Cargando…

SMAD4 and the TGFβ Pathway in Patients with Pancreatic Ductal Adenocarcinoma

Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer death worldwide. PDAC is an aggressive disease with an 11-month median overall survival and a five-year survival of less than 5%. Incidence of PDAC is constantly increasing and is predicted to become the second leading cau...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dardare, Julie, Witz, Andréa, Merlin, Jean-Louis, Gilson, Pauline, Harlé, Alexandre
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7278913/ https://www.ncbi.nlm.nih.gov/pubmed/32429474 http://dx.doi.org/10.3390/ijms21103534

Ejemplares similares

Epithelial to Mesenchymal Transition in Patients with Pancreatic Ductal Adenocarcinoma: State-of-the-Art and Therapeutic Opportunities
por: Dardare, Julie, et al.
Publicado: (2021)

DDB2 represses epithelial-to-mesenchymal transition and sensitizes pancreatic ductal adenocarcinoma cells to chemotherapy
por: Dardare, Julie, et al.
Publicado: (2022)

ESR1 Gene Mutations and Liquid Biopsy in ER-Positive Breast Cancers: A Small Step Forward, a Giant Leap for Personalization of Endocrine Therapy?
por: Betz, Margaux, et al.
Publicado: (2023)

CRISPR/Cas9-mediated knock-in of BRCA1/2 mutations restores response to olaparib in pancreatic cancer cell lines
por: Witz, Andréa, et al.
Publicado: (2023)

Validation of the Idylla GeneFusion assay to detect fusions and MET exon-skipping in non-small cell lung cancers
por: Gilson, Pauline, et al.
Publicado: (2023)

Emerging Roles of DDB2 in Cancer
por: Gilson, Pauline, et al.
Publicado: (2019)

Agmatinase facilitates the tumorigenesis of pancreatic adenocarcinoma through the TGFβ/Smad pathway
por: Zhang, Yue, et al.
Publicado: (2022)

miR-367 promotes epithelial-to-mesenchymal transition and invasion of pancreatic ductal adenocarcinoma cells by targeting the Smad7-TGF-β signalling pathway
por: Zhu, Z, et al.
Publicado: (2015)

Detection of Microsatellite Instability: State of the Art and Future Applications in Circulating Tumour DNA (ctDNA)
por: Gilson, Pauline, et al.
Publicado: (2021)

Deciphering Tumour Heterogeneity: From Tissue to Liquid Biopsy
por: Gilson, Pauline, et al.
Publicado: (2022)

Differential roles of Smad2 and Smad3 in the regulation of TGF-β1-mediated growth inhibition and cell migration in pancreatic ductal adenocarcinoma cells: control by Rac1
por: Ungefroren, Hendrik, et al.
Publicado: (2011)

Thrombospondin-1 overexpression stimulates loss of Smad4 and accelerates malignant behavior via TGF-β signal activation in pancreatic ductal adenocarcinoma
por: Matsumura, Kazuki, et al.
Publicado: (2022)

Linc-pint inhibits early stage pancreatic ductal adenocarcinoma growth through TGF-β pathway activation
por: Lu, Huimin, et al.
Publicado: (2019)

FUBP1 mediates the growth and metastasis through TGFβ/Smad signaling in pancreatic adenocarcinoma
por: Zhang, Yue, et al.
Publicado: (2021)

GPR37 promotes the malignancy of lung adenocarcinoma via TGF-β/Smad pathway
por: Wang, Jian, et al.
Publicado: (2020)

Overexpression of MUC1 Induces Non-Canonical TGF-β Signaling in Pancreatic Ductal Adenocarcinoma
por: Bose, Mukulika, et al.
Publicado: (2022)

SMAD4 Loss triggers the phenotypic changes of pancreatic ductal adenocarcinoma cells
por: Chen, Yu-Wen, et al.
Publicado: (2014)

The TGF-β/Smad4 Signaling Pathway in Pancreatic Carcinogenesis and Its Clinical Significance
por: Ahmed, Sunjida, et al.
Publicado: (2017)

