PHLD Class Proteins: A Family of New Players in the p53 Network

The Pleckstrin Homology-like Domain (PHLD) class of proteins are multifunctional proteins. The class is comprised of two families of proteins, PHLDA and PHLDB, each with 3 members. All members of the families possess a pleckstrin homology (PH) domain. Though identified nearly 30 years ago, this clas...

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Detalles Bibliográficos
Autores principales: Fuselier, Taylor T., Lu, Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7278972/
https://www.ncbi.nlm.nih.gov/pubmed/32429563
http://dx.doi.org/10.3390/ijms21103543
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author Fuselier, Taylor T.
Lu, Hua
author_facet Fuselier, Taylor T.
Lu, Hua
author_sort Fuselier, Taylor T.
collection PubMed
description The Pleckstrin Homology-like Domain (PHLD) class of proteins are multifunctional proteins. The class is comprised of two families of proteins, PHLDA and PHLDB, each with 3 members. All members of the families possess a pleckstrin homology (PH) domain. Though identified nearly 30 years ago, this class of proteins remains understudied with PHLDA family members receiving most of the research attention. Recent studies have also begun to reveal the functions of the PHLDB family proteins in regulation of p53 and AKT signaling pathways important for cancer and metabolism. This review will discuss current research and offer some prospects on the possible roles of both families in cancer and metabolism.
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spelling pubmed-72789722020-06-15 PHLD Class Proteins: A Family of New Players in the p53 Network Fuselier, Taylor T. Lu, Hua Int J Mol Sci Review The Pleckstrin Homology-like Domain (PHLD) class of proteins are multifunctional proteins. The class is comprised of two families of proteins, PHLDA and PHLDB, each with 3 members. All members of the families possess a pleckstrin homology (PH) domain. Though identified nearly 30 years ago, this class of proteins remains understudied with PHLDA family members receiving most of the research attention. Recent studies have also begun to reveal the functions of the PHLDB family proteins in regulation of p53 and AKT signaling pathways important for cancer and metabolism. This review will discuss current research and offer some prospects on the possible roles of both families in cancer and metabolism. MDPI 2020-05-17 /pmc/articles/PMC7278972/ /pubmed/32429563 http://dx.doi.org/10.3390/ijms21103543 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Fuselier, Taylor T.
Lu, Hua
PHLD Class Proteins: A Family of New Players in the p53 Network
title PHLD Class Proteins: A Family of New Players in the p53 Network
title_full PHLD Class Proteins: A Family of New Players in the p53 Network
title_fullStr PHLD Class Proteins: A Family of New Players in the p53 Network
title_full_unstemmed PHLD Class Proteins: A Family of New Players in the p53 Network
title_short PHLD Class Proteins: A Family of New Players in the p53 Network
title_sort phld class proteins: a family of new players in the p53 network
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7278972/
https://www.ncbi.nlm.nih.gov/pubmed/32429563
http://dx.doi.org/10.3390/ijms21103543
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