Cargando…

Polyphenols with Anti-Amyloid β Aggregation Show Potential Risk of Toxicity Via Pro-Oxidant Properties

Alzheimer’s disease (AD) is the most common form of dementia among older people. Amyloid β (Aβ) aggregation has been the focus for a therapeutic target for the treatment of AD. Naturally occurring polyphenols have an inhibitory effect on Aβ aggregation and have attracted a lot of attention for the d...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kobayashi, Hatasu, Murata, Mariko, Kawanishi, Shosuke, Oikawa, Shinji
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7279003/ https://www.ncbi.nlm.nih.gov/pubmed/32443552 http://dx.doi.org/10.3390/ijms21103561

Ejemplares similares

Taurine Attenuates Carcinogenicity in Ulcerative Colitis-Colorectal Cancer Mouse Model
por: Wang, Guifeng, et al.
Publicado: (2020)

Oxidative DNA Damage by N(4)-hydroxycytidine, a Metabolite of the SARS-CoV-2 Antiviral Molnupiravir
por: Kobayashi, Hatasu, et al.
Publicado: (2022)

CD44v9 Induces Stem Cell-Like Phenotypes in Human Cholangiocarcinoma
por: Suwannakul, Nattawan, et al.
Publicado: (2020)

Nitrative DNA damage in lung epithelial cells exposed to indium nanoparticles and indium ions
por: Ahmed, Sharif, et al.
Publicado: (2020)

Copper-mediated DNA damage caused by purpurin, a natural anthraquinone
por: Kobayashi, Hatasu, et al.
Publicado: (2022)

Targeting fructose metabolism by glucose transporter 5 regulation in human cholangiocarcinoma
por: Suwannakul, Nattawan, et al.
Publicado: (2021)

Nitrative and oxidative DNA damage in infection-related carcinogenesis in relation to cancer stem cells
por: Kawanishi, Shosuke, et al.
Publicado: (2017)

Nitrative DNA damage in cultured macrophages exposed to indium oxide
por: Afroz, Tahmina, et al.
Publicado: (2017)

Mechanism of Oxidative DNA Damage Induced by a Heterocyclic Amine, 2‐Amino‐3,8‐dimethylimidazo[4,5‐f]quinoxaline
por: Murata, Mariko, et al.
Publicado: (1999)

Oxidative Stress and Its Significant Roles in Neurodegenerative Diseases and Cancer
por: Thanan, Raynoo, et al.
Publicado: (2014)

Distinct mechanisms of oxidative DNA damage induced by carcinogenic nickel subsulfide and nickel oxides.
por: Kawanishi, Shosuke, et al.
Publicado: (2002)

Oxidative DNA Damage Induced by a Metabolite of 2–Naphthylamine, a Smoking‐related Bladder Carcinogen
por: Ohnishi, Shiho, et al.
Publicado: (2002)

Hydroxyurea Induces Site‐specific DNA Damage via Formation of Hydrogen Peroxide and Nitric Oxide
por: Sakano, Katsuhisa, et al.
Publicado: (2001)

Proteomic analysis of the monkey hippocampus for elucidating ischemic resistance
por: Mori, Yurie, et al.
Publicado: (2020)

Role of Nitrative and Oxidative DNA Damage in Inflammation-Related Carcinogenesis
por: Murata, Mariko, et al.
Publicado: (2012)

Oxidative DNA Damage Induced by an N‐Hydroxy Metabolite of Carcinogenic 4‐Dimethylaminoazobenzene
por: Ohnishi, Shiho, et al.
Publicado: (2001)

Relationships of Alpha-SMA-Positive Fibroblasts and SDF-1-Positive Tumor Cells with Neoangiogenesis in Nasopharyngeal Carcinoma
por: Wang, Shumin, et al.
Publicado: (2014)

The Effects of Latrepirdine on Amyloid-β Aggregation and Toxicity
por: Porter, Tenielle, et al.
Publicado: (2016)

Nuclear Localization of COX-2 in relation to the Expression of Stemness Markers in Urinary Bladder Cancer
por: Thanan, Raynoo, et al.
Publicado: (2012)

