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Instability of Non-Standard Microsatellites in Relation to Prognosis in Metastatic Colorectal Cancer Patients
Very few data are reported in the literature on the association between elevated microsatellite alterations at selected tetranucleotide repeats (EMAST) and prognosis in advanced colorectal cancer. Moreover, there is no information available in relation to the response to antiangiogenic treatment. We...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7279028/ https://www.ncbi.nlm.nih.gov/pubmed/32429465 http://dx.doi.org/10.3390/ijms21103532 |
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author | Pirini, Francesca Pasini, Luigi Tedaldi, Gianluca Scarpi, Emanuela Marisi, Giorgia Molinari, Chiara Calistri, Daniele Passardi, Alessandro Ulivi, Paola |
author_facet | Pirini, Francesca Pasini, Luigi Tedaldi, Gianluca Scarpi, Emanuela Marisi, Giorgia Molinari, Chiara Calistri, Daniele Passardi, Alessandro Ulivi, Paola |
author_sort | Pirini, Francesca |
collection | PubMed |
description | Very few data are reported in the literature on the association between elevated microsatellite alterations at selected tetranucleotide repeats (EMAST) and prognosis in advanced colorectal cancer. Moreover, there is no information available in relation to the response to antiangiogenic treatment. We analyzed EMAST and vascular endothelial growth factor-B (VEGF-B) microsatellite status, together with standard microsatellite instability (MSI), in relation to prognosis in 141 patients with metastatic colorectal cancer (mCRC) treated with chemotherapy (CT) alone (n = 51) or chemotherapy with bevacizumab (B) (CT + B; n = 90). High MSI (MSI-H) was detected in 3% of patients and was associated with progression-free survival (PFS; p = 0.005) and overall survival (OS; p < 0.0001). A total of 8% of cases showed EMAST instability, which was associated with worse PFS (p = 0.0006) and OS (p < 0.0001) in patients treated with CT + B. A total of 24.2% of patients showed VEGF-B instability associated with poorer outcome in (p = 0.005) in the CT arm. In conclusion, our analysis indicated that EMAST instability is associated with worse prognosis, particularly evident in patients receiving CT + B. |
format | Online Article Text |
id | pubmed-7279028 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-72790282020-06-15 Instability of Non-Standard Microsatellites in Relation to Prognosis in Metastatic Colorectal Cancer Patients Pirini, Francesca Pasini, Luigi Tedaldi, Gianluca Scarpi, Emanuela Marisi, Giorgia Molinari, Chiara Calistri, Daniele Passardi, Alessandro Ulivi, Paola Int J Mol Sci Article Very few data are reported in the literature on the association between elevated microsatellite alterations at selected tetranucleotide repeats (EMAST) and prognosis in advanced colorectal cancer. Moreover, there is no information available in relation to the response to antiangiogenic treatment. We analyzed EMAST and vascular endothelial growth factor-B (VEGF-B) microsatellite status, together with standard microsatellite instability (MSI), in relation to prognosis in 141 patients with metastatic colorectal cancer (mCRC) treated with chemotherapy (CT) alone (n = 51) or chemotherapy with bevacizumab (B) (CT + B; n = 90). High MSI (MSI-H) was detected in 3% of patients and was associated with progression-free survival (PFS; p = 0.005) and overall survival (OS; p < 0.0001). A total of 8% of cases showed EMAST instability, which was associated with worse PFS (p = 0.0006) and OS (p < 0.0001) in patients treated with CT + B. A total of 24.2% of patients showed VEGF-B instability associated with poorer outcome in (p = 0.005) in the CT arm. In conclusion, our analysis indicated that EMAST instability is associated with worse prognosis, particularly evident in patients receiving CT + B. MDPI 2020-05-16 /pmc/articles/PMC7279028/ /pubmed/32429465 http://dx.doi.org/10.3390/ijms21103532 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Pirini, Francesca Pasini, Luigi Tedaldi, Gianluca Scarpi, Emanuela Marisi, Giorgia Molinari, Chiara Calistri, Daniele Passardi, Alessandro Ulivi, Paola Instability of Non-Standard Microsatellites in Relation to Prognosis in Metastatic Colorectal Cancer Patients |
title | Instability of Non-Standard Microsatellites in Relation to Prognosis in Metastatic Colorectal Cancer Patients |
title_full | Instability of Non-Standard Microsatellites in Relation to Prognosis in Metastatic Colorectal Cancer Patients |
title_fullStr | Instability of Non-Standard Microsatellites in Relation to Prognosis in Metastatic Colorectal Cancer Patients |
title_full_unstemmed | Instability of Non-Standard Microsatellites in Relation to Prognosis in Metastatic Colorectal Cancer Patients |
title_short | Instability of Non-Standard Microsatellites in Relation to Prognosis in Metastatic Colorectal Cancer Patients |
title_sort | instability of non-standard microsatellites in relation to prognosis in metastatic colorectal cancer patients |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7279028/ https://www.ncbi.nlm.nih.gov/pubmed/32429465 http://dx.doi.org/10.3390/ijms21103532 |
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