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TRPV1: Structure, Endogenous Agonists, and Mechanisms
The Transient Receptor Potential Vanilloid 1 (TRPV1) channel is a polymodal protein with functions widely linked to the generation of pain. Several agonists of exogenous and endogenous nature have been described for this ion channel. Nonetheless, detailed mechanisms and description of binding sites...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7279265/ https://www.ncbi.nlm.nih.gov/pubmed/32408609 http://dx.doi.org/10.3390/ijms21103421 |
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author | Benítez-Angeles, Miguel Morales-Lázaro, Sara Luz Juárez-González, Emmanuel Rosenbaum, Tamara |
author_facet | Benítez-Angeles, Miguel Morales-Lázaro, Sara Luz Juárez-González, Emmanuel Rosenbaum, Tamara |
author_sort | Benítez-Angeles, Miguel |
collection | PubMed |
description | The Transient Receptor Potential Vanilloid 1 (TRPV1) channel is a polymodal protein with functions widely linked to the generation of pain. Several agonists of exogenous and endogenous nature have been described for this ion channel. Nonetheless, detailed mechanisms and description of binding sites have been resolved only for a few endogenous agonists. This review focuses on summarizing discoveries made in this particular field of study and highlighting the fact that studying the molecular details of activation of the channel by different agonists can shed light on biophysical traits that had not been previously demonstrated. |
format | Online Article Text |
id | pubmed-7279265 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-72792652020-06-15 TRPV1: Structure, Endogenous Agonists, and Mechanisms Benítez-Angeles, Miguel Morales-Lázaro, Sara Luz Juárez-González, Emmanuel Rosenbaum, Tamara Int J Mol Sci Review The Transient Receptor Potential Vanilloid 1 (TRPV1) channel is a polymodal protein with functions widely linked to the generation of pain. Several agonists of exogenous and endogenous nature have been described for this ion channel. Nonetheless, detailed mechanisms and description of binding sites have been resolved only for a few endogenous agonists. This review focuses on summarizing discoveries made in this particular field of study and highlighting the fact that studying the molecular details of activation of the channel by different agonists can shed light on biophysical traits that had not been previously demonstrated. MDPI 2020-05-12 /pmc/articles/PMC7279265/ /pubmed/32408609 http://dx.doi.org/10.3390/ijms21103421 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Benítez-Angeles, Miguel Morales-Lázaro, Sara Luz Juárez-González, Emmanuel Rosenbaum, Tamara TRPV1: Structure, Endogenous Agonists, and Mechanisms |
title | TRPV1: Structure, Endogenous Agonists, and Mechanisms |
title_full | TRPV1: Structure, Endogenous Agonists, and Mechanisms |
title_fullStr | TRPV1: Structure, Endogenous Agonists, and Mechanisms |
title_full_unstemmed | TRPV1: Structure, Endogenous Agonists, and Mechanisms |
title_short | TRPV1: Structure, Endogenous Agonists, and Mechanisms |
title_sort | trpv1: structure, endogenous agonists, and mechanisms |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7279265/ https://www.ncbi.nlm.nih.gov/pubmed/32408609 http://dx.doi.org/10.3390/ijms21103421 |
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