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TRPV1: Structure, Endogenous Agonists, and Mechanisms

The Transient Receptor Potential Vanilloid 1 (TRPV1) channel is a polymodal protein with functions widely linked to the generation of pain. Several agonists of exogenous and endogenous nature have been described for this ion channel. Nonetheless, detailed mechanisms and description of binding sites...

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Autores principales: Benítez-Angeles, Miguel, Morales-Lázaro, Sara Luz, Juárez-González, Emmanuel, Rosenbaum, Tamara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7279265/
https://www.ncbi.nlm.nih.gov/pubmed/32408609
http://dx.doi.org/10.3390/ijms21103421
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author Benítez-Angeles, Miguel
Morales-Lázaro, Sara Luz
Juárez-González, Emmanuel
Rosenbaum, Tamara
author_facet Benítez-Angeles, Miguel
Morales-Lázaro, Sara Luz
Juárez-González, Emmanuel
Rosenbaum, Tamara
author_sort Benítez-Angeles, Miguel
collection PubMed
description The Transient Receptor Potential Vanilloid 1 (TRPV1) channel is a polymodal protein with functions widely linked to the generation of pain. Several agonists of exogenous and endogenous nature have been described for this ion channel. Nonetheless, detailed mechanisms and description of binding sites have been resolved only for a few endogenous agonists. This review focuses on summarizing discoveries made in this particular field of study and highlighting the fact that studying the molecular details of activation of the channel by different agonists can shed light on biophysical traits that had not been previously demonstrated.
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spelling pubmed-72792652020-06-15 TRPV1: Structure, Endogenous Agonists, and Mechanisms Benítez-Angeles, Miguel Morales-Lázaro, Sara Luz Juárez-González, Emmanuel Rosenbaum, Tamara Int J Mol Sci Review The Transient Receptor Potential Vanilloid 1 (TRPV1) channel is a polymodal protein with functions widely linked to the generation of pain. Several agonists of exogenous and endogenous nature have been described for this ion channel. Nonetheless, detailed mechanisms and description of binding sites have been resolved only for a few endogenous agonists. This review focuses on summarizing discoveries made in this particular field of study and highlighting the fact that studying the molecular details of activation of the channel by different agonists can shed light on biophysical traits that had not been previously demonstrated. MDPI 2020-05-12 /pmc/articles/PMC7279265/ /pubmed/32408609 http://dx.doi.org/10.3390/ijms21103421 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Benítez-Angeles, Miguel
Morales-Lázaro, Sara Luz
Juárez-González, Emmanuel
Rosenbaum, Tamara
TRPV1: Structure, Endogenous Agonists, and Mechanisms
title TRPV1: Structure, Endogenous Agonists, and Mechanisms
title_full TRPV1: Structure, Endogenous Agonists, and Mechanisms
title_fullStr TRPV1: Structure, Endogenous Agonists, and Mechanisms
title_full_unstemmed TRPV1: Structure, Endogenous Agonists, and Mechanisms
title_short TRPV1: Structure, Endogenous Agonists, and Mechanisms
title_sort trpv1: structure, endogenous agonists, and mechanisms
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7279265/
https://www.ncbi.nlm.nih.gov/pubmed/32408609
http://dx.doi.org/10.3390/ijms21103421
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