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Coiled-Coils: The Molecular Zippers that Self-Assemble Protein Nanostructures

Coiled-coils, the bundles of intertwined helical protein motifs, have drawn much attention as versatile molecular toolkits. Because of programmable interaction specificity and affinity as well as well-established sequence-to-structure relationships, coiled-coils have been used as subunits that self-...

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Autor principal: Park, Won Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7278914/
https://www.ncbi.nlm.nih.gov/pubmed/32438665
http://dx.doi.org/10.3390/ijms21103584
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author Park, Won Min
author_facet Park, Won Min
author_sort Park, Won Min
collection PubMed
description Coiled-coils, the bundles of intertwined helical protein motifs, have drawn much attention as versatile molecular toolkits. Because of programmable interaction specificity and affinity as well as well-established sequence-to-structure relationships, coiled-coils have been used as subunits that self-assemble various molecular complexes in a range of fields. In this review, I describe recent advances in the field of protein nanotechnology, with a focus on programming assembly of protein nanostructures using coiled-coil modules. Modular design approaches to converting the helical motifs into self-assembling building blocks are described, followed by a discussion on the molecular basis and principles underlying the modular designs. This review also provides a summary of recently developed nanostructures with a variety of structural features, which are in categories of unbounded nanostructures, discrete nanoparticles, and well-defined origami nanostructures. Challenges existing in current design strategies, as well as desired improvements for controls over material properties and functionalities for applications, are also provided.
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spelling pubmed-72789142020-06-15 Coiled-Coils: The Molecular Zippers that Self-Assemble Protein Nanostructures Park, Won Min Int J Mol Sci Review Coiled-coils, the bundles of intertwined helical protein motifs, have drawn much attention as versatile molecular toolkits. Because of programmable interaction specificity and affinity as well as well-established sequence-to-structure relationships, coiled-coils have been used as subunits that self-assemble various molecular complexes in a range of fields. In this review, I describe recent advances in the field of protein nanotechnology, with a focus on programming assembly of protein nanostructures using coiled-coil modules. Modular design approaches to converting the helical motifs into self-assembling building blocks are described, followed by a discussion on the molecular basis and principles underlying the modular designs. This review also provides a summary of recently developed nanostructures with a variety of structural features, which are in categories of unbounded nanostructures, discrete nanoparticles, and well-defined origami nanostructures. Challenges existing in current design strategies, as well as desired improvements for controls over material properties and functionalities for applications, are also provided. MDPI 2020-05-19 /pmc/articles/PMC7278914/ /pubmed/32438665 http://dx.doi.org/10.3390/ijms21103584 Text en © 2020 by the author. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Park, Won Min
Coiled-Coils: The Molecular Zippers that Self-Assemble Protein Nanostructures
title Coiled-Coils: The Molecular Zippers that Self-Assemble Protein Nanostructures
title_full Coiled-Coils: The Molecular Zippers that Self-Assemble Protein Nanostructures
title_fullStr Coiled-Coils: The Molecular Zippers that Self-Assemble Protein Nanostructures
title_full_unstemmed Coiled-Coils: The Molecular Zippers that Self-Assemble Protein Nanostructures
title_short Coiled-Coils: The Molecular Zippers that Self-Assemble Protein Nanostructures
title_sort coiled-coils: the molecular zippers that self-assemble protein nanostructures
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7278914/
https://www.ncbi.nlm.nih.gov/pubmed/32438665
http://dx.doi.org/10.3390/ijms21103584
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