Amyloid β-Sheet Mimics that Antagonize Amyloid Aggregation and Reduce Amyloid Toxicity
por: Cheng, Pin-Nan, et al.
Publicado: (2012)

Multicomponent Synthesis of Polyphenols and Their In Vitro Evaluation as Potential β-Amyloid Aggregation Inhibitors
por: Galante, Denise, et al.
Publicado: (2019)

Inflammation-Related DNA Damage and Cancer Stem Cell Markers in Nasopharyngeal Carcinoma
por: Wang, Shumin, et al.
Publicado: (2016)

Overexpression of CD44 Variant 9: A Novel Cancer Stem Cell Marker in Human Cholangiocarcinoma in Relation to Inflammation
por: Suwannakul, Nattawan, et al.
Publicado: (2018)

Knockdown of TFRC suppressed the progression of nasopharyngeal carcinoma by downregulating the PI3K/Akt/mTOR pathway
por: Feng, Guofei, et al.
Publicado: (2023)

Current understanding of metal-dependent amyloid-β aggregation and toxicity
por: Yi, Yelim, et al.
Publicado: (2022)

Crosstalk between DNA Damage and Inflammation in the Multiple Steps of Carcinogenesis
por: Kawanishi, Shosuke, et al.
Publicado: (2017)

Oxidation destabilizes toxic amyloid beta peptide aggregation
por: Razzokov, J., et al.
Publicado: (2019)

Interactions between Amyloid-β and Tau Fragments Promote Aberrant Aggregates: Implications for Amyloid Toxicity
por: Do, Thanh D., et al.
Publicado: (2014)

Unveiling the impact of oxidation-driven endogenous protein interactions on the dynamics of amyloid-β aggregation and toxicity
por: Du, Zhi, et al.
Publicado: (2023)

Inhibition of β-Amyloid Aggregation in Alzheimer’s Disease: The Key Role of (Pro)electrophilic Warheads
por: Basagni, Filippo, et al.
Publicado: (2022)

Green Tea Polyphenol Epigallocatechin-Gallate in Amyloid Aggregation and Neurodegenerative Diseases
por: Fernandes, Luiza, et al.
Publicado: (2021)

Heptameric Peptide Interferes with Amyloid-β Aggregation by Structural Reorganization of the Toxic Oligomers
por: Bhattacharyya, Rajanya, et al.
Publicado: (2020)

Combination of RERG and ZNF671 methylation rates in circulating cell‐free DNA: A novel biomarker for screening of nasopharyngeal carcinoma
por: Xu, Yifei, et al.
Publicado: (2020)

Influence of Epstein–Barr virus and human papillomavirus infection on macrophage migration inhibitory factor and macrophage polarization in nasopharyngeal carcinoma
por: Feng, Guofei, et al.
Publicado: (2021)

The Effect of Glycosaminoglycans (GAGs) on Amyloid Aggregation and Toxicity
por: Iannuzzi, Clara, et al.
Publicado: (2015)

Polyphenols Modulate Alzheimer’s Amyloid Beta Aggregation in a Structure-Dependent Manner
por: Phan, Huong T. T., et al.
Publicado: (2019)

The polyphenolic phytoalexin polydatin inhibits amyloid aggregation of recombinant human prion protein
por: Sirohi, Preeti Rana, et al.
Publicado: (2021)

Lipid Rafts: Linking Alzheimer's Amyloid-β Production, Aggregation, and Toxicity at Neuronal Membranes
por: Rushworth, Jo V., et al.
Publicado: (2010)

Impact of sphingosine and acetylsphingosines on the aggregation and toxicity of metal-free and metal-treated amyloid-β
por: Yi, Yelim, et al.
Publicado: (2020)

Members of the GADD45 Protein Family Show Distinct Propensities to form Toxic Amyloid-Like Aggregates in Physiological Conditions
por: Smaldone, Giovanni, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_2aqdu9kf8rlhh4gi2152a4tg6j