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Coiled-Coils: The Molecular Zippers that Self-Assemble Protein Nanostructures
Coiled-coils, the bundles of intertwined helical protein motifs, have drawn much attention as versatile molecular toolkits. Because of programmable interaction specificity and affinity as well as well-established sequence-to-structure relationships, coiled-coils have been used as subunits that self-...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7278914/ https://www.ncbi.nlm.nih.gov/pubmed/32438665 http://dx.doi.org/10.3390/ijms21103584 |
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author | Park, Won Min |
author_facet | Park, Won Min |
author_sort | Park, Won Min |
collection | PubMed |
description | Coiled-coils, the bundles of intertwined helical protein motifs, have drawn much attention as versatile molecular toolkits. Because of programmable interaction specificity and affinity as well as well-established sequence-to-structure relationships, coiled-coils have been used as subunits that self-assemble various molecular complexes in a range of fields. In this review, I describe recent advances in the field of protein nanotechnology, with a focus on programming assembly of protein nanostructures using coiled-coil modules. Modular design approaches to converting the helical motifs into self-assembling building blocks are described, followed by a discussion on the molecular basis and principles underlying the modular designs. This review also provides a summary of recently developed nanostructures with a variety of structural features, which are in categories of unbounded nanostructures, discrete nanoparticles, and well-defined origami nanostructures. Challenges existing in current design strategies, as well as desired improvements for controls over material properties and functionalities for applications, are also provided. |
format | Online Article Text |
id | pubmed-7278914 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-72789142020-06-15 Coiled-Coils: The Molecular Zippers that Self-Assemble Protein Nanostructures Park, Won Min Int J Mol Sci Review Coiled-coils, the bundles of intertwined helical protein motifs, have drawn much attention as versatile molecular toolkits. Because of programmable interaction specificity and affinity as well as well-established sequence-to-structure relationships, coiled-coils have been used as subunits that self-assemble various molecular complexes in a range of fields. In this review, I describe recent advances in the field of protein nanotechnology, with a focus on programming assembly of protein nanostructures using coiled-coil modules. Modular design approaches to converting the helical motifs into self-assembling building blocks are described, followed by a discussion on the molecular basis and principles underlying the modular designs. This review also provides a summary of recently developed nanostructures with a variety of structural features, which are in categories of unbounded nanostructures, discrete nanoparticles, and well-defined origami nanostructures. Challenges existing in current design strategies, as well as desired improvements for controls over material properties and functionalities for applications, are also provided. MDPI 2020-05-19 /pmc/articles/PMC7278914/ /pubmed/32438665 http://dx.doi.org/10.3390/ijms21103584 Text en © 2020 by the author. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Park, Won Min Coiled-Coils: The Molecular Zippers that Self-Assemble Protein Nanostructures |
title | Coiled-Coils: The Molecular Zippers that Self-Assemble Protein Nanostructures |
title_full | Coiled-Coils: The Molecular Zippers that Self-Assemble Protein Nanostructures |
title_fullStr | Coiled-Coils: The Molecular Zippers that Self-Assemble Protein Nanostructures |
title_full_unstemmed | Coiled-Coils: The Molecular Zippers that Self-Assemble Protein Nanostructures |
title_short | Coiled-Coils: The Molecular Zippers that Self-Assemble Protein Nanostructures |
title_sort | coiled-coils: the molecular zippers that self-assemble protein nanostructures |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7278914/ https://www.ncbi.nlm.nih.gov/pubmed/32438665 http://dx.doi.org/10.3390/ijms21103584 |
work_keys_str_mv | AT parkwonmin coiledcoilsthemolecularzippersthatselfassembleproteinnanostructures |