Cargando…
Symptomatic Infection is Associated with Prolonged Duration of Viral Shedding in Mild Coronavirus Disease 2019: A Retrospective Study of 110 Children in Wuhan
Information regarding viral shedding in children with coronavirus disease 2019 (COVID-19) was limited. This study aims to investigate the clinical and laboratory characteristics associated with viral shedding in children with mild COVID-19. METHODS: The clinical and laboratory information of 110 chi...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Williams & Wilkins
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7279058/ https://www.ncbi.nlm.nih.gov/pubmed/32379191 http://dx.doi.org/10.1097/INF.0000000000002729 |
_version_ | 1783543474941853696 |
---|---|
author | Lu, Yingying Li, Yi Deng, Wenyue Liu, Mingyang He, Yuanzhi Huang, Lingyue Lv, Mengxue Li, Jianxin Du, Hao |
author_facet | Lu, Yingying Li, Yi Deng, Wenyue Liu, Mingyang He, Yuanzhi Huang, Lingyue Lv, Mengxue Li, Jianxin Du, Hao |
author_sort | Lu, Yingying |
collection | PubMed |
description | Information regarding viral shedding in children with coronavirus disease 2019 (COVID-19) was limited. This study aims to investigate the clinical and laboratory characteristics associated with viral shedding in children with mild COVID-19. METHODS: The clinical and laboratory information of 110 children with COVID-19 at Wuhan Children’s Hospital, Wuhan, China, from January 30 to March 10, 2020, were analyzed retrospectively. RESULTS: The median age was 6 years old. The median period of viral shedding of COVID-19 was 15 days (interquartile range [IQR], 11–20 days) as measured from illness onset to discharge. This period was shorter in asymptomatic patients (26.4%) compared with symptomatic patients (73.6%) (11 days vs. 17 days). Multivariable regression analysis showed increased odds of symptomatic infection was associated with age <6 years (odds ratio [OR] 8.94, 95% confidence interval [CI]: 2.55–31.35; P = 0.001), hypersensitive C-reactive protein >3.0 mg/L (OR 4.89; 95% CI: 1.10–21.75; P = 0.037) and presenting pneumonia in chest radiologic findings (OR 8.45; 95% CI: 2.69–26.61; P < 0.001). Kaplan-Meier analysis displayed symptomatic infection (P < 0.001), fever (P = 0.006), pneumonia (P = 0.003) and lymphocyte counts <2.0 × 10(9)/L (P = 0.008) in children with COVID-19 were associated with prolonged duration of viral shedding in children with COVID-19. CONCLUSION: Prolonged duration of viral shedding in children with COVID-19 was associated with symptomatic infection, fever, pneumonia and lymphocyte count less than 2.0 × 10(9)/L. Monitoring of symptoms could help to know the viral shedding in children with COVID-19. |
format | Online Article Text |
id | pubmed-7279058 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-72790582020-06-29 Symptomatic Infection is Associated with Prolonged Duration of Viral Shedding in Mild Coronavirus Disease 2019: A Retrospective Study of 110 Children in Wuhan Lu, Yingying Li, Yi Deng, Wenyue Liu, Mingyang He, Yuanzhi Huang, Lingyue Lv, Mengxue Li, Jianxin Du, Hao Pediatr Infect Dis J Original Studies Information regarding viral shedding in children with coronavirus disease 2019 (COVID-19) was limited. This study aims to investigate the clinical and laboratory characteristics associated with viral shedding in children with mild COVID-19. METHODS: The clinical and laboratory information of 110 children with COVID-19 at Wuhan Children’s Hospital, Wuhan, China, from January 30 to March 10, 2020, were analyzed retrospectively. RESULTS: The median age was 6 years old. The median period of viral shedding of COVID-19 was 15 days (interquartile range [IQR], 11–20 days) as measured from illness onset to discharge. This period was shorter in asymptomatic patients (26.4%) compared with symptomatic patients (73.6%) (11 days vs. 17 days). Multivariable regression analysis showed increased odds of symptomatic infection was associated with age <6 years (odds ratio [OR] 8.94, 95% confidence interval [CI]: 2.55–31.35; P = 0.001), hypersensitive C-reactive protein >3.0 mg/L (OR 4.89; 95% CI: 1.10–21.75; P = 0.037) and presenting pneumonia in chest radiologic