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Treatment of post-menopausal acne with tretinoin lotion 0.05% delivers rapid results and concomitant benefits
We describe a case of comedonal acne in a post-menopausal female treated with a novel tretinoin lotion 0.05%. The patient also had some actinic keratoses, which are hyperkeratotic, scaly lesions caused by prolonged exposure to ultraviolet radiation. These lesions have the ability to progress into sq...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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SAGE Publications
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7278291/ https://www.ncbi.nlm.nih.gov/pubmed/32551118 http://dx.doi.org/10.1177/2050313X20929798 |
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author | Sangha, Archana M |
author_facet | Sangha, Archana M |
author_sort | Sangha, Archana M |
collection | PubMed |
description | We describe a case of comedonal acne in a post-menopausal female treated with a novel tretinoin lotion 0.05%. The patient also had some actinic keratoses, which are hyperkeratotic, scaly lesions caused by prolonged exposure to ultraviolet radiation. These lesions have the ability to progress into squamous cell carcinoma. Actinic keratoses can occur in patients as young as 20 years, but are more common in patients aged 50 years and older. Topical retinoids are recommended as monotherapy in comedonal acne but despite their documented clinical efficacy are underutilized due to concerns about cutaneous tolerability. Topical tretinoin is currently not recommended as first-line therapy in the treatment of actinic keratosis as its efficacy is not comparable to that of other modalities. In this patient, a novel tretinoin lotion 0.05% resulted in rapid in and sustained improvement of acne. The investigator also observed improvement in actinic keratoses and photodamage. If these results can be confirmed in a larger patient population this may be an attractive area of investigation for the treatment of patients with adult acne and photodamaged skin. |
format | Online Article Text |
id | pubmed-7278291 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-72782912020-06-17 Treatment of post-menopausal acne with tretinoin lotion 0.05% delivers rapid results and concomitant benefits Sangha, Archana M SAGE Open Med Case Rep Case Report We describe a case of comedonal acne in a post-menopausal female treated with a novel tretinoin lotion 0.05%. The patient also had some actinic keratoses, which are hyperkeratotic, scaly lesions caused by prolonged exposure to ultraviolet radiation. These lesions have the ability to progress into squamous cell carcinoma. Actinic keratoses can occur in patients as young as 20 years, but are more common in patients aged 50 years and older. Topical retinoids are recommended as monotherapy in comedonal acne but despite their documented clinical efficacy are underutilized due to concerns about cutaneous tolerability. Topical tretinoin is currently not recommended as first-line therapy in the treatment of actinic keratosis as its efficacy is not comparable to that of other modalities. In this patient, a novel tretinoin lotion 0.05% resulted in rapid in and sustained improvement of acne. The investigator also observed improvement in actinic keratoses and photodamage. If these results can be confirmed in a larger patient population this may be an attractive area of investigation for the treatment of patients with adult acne and photodamaged skin. SAGE Publications 2020-06-07 /pmc/articles/PMC7278291/ /pubmed/32551118 http://dx.doi.org/10.1177/2050313X20929798 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Case Report Sangha, Archana M Treatment of post-menopausal acne with tretinoin lotion 0.05% delivers rapid results and concomitant benefits |
title | Treatment of post-menopausal acne with tretinoin lotion 0.05% delivers rapid results and concomitant benefits |
title_full | Treatment of post-menopausal acne with tretinoin lotion 0.05% delivers rapid results and concomitant benefits |
title_fullStr | Treatment of post-menopausal acne with tretinoin lotion 0.05% delivers rapid results and concomitant benefits |
title_full_unstemmed | Treatment of post-menopausal acne with tretinoin lotion 0.05% delivers rapid results and concomitant benefits |
title_short | Treatment of post-menopausal acne with tretinoin lotion 0.05% delivers rapid results and concomitant benefits |
title_sort | treatment of post-menopausal acne with tretinoin lotion 0.05% delivers rapid results and concomitant benefits |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7278291/ https://www.ncbi.nlm.nih.gov/pubmed/32551118 http://dx.doi.org/10.1177/2050313X20929798 |
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