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Carbonic Anhydrase Sensitivity to Pesticides: Perspectives for Biomarker Development
Carbonic anhydrase (CA) is a widespread metalloenzyme playing a pivotal role in several physiological processes. Many studies have demonstrated the in vitro and in vivo sensitivity of CA to the exposure to several classes of pesticides in both humans and wildlife. This review aims to analyze and to...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7278955/ https://www.ncbi.nlm.nih.gov/pubmed/32443560 http://dx.doi.org/10.3390/ijms21103562 |
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author | Lionetto, Maria Giulia Caricato, Roberto Giordano, Maria Elena |
author_facet | Lionetto, Maria Giulia Caricato, Roberto Giordano, Maria Elena |
author_sort | Lionetto, Maria Giulia |
collection | PubMed |
description | Carbonic anhydrase (CA) is a widespread metalloenzyme playing a pivotal role in several physiological processes. Many studies have demonstrated the in vitro and in vivo sensitivity of CA to the exposure to several classes of pesticides in both humans and wildlife. This review aims to analyze and to discuss the literature available in this field, providing a comprehensive view useful to foresee perspectives for the development of novel CA-based pesticide biomarkers. The analysis of the available data highlighted the ability of several pesticide molecules to interact directly with the enzyme in humans and wildlife and to inhibit CA activity in vitro and in vivo, with possible alterations of key physiological functions. The analysis disclosed key areas of further research and, at the same time, identified some perspectives for the development of novel CA-based sensitive biomarkers to pesticide exposure, suitable to be used in several fields from human biomonitoring in occupational and environmental medicine to environmental monitoring on non-target species. |
format | Online Article Text |
id | pubmed-7278955 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-72789552020-06-15 Carbonic Anhydrase Sensitivity to Pesticides: Perspectives for Biomarker Development Lionetto, Maria Giulia Caricato, Roberto Giordano, Maria Elena Int J Mol Sci Review Carbonic anhydrase (CA) is a widespread metalloenzyme playing a pivotal role in several physiological processes. Many studies have demonstrated the in vitro and in vivo sensitivity of CA to the exposure to several classes of pesticides in both humans and wildlife. This review aims to analyze and to discuss the literature available in this field, providing a comprehensive view useful to foresee perspectives for the development of novel CA-based pesticide biomarkers. The analysis of the available data highlighted the ability of several pesticide molecules to interact directly with the enzyme in humans and wildlife and to inhibit CA activity in vitro and in vivo, with possible alterations of key physiological functions. The analysis disclosed key areas of further research and, at the same time, identified some perspectives for the development of novel CA-based sensitive biomarkers to pesticide exposure, suitable to be used in several fields from human biomonitoring in occupational and environmental medicine to environmental monitoring on non-target species. MDPI 2020-05-18 /pmc/articles/PMC7278955/ /pubmed/32443560 http://dx.doi.org/10.3390/ijms21103562 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Lionetto, Maria Giulia Caricato, Roberto Giordano, Maria Elena Carbonic Anhydrase Sensitivity to Pesticides: Perspectives for Biomarker Development |
title | Carbonic Anhydrase Sensitivity to Pesticides: Perspectives for Biomarker Development |
title_full | Carbonic Anhydrase Sensitivity to Pesticides: Perspectives for Biomarker Development |
title_fullStr | Carbonic Anhydrase Sensitivity to Pesticides: Perspectives for Biomarker Development |
title_full_unstemmed | Carbonic Anhydrase Sensitivity to Pesticides: Perspectives for Biomarker Development |
title_short | Carbonic Anhydrase Sensitivity to Pesticides: Perspectives for Biomarker Development |
title_sort | carbonic anhydrase sensitivity to pesticides: perspectives for biomarker development |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7278955/ https://www.ncbi.nlm.nih.gov/pubmed/32443560 http://dx.doi.org/10.3390/ijms21103562 |
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