findings (OR 8.45; 95% CI: 2.69–26.61; P < 0.001). Kaplan-Meier analysis displayed symptomatic infection (P < 0.001), fever (P = 0.006), pneumonia (P = 0.003) and lymphocyte counts <2.0 × 10(9)/L (P = 0.008) in children with COVID-19 were associated with prolonged duration of viral shedding in children with COVID-19. CONCLUSION: Prolonged duration of viral shedding in children with COVID-19 was associated with symptomatic infection, fever, pneumonia and lymphocyte count less than 2.0 × 10(9)/L. Monitoring of symptoms could help to know the viral shedding in children with COVID-19. Williams & Wilkins 2020-06-05 2020-07 /pmc/articles/PMC7279058/ /pubmed/32379191 http://dx.doi.org/10.1097/INF.0000000000002729 Text en Copyright © 2020 The Author(s). Published by Wolters Kluwer Health, Inc. This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY) (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. This article is made available via the PMC Open Access Subset for unrestricted re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the COVID-19 pandemic or until permissions are revoked in writing. Upon expiration of these permissions, PMC is granted a perpetual license to make this article available via PMC and Europe PMC, consistent with existing copyright protections. |
spellingShingle | Original Studies Lu, Yingying Li, Yi Deng, Wenyue Liu, Mingyang He, Yuanzhi Huang, Lingyue Lv, Mengxue Li, Jianxin Du, Hao Symptomatic Infection is Associated with Prolonged Duration of Viral Shedding in Mild Coronavirus Disease 2019: A Retrospective Study of 110 Children in Wuhan |
title | Symptomatic Infection is Associated with Prolonged Duration of Viral Shedding in Mild Coronavirus Disease 2019: A Retrospective Study of 110 Children in Wuhan |
title_full | Symptomatic Infection is Associated with Prolonged Duration of Viral Shedding in Mild Coronavirus Disease 2019: A Retrospective Study of 110 Children in Wuhan |
title_fullStr | Symptomatic Infection is Associated with Prolonged Duration of Viral Shedding in Mild Coronavirus Disease 2019: A Retrospective Study of 110 Children in Wuhan |
title_full_unstemmed | Symptomatic Infection is Associated with Prolonged Duration of Viral Shedding in Mild Coronavirus Disease 2019: A Retrospective Study of 110 Children in Wuhan |
title_short | Symptomatic Infection is Associated with Prolonged Duration of Viral Shedding in Mild Coronavirus Disease 2019: A Retrospective Study of 110 Children in Wuhan |
title_sort | symptomatic infection is associated with prolonged duration of viral shedding in mild coronavirus disease 2019: a retrospective study of 110 children in wuhan |
topic | Original Studies |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7279058/ https://www.ncbi.nlm.nih.gov/pubmed/32379191 http://dx.doi.org/10.1097/INF.0000000000002729 |
work_keys_str_mv | AT luyingying symptomaticinfectionisassociatedwithprolongeddurationofviralsheddinginmildcoronavirusdisease2019aretrospectivestudyof110childreninwuhan AT liyi symptomaticinfectionisassociatedwithprolongeddurationofviralsheddinginmildcoronavirusdisease2019aretrospectivestudyof110childreninwuhan AT dengwenyue symptomaticinfectionisassociatedwithprolongeddurationofviralsheddinginmildcoronavirusdisease2019aretrospectivestudyof110childreninwuhan AT liumingyang symptomaticinfectionisassociatedwithprolongeddurationofviralsheddinginmildcoronavirusdisease2019aretrospectivestudyof110childreninwuhan AT heyuanzhi symptomaticinfectionisassociatedwithprolongeddurationofviralsheddinginmildcoronavirusdisease2019aretrospectivestudyof110childreninwuhan AT huanglingyue symptomaticinfectionisassociatedwithprolongeddurationofviralsheddinginmildcoronavirusdisease2019aretrospectivestudyof110childreninwuhan AT lvmengxue symptomaticinfectionisassociatedwithprolongeddurationofviralsheddinginmildcoronavirusdisease2019aretrospectivestudyof110childreninwuhan AT lijianxin symptomaticinfectionisassociatedwithprolongeddurationofviralsheddinginmildcoronavirusdisease2019aretrospectivestudyof110childreninwuhan AT duhao symptomaticinfectionisassociatedwithprolongeddurationofviralsheddinginmildcoronavirusdisease2019aretrospectivestudyof110childreninwuhan |