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AMPK and the Need to Breathe and Feed: What’s the Matter with Oxygen?

We live and to do so we must breathe and eat, so are we a combination of what we eat and breathe? Here, we will consider this question, and the role in this respect of the AMP-activated protein kinase (AMPK). Emerging evidence suggests that AMPK facilitates central and peripheral reflexes that coord...

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Detalles Bibliográficos
Autores principales: Evans, A. Mark, Hardie, D. Grahame
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7279029/
https://www.ncbi.nlm.nih.gov/pubmed/32429235
http://dx.doi.org/10.3390/ijms21103518
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author Evans, A. Mark
Hardie, D. Grahame
author_facet Evans, A. Mark
Hardie, D. Grahame
author_sort Evans, A. Mark
collection PubMed
description We live and to do so we must breathe and eat, so are we a combination of what we eat and breathe? Here, we will consider this question, and the role in this respect of the AMP-activated protein kinase (AMPK). Emerging evidence suggests that AMPK facilitates central and peripheral reflexes that coordinate breathing and oxygen supply, and contributes to the central regulation of feeding and food choice. We propose, therefore, that oxygen supply to the body is aligned with not only the quantity we eat, but also nutrient-based diet selection, and that the cell-specific expression pattern of AMPK subunit isoforms is critical to appropriate system alignment in this respect. Currently available information on how oxygen supply may be aligned with feeding and food choice, or vice versa, through our motivation to breathe and select particular nutrients is sparse, fragmented and lacks any integrated understanding. By addressing this, we aim to provide the foundations for a clinical perspective that reveals untapped potential, by highlighting how aberrant cell-specific changes in the expression of AMPK subunit isoforms could give rise, in part, to known associations between metabolic disease, such as obesity and type 2 diabetes, sleep-disordered breathing, pulmonary hypertension and acute respiratory distress syndrome.
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spelling pubmed-72790292020-06-15 AMPK and the Need to Breathe and Feed: What’s the Matter with Oxygen? Evans, A. Mark Hardie, D. Grahame Int J Mol Sci Review We live and to do so we must breathe and eat, so are we a combination of what we eat and breathe? Here, we will consider this question, and the role in this respect of the AMP-activated protein kinase (AMPK). Emerging evidence suggests that AMPK facilitates central and peripheral reflexes that coordinate breathing and oxygen supply, and contributes to the central regulation of feeding and food choice. We propose, therefore, that oxygen supply to the body is aligned with not only the quantity we eat, but also nutrient-based diet selection, and that the cell-specific expression pattern of AMPK subunit isoforms is critical to appropriate system alignment in this respect. Currently available information on how oxygen supply may be aligned with feeding and food choice, or vice versa, through our motivation to breathe and select particular nutrients is sparse, fragmented and lacks any integrated understanding. By addressing this, we aim to provide the foundations for a clinical perspective that reveals untapped potential, by highlighting how aberrant cell-specific changes in the expression of AMPK subunit isoforms could give rise, in part, to known associations between metabolic disease, such as obesity and type 2 diabetes, sleep-disordered breathing, pulmonary hypertension and acute respiratory distress syndrome. MDPI 2020-05-15 /pmc/articles/PMC7279029/ /pubmed/32429235 http://dx.doi.org/10.3390/ijms21103518 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Evans, A. Mark
Hardie, D. Grahame
AMPK and the Need to Breathe and Feed: What’s the Matter with Oxygen?
title AMPK and the Need to Breathe and Feed: What’s the Matter with Oxygen?
title_full AMPK and the Need to Breathe and Feed: What’s the Matter with Oxygen?
title_fullStr AMPK and the Need to Breathe and Feed: What’s the Matter with Oxygen?
title_full_unstemmed AMPK and the Need to Breathe and Feed: What’s the Matter with Oxygen?
title_short AMPK and the Need to Breathe and Feed: What’s the Matter with Oxygen?
title_sort ampk and the need to breathe and feed: what’s the matter with oxygen?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7279029/
https://www.ncbi.nlm.nih.gov/pubmed/32429235
http://dx.doi.org/10.3390/ijms21103518
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