Apoptotic pathways in pancreatic ductal adenocarcinoma
por: Hamacher, Rainer, et al.
Publicado: (2008)

Correlation of TNF-α and TGF-β polymorphisms with protein levels in pancreatic ductal adenocarcinoma and colorectal cancer
por: Zagozda, Małgorzata, et al.
Publicado: (2019)

Ral GTPase promotes metastasis of pancreatic ductal adenocarcinoma via elevation of TGF-β1 production
por: Cao, Mingxin, et al.
Publicado: (2023)

The Role of SMAD4 Inactivation in Epithelial–Mesenchymal Plasticity of Pancreatic Ductal Adenocarcinoma: The Missing Link?
por: Racu, Marie-Lucie, et al.
Publicado: (2022)

TGF-β/Smad Signaling Pathway in Tubulointerstitial Fibrosis
por: Yu, Xiao-Yong, et al.
Publicado: (2022)

Role of PLEXIND1/TGFβ Signaling Axis in Pancreatic Ductal Adenocarcinoma Progression Correlates with the Mutational Status of KRAS
por: Vivekanandhan, Sneha, et al.
Publicado: (2021)

Cinobufacini Inhibits the Development of Pancreatic Cancer Cells through the TGFβ/Smads Pathway of Pancreatic Stellate Cells
por: Li, Quan-Wang, et al.
Publicado: (2022)

SMAD4 Positive Pancreatic Ductal Adenocarcinomas Are Associated with Better Outcomes in Patients Receiving FOLFIRINOX-Based Neoadjuvant Therapy
por: Racu, Marie-Lucie, et al.
Publicado: (2023)

Mimics of pancreatic ductal adenocarcinoma
por: Al-Hawary, Mahmoud M., et al.
Publicado: (2013)

Expression analysis of the TGF-β/SMAD target genes in adenocarcinoma of esophagogastric junction
por: Peng, Defeng, et al.
Publicado: (2016)

A study of Smad4, Smad6 and Smad7 in Surgically Resected Samples of Pancreatic Ductal Adenocarcinoma and Their Correlation with Clinicopathological Parameters and Patient Survival
por: Singh, Puneet, et al.
Publicado: (2011)

Rac1b negatively regulates TGF-β1-induced cell motility in pancreatic ductal epithelial cells by suppressing Smad signalling
por: Ungefroren, Hendrik, et al.
Publicado: (2013)

AK2 Promotes the Migration and Invasion of Lung Adenocarcinoma by Activating TGF-β/Smad Pathway In vitro and In vivo
por: Cai, Fangfang, et al.
Publicado: (2021)

Matrine Suppresses Pancreatic Fibrosis by Regulating TGF-β/Smad Signaling in Rats
por: Liu, Pi, et al.
Publicado: (2019)

Evaluation of KRAS, NRAS and BRAF mutations detection in plasma using an automated system for patients with metastatic colorectal cancer
por: Franczak, Claire, et al.
Publicado: (2020)

TGF-β/Smad signaling through DOCK4 facilitates lung adenocarcinoma metastasis
por: Yu, Jia-Ray, et al.
Publicado: (2015)

Clinicopathological significance of SMAD4 loss in pancreatic ductal adenocarcinomas: a systematic review and meta-analysis
por: Wang, Jin-Dao, et al.
Publicado: (2016)

Evaluation of the Idylla ctEGFR mutation assay to detect EGFR mutations in plasma from patients with non-small cell lung cancers
por: Gilson, Pauline, et al.
Publicado: (2021)

The clinical relevance of the Hippo pathway in pancreatic ductal adenocarcinoma
por: Drexler, Richard, et al.
Publicado: (2020)

Pancreatic Ductal Adenocarcinoma Associated with Autoimmune Pancreatitis
por: Pezzilli, Raffaele, et al.
Publicado: (2011)

An inhibitory role of NEK6 in TGFβ/Smad signaling pathway
por: Zuo, Jie, et al.
Publicado: (2015)

Somatic SMAD3-activating mutations cause melorheostosis by up-regulating the TGF-β/SMAD pathway
por: Kang, Heeseog, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_kd6alvtva5efdfr0nr343ggd82