DCE breast MRI for training and validation data from...

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Autores principales: Adachi, Mio, Fujioka, Tomoyuki, Mori, Mio, Kubota, Kazunori, Kikuchi, Yuka, Xiaotong, Wu, Oyama, Jun, Kimura, Koichiro, Oda, Goshi, Nakagawa, Tsuyoshi, Uetake, Hiroyuki, Tateishi, Ukihide
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7277981/
https://www.ncbi.nlm.nih.gov/pubmed/32443922
http://dx.doi.org/10.3390/diagnostics10050330
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author Adachi, Mio
Fujioka, Tomoyuki
Mori, Mio
Kubota, Kazunori
Kikuchi, Yuka
Xiaotong, Wu
Oyama, Jun
Kimura, Koichiro
Oda, Goshi
Nakagawa, Tsuyoshi
Uetake, Hiroyuki
Tateishi, Ukihide
author_facet Adachi, Mio
Fujioka, Tomoyuki
Mori, Mio
Kubota, Kazunori
Kikuchi, Yuka
Xiaotong, Wu
Oyama, Jun
Kimura, Koichiro
Oda, Goshi
Nakagawa, Tsuyoshi
Uetake, Hiroyuki
Tateishi, Ukihide
author_sort Adachi, Mio
collection PubMed
description We aimed to evaluate an artificial intelligence (AI) system that can detect and diagnose lesions of maximum intensity projection (MIP) in dynamic contrast-enhanced (DCE) breast magnetic resonance imaging (MRI). We retrospectively gathered MIPs of DCE breast MRI for training and validation data from 30 and 7 normal individuals, 49 and 20 benign cases, and 135 and 45 malignant cases, respectively. Breast lesions were indicated with a bounding box and labeled as benign or malignant by a radiologist, while the AI system was trained to detect and calculate possibilities of malignancy using RetinaNet. The AI system was analyzed using test sets of 13 normal, 20 benign, and 52 malignant cases. Four human readers also scored these test data with and without the assistance of the AI system for the possibility of a malignancy in each breast. Sensitivity, specificity, and area under the receiver operating characteristic curve (AUC) were 0.926, 0.828, and 0.925 for the AI system; 0.847, 0.841, and 0.884 for human readers without AI; and 0.889, 0.823, and 0.899 for human readers with AI using a cutoff value of 2%, respectively. The AI system showed better diagnostic performance compared to the human readers (p = 0.002), and because of the increased performance of human readers with the assistance of the AI system, the AUC of human readers was significantly higher with than without the AI system (p = 0.039). Our AI system showed a high performance ability in detecting and diagnosing lesions in MIPs of DCE breast MRI and increased the diagnostic performance of human readers.
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spelling pubmed-72779812020-06-12 Detection and Diagnosis of Breast Cancer Using Artificial Intelligence Based Assessment of Maximum Intensity Projection Dynamic Contrast-Enhanced Magnetic Resonance Images Adachi, Mio Fujioka, Tomoyuki Mori, Mio Kubota, Kazunori Kikuchi, Yuka Xiaotong, Wu Oyama, Jun Kimura, Koichiro Oda, Goshi Nakagawa, Tsuyoshi Uetake, Hiroyuki Tateishi, Ukihide Diagnostics (Basel) Article We aimed to evaluate an artificial intelligence (AI) system that can detect and diagnose lesions of maximum intensity projection (MIP) in dynamic contrast-enhanced (DCE) breast magnetic resonance imaging (MRI). We retrospectively gathered MIPs of DCE breast MRI for training and validation data from 30 and 7 normal individuals, 49 and 20 benign cases, and 135 and 45 malignant cases, respectively. Breast lesions were indicated with a bounding box and labeled as benign or malignant by a radiologist, while the AI system was trained to detect and calculate possibilities of malignancy using RetinaNet. The AI system was analyzed using test sets of 13 normal, 20 benign, and 52 malignant cases. Four human readers also scored these test data with and without the assistance of the AI system for the possibility of a malignancy in each breast. Sensitivity, specificity, and area under the receiver operating characteristic curve (AUC) were 0.926, 0.828, and 0.925 for the AI system; 0.847, 0.841, and 0.884 for human readers without AI; and 0.889, 0.823, and 0.899 for human readers with AI using a cutoff value of 2%, respectively. The AI system showed better diagnostic performance compared to the human readers (p = 0.002), and because of the increased performance of human readers with the assistance of the AI system, the AUC of human readers was significantly higher with than without the AI system (p = 0.039). Our AI system showed a high performance ability in detecting and diagnosing lesions in MIPs of DCE breast MRI and increased the diagnostic performance of human readers. MDPI 2020-05-20 /pmc/articles/PMC7277981/ /pubmed/32443922 http://dx.doi.org/10.3390/diagnostics10050330 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Adachi, Mio
Fujioka, Tomoyuki
Mori, Mio
Kubota, Kazunori
Kikuchi, Yuka
Xiaotong, Wu
Oyama, Jun
Kimura, Koichiro
Oda, Goshi
Nakagawa, Tsuyoshi
Uetake, Hiroyuki
Tateishi, Ukihide
Detection and Diagnosis of Breast Cancer Using Artificial Intelligence Based Assessment of Maximum Intensity Projection Dynamic Contrast-Enhanced Magnetic Resonance Images
title Detection and Diagnosis of Breast Cancer Using Artificial Intelligence Based Assessment of Maximum Intensity Projection Dynamic Contrast-Enhanced Magnetic Resonance Images
title_full Detection and Diagnosis of Breast Cancer Using Artificial Intelligence Based Assessment of Maximum Intensity Projection Dynamic Contrast-Enhanced Magnetic Resonance Images
title_fullStr Detection and Diagnosis of Breast Cancer Using Artificial Intelligence Based Assessment of Maximum Intensity Projection Dynamic Contrast-Enhanced Magnetic Resonance Images
title_full_unstemmed Detection and Diagnosis of Breast Cancer Using Artificial Intelligence Based Assessment of Maximum Intensity Projection Dynamic Contrast-Enhanced Magnetic Resonance Images
title_short Detection and Diagnosis of Breast Cancer Using Artificial Intelligence Based Assessment of Maximum Intensity Projection Dynamic Contrast-Enhanced Magnetic Resonance Images
title_sort detection and diagnosis of breast cancer using artificial intelligence based assessment of maximum intensity projection dynamic contrast-enhanced magnetic resonance images
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7277981/
https://www.ncbi.nlm.nih.gov/pubmed/32443922
http://dx.doi.org/10.3390/diagnostics10050330
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