Cargando…

Modeling interactions between brain function, diet adherence behaviors, and weight loss success

INTRODUCTION: Obesity is linked to altered activation in reward and control brain circuitry; however, the associated brain activity related to successful or unsuccessful weight loss (WL) is unclear. METHODS: Adults with obesity (N = 75) completed a baseline functional magnetic resonance imaging (fMR...

Descripción completa

Detalles Bibliográficos
Autores principales: Szabo‐Reed, Amanda N., Martin, Laura E., Hu, Jinxiang, Yeh, Hung‐Wen, Powell, Joshua, Lepping, Rebecca J., Patrician, Trisha M., Breslin, Florance J., Donnelly, Joseph E., Savage, Cary R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7278911/
https://www.ncbi.nlm.nih.gov/pubmed/32523717
http://dx.doi.org/10.1002/osp4.403
_version_ 1783543440448946176
author Szabo‐Reed, Amanda N.
Martin, Laura E.
Hu, Jinxiang
Yeh, Hung‐Wen
Powell, Joshua
Lepping, Rebecca J.
Patrician, Trisha M.
Breslin, Florance J.
Donnelly, Joseph E.
Savage, Cary R.
author_facet Szabo‐Reed, Amanda N.
Martin, Laura E.
Hu, Jinxiang
Yeh, Hung‐Wen
Powell, Joshua
Lepping, Rebecca J.
Patrician, Trisha M.
Breslin, Florance J.
Donnelly, Joseph E.
Savage, Cary R.
author_sort Szabo‐Reed, Amanda N.
collection PubMed
description INTRODUCTION: Obesity is linked to altered activation in reward and control brain circuitry; however, the associated brain activity related to successful or unsuccessful weight loss (WL) is unclear. METHODS: Adults with obesity (N = 75) completed a baseline functional magnetic resonance imaging (fMRI) scan before entering a WL intervention (ie,3‐month diet and physical activity [PA] program). We conducted an exploratory analysis to identify the contributions of baseline brain activation, adherence behavior patterns, and the associated connections to WL at the conclusion of a 3‐month WL intervention. Food cue‐reactivity brain regions were functionally identified using fMRI to index brain activation to food vs nonfood cues. Food consumption, PA, and class attendance were collected weekly during the 3‐month intervention. RESULTS: The left middle frontal gyrus (L‐MFG, BA 46) and right middle frontal gyrus (R‐MFG; BA 9) were positively activated when viewing food compared with nonfood images. Structural equation modeling with bootstrapping was used to investigate a hypothesized path model and revealed the following significant paths: (1) attendance to 3‐month WL, (2) R‐MFG to attendance, and (3) indirect effects of R‐MFG through attendance on WL. CONCLUSION: Findings suggest that brain activation to appetitive food cues predicts future WL through mediating session attendance, diet, and PA. This study contributes to the growing evidence of the importance of food cue reactivity and self‐regulation brain regions and their impact on WL outcomes.
format Online
Article
Text
id pubmed-7278911
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-72789112020-06-09 Modeling interactions between brain function, diet adherence behaviors, and weight loss success Szabo‐Reed, Amanda N. Martin, Laura E. Hu, Jinxiang Yeh, Hung‐Wen Powell, Joshua Lepping, Rebecca J. Patrician, Trisha M. Breslin, Florance J. Donnelly, Joseph E. Savage, Cary R. Obes Sci Pract Original Articles INTRODUCTION: Obesity is linked to altered activation in reward and control brain circuitry; however, the associated brain activity related to successful or unsuccessful weight loss (WL) is unclear. METHODS: Adults with obesity (N = 75) completed a baseline functional magnetic resonance imaging (fMRI) scan before entering a WL intervention (ie,3‐month diet and physical activity [PA] program). We conducted an exploratory analysis to identify the contributions of baseline brain activation, adherence behavior patterns, and the associated connections to WL at the conclusion of a 3‐month WL intervention. Food cue‐reactivity brain regions were functionally identified using fMRI to index brain activation to food vs nonfood cues. Food consumption, PA, and class attendance were collected weekly during the 3‐month intervention. RESULTS: The left middle frontal gyrus (L‐MFG, BA 46) and right middle frontal gyrus (R‐MFG; BA 9) were positively activated when viewing food compared with nonfood images. Structural equation modeling with bootstrapping was used to investigate a hypothesized path model and revealed the following significant paths: (1) attendance to 3‐month WL, (2) R‐MFG to attendance, and (3) indirect effects of R‐MFG through attendance on WL. CONCLUSION: Findings suggest that brain activation to appetitive food cues predicts future WL through mediating session attendance, diet, and PA. This study contributes to the growing evidence of the importance of food cue reactivity and self‐regulation brain regions and their impact on WL outcomes. John Wiley and Sons Inc. 2020-02-25 /pmc/articles/PMC7278911/ /pubmed/32523717 http://dx.doi.org/10.1002/osp4.403 Text en © 2020 The Authors. Obesity Science & Practice published by World Obesity and The Obesity Society and John Wiley & Sons Ltd This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Szabo‐Reed, Amanda N.
Martin, Laura E.
Hu, Jinxiang
Yeh, Hung‐Wen
Powell, Joshua
Lepping, Rebecca J.
Patrician, Trisha M.
Breslin, Florance J.
Donnelly, Joseph E.
Savage, Cary R.
Modeling interactions between brain function, diet adherence behaviors, and weight loss success
title Modeling interactions between brain function, diet adherence behaviors, and weight loss success
title_full Modeling interactions between brain function, diet adherence behaviors, and weight loss success
title_fullStr Modeling interactions between brain function, diet adherence behaviors, and weight loss success
title_full_unstemmed Modeling interactions between brain function, diet adherence behaviors, and weight loss success
title_short Modeling interactions between brain function, diet adherence behaviors, and weight loss success
title_sort modeling interactions between brain function, diet adherence behaviors, and weight loss success
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7278911/
https://www.ncbi.nlm.nih.gov/pubmed/32523717
http://dx.doi.org/10.1002/osp4.403
work_keys_str_mv AT szaboreedamandan modelinginteractionsbetweenbrainfunctiondietadherencebehaviorsandweightlosssuccess
AT martinlaurae modelinginteractionsbetweenbrainfunctiondietadherencebehaviorsandweightlosssuccess
AT hujinxiang modelinginteractionsbetweenbrainfunctiondietadherencebehaviorsandweightlosssuccess
AT yehhungwen modelinginteractionsbetweenbrainfunctiondietadherencebehaviorsandweightlosssuccess
AT powelljoshua modelinginteractionsbetweenbrainfunctiondietadherencebehaviorsandweightlosssuccess
AT leppingrebeccaj modelinginteractionsbetweenbrainfunctiondietadherencebehaviorsandweightlosssuccess
AT patriciantrisham modelinginteractionsbetweenbrainfunctiondietadherencebehaviorsandweightlosssuccess
AT breslinflorancej modelinginteractionsbetweenbrainfunctiondietadherencebehaviorsandweightlosssuccess
AT donnellyjosephe modelinginteractionsbetweenbrainfunctiondietadherencebehaviorsandweightlosssuccess
AT savagecaryr modelinginteractionsbetweenbrainfunctiondietadherencebehaviorsandweightlosssuccess