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Pragmatic Markers in the Management of Asthma: A Real-World-Based Approach

Bronchial hyperreactivity, reversible airflow limitation and chronic airway inflammation characterize asthma pathophysiology. Personalized medicine, i.e., a tailored management approach, is appropriate for asthma management and is based on the identification of peculiar phenotypes and endotypes. Bio...

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Autores principales: Ciprandi, Giorgio, Marseglia, Gian Luigi, Ricciardolo, Fabio Luigi Massimo, Tosca, Maria Angela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7278574/
https://www.ncbi.nlm.nih.gov/pubmed/32443418
http://dx.doi.org/10.3390/children7050048
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author Ciprandi, Giorgio
Marseglia, Gian Luigi
Ricciardolo, Fabio Luigi Massimo
Tosca, Maria Angela
author_facet Ciprandi, Giorgio
Marseglia, Gian Luigi
Ricciardolo, Fabio Luigi Massimo
Tosca, Maria Angela
author_sort Ciprandi, Giorgio
collection PubMed
description Bronchial hyperreactivity, reversible airflow limitation and chronic airway inflammation characterize asthma pathophysiology. Personalized medicine, i.e., a tailored management approach, is appropriate for asthma management and is based on the identification of peculiar phenotypes and endotypes. Biomarkers are necessary for defining phenotypes and endotypes. Several biomarkers have been described in asthma, but most of them are experimental and/or not commonly available. The current paper will, therefore, present pragmatic biomarkers useful for asthma management that are available in daily clinical practice. In this regard, eosinophil assessment and serum allergen-specific IgE assay are the most reliable biomarkers. Lung function, mainly concerning forced expiratory flow at 25-755 of vital capacity (FEF(25-75)), and nasal cytology may be envisaged as ancillary biomarkers in asthma management. In conclusion, biomarkers have clinical relevance in asthma concerning both the endotype definition and the personalization of the therapy.
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spelling pubmed-72785742020-06-12 Pragmatic Markers in the Management of Asthma: A Real-World-Based Approach Ciprandi, Giorgio Marseglia, Gian Luigi Ricciardolo, Fabio Luigi Massimo Tosca, Maria Angela Children (Basel) Communication Bronchial hyperreactivity, reversible airflow limitation and chronic airway inflammation characterize asthma pathophysiology. Personalized medicine, i.e., a tailored management approach, is appropriate for asthma management and is based on the identification of peculiar phenotypes and endotypes. Biomarkers are necessary for defining phenotypes and endotypes. Several biomarkers have been described in asthma, but most of them are experimental and/or not commonly available. The current paper will, therefore, present pragmatic biomarkers useful for asthma management that are available in daily clinical practice. In this regard, eosinophil assessment and serum allergen-specific IgE assay are the most reliable biomarkers. Lung function, mainly concerning forced expiratory flow at 25-755 of vital capacity (FEF(25-75)), and nasal cytology may be envisaged as ancillary biomarkers in asthma management. In conclusion, biomarkers have clinical relevance in asthma concerning both the endotype definition and the personalization of the therapy. MDPI 2020-05-18 /pmc/articles/PMC7278574/ /pubmed/32443418 http://dx.doi.org/10.3390/children7050048 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Ciprandi, Giorgio
Marseglia, Gian Luigi
Ricciardolo, Fabio Luigi Massimo
Tosca, Maria Angela
Pragmatic Markers in the Management of Asthma: A Real-World-Based Approach
title Pragmatic Markers in the Management of Asthma: A Real-World-Based Approach
title_full Pragmatic Markers in the Management of Asthma: A Real-World-Based Approach
title_fullStr Pragmatic Markers in the Management of Asthma: A Real-World-Based Approach
title_full_unstemmed Pragmatic Markers in the Management of Asthma: A Real-World-Based Approach
title_short Pragmatic Markers in the Management of Asthma: A Real-World-Based Approach
title_sort pragmatic markers in the management of asthma: a real-world-based approach
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7278574/
https://www.ncbi.nlm.nih.gov/pubmed/32443418
http://dx.doi.org/10.3390/children7050048
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