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Instability of Non-Standard Microsatellites in Relation to Prognosis in Metastatic Colorectal Cancer Patients

Very few data are reported in the literature on the association between elevated microsatellite alterations at selected tetranucleotide repeats (EMAST) and prognosis in advanced colorectal cancer. Moreover, there is no information available in relation to the response to antiangiogenic treatment. We...

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Autores principales: Pirini, Francesca, Pasini, Luigi, Tedaldi, Gianluca, Scarpi, Emanuela, Marisi, Giorgia, Molinari, Chiara, Calistri, Daniele, Passardi, Alessandro, Ulivi, Paola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7279028/
https://www.ncbi.nlm.nih.gov/pubmed/32429465
http://dx.doi.org/10.3390/ijms21103532
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author Pirini, Francesca
Pasini, Luigi
Tedaldi, Gianluca
Scarpi, Emanuela
Marisi, Giorgia
Molinari, Chiara
Calistri, Daniele
Passardi, Alessandro
Ulivi, Paola
author_facet Pirini, Francesca
Pasini, Luigi
Tedaldi, Gianluca
Scarpi, Emanuela
Marisi, Giorgia
Molinari, Chiara
Calistri, Daniele
Passardi, Alessandro
Ulivi, Paola
author_sort Pirini, Francesca
collection PubMed
description Very few data are reported in the literature on the association between elevated microsatellite alterations at selected tetranucleotide repeats (EMAST) and prognosis in advanced colorectal cancer. Moreover, there is no information available in relation to the response to antiangiogenic treatment. We analyzed EMAST and vascular endothelial growth factor-B (VEGF-B) microsatellite status, together with standard microsatellite instability (MSI), in relation to prognosis in 141 patients with metastatic colorectal cancer (mCRC) treated with chemotherapy (CT) alone (n = 51) or chemotherapy with bevacizumab (B) (CT + B; n = 90). High MSI (MSI-H) was detected in 3% of patients and was associated with progression-free survival (PFS; p = 0.005) and overall survival (OS; p < 0.0001). A total of 8% of cases showed EMAST instability, which was associated with worse PFS (p = 0.0006) and OS (p < 0.0001) in patients treated with CT + B. A total of 24.2% of patients showed VEGF-B instability associated with poorer outcome in (p = 0.005) in the CT arm. In conclusion, our analysis indicated that EMAST instability is associated with worse prognosis, particularly evident in patients receiving CT + B.
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spelling pubmed-72790282020-06-15 Instability of Non-Standard Microsatellites in Relation to Prognosis in Metastatic Colorectal Cancer Patients Pirini, Francesca Pasini, Luigi Tedaldi, Gianluca Scarpi, Emanuela Marisi, Giorgia Molinari, Chiara Calistri, Daniele Passardi, Alessandro Ulivi, Paola Int J Mol Sci Article Very few data are reported in the literature on the association between elevated microsatellite alterations at selected tetranucleotide repeats (EMAST) and prognosis in advanced colorectal cancer. Moreover, there is no information available in relation to the response to antiangiogenic treatment. We analyzed EMAST and vascular endothelial growth factor-B (VEGF-B) microsatellite status, together with standard microsatellite instability (MSI), in relation to prognosis in 141 patients with metastatic colorectal cancer (mCRC) treated with chemotherapy (CT) alone (n = 51) or chemotherapy with bevacizumab (B) (CT + B; n = 90). High MSI (MSI-H) was detected in 3% of patients and was associated with progression-free survival (PFS; p = 0.005) and overall survival (OS; p < 0.0001). A total of 8% of cases showed EMAST instability, which was associated with worse PFS (p = 0.0006) and OS (p < 0.0001) in patients treated with CT + B. A total of 24.2% of patients showed VEGF-B instability associated with poorer outcome in (p = 0.005) in the CT arm. In conclusion, our analysis indicated that EMAST instability is associated with worse prognosis, particularly evident in patients receiving CT + B. MDPI 2020-05-16 /pmc/articles/PMC7279028/ /pubmed/32429465 http://dx.doi.org/10.3390/ijms21103532 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Pirini, Francesca
Pasini, Luigi
Tedaldi, Gianluca
Scarpi, Emanuela
Marisi, Giorgia
Molinari, Chiara
Calistri, Daniele
Passardi, Alessandro
Ulivi, Paola
Instability of Non-Standard Microsatellites in Relation to Prognosis in Metastatic Colorectal Cancer Patients
title Instability of Non-Standard Microsatellites in Relation to Prognosis in Metastatic Colorectal Cancer Patients
title_full Instability of Non-Standard Microsatellites in Relation to Prognosis in Metastatic Colorectal Cancer Patients
title_fullStr Instability of Non-Standard Microsatellites in Relation to Prognosis in Metastatic Colorectal Cancer Patients
title_full_unstemmed Instability of Non-Standard Microsatellites in Relation to Prognosis in Metastatic Colorectal Cancer Patients
title_short Instability of Non-Standard Microsatellites in Relation to Prognosis in Metastatic Colorectal Cancer Patients
title_sort instability of non-standard microsatellites in relation to prognosis in metastatic colorectal cancer patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7279028/
https://www.ncbi.nlm.nih.gov/pubmed/32429465
http://dx.doi.org/10.3390/ijms21103532
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