KRAB-Induced Heterochromatin Effectively Silences PLOD2 Gene Expression in Somatic Cells and Is Resilient to TGFβ1 Activation

Epigenetic editing, an emerging technique used for the modulation of gene expression in mammalian cells, is a promising strategy to correct disease-related gene expression. Although epigenetic reprogramming results in sustained transcriptional modulation in several in vivo models, further studies ar...

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Detalles Bibliográficos
Autores principales: Gjaltema, Rutger A. F., Goubert, Désirée, Huisman, Christian, del Pilar García Tobilla, Consuelo, Koncz, Mihály, Jellema, Pytrick G., Wu, Dandan, Brouwer, Uilke, Kiss, Antal, Verschure, Pernette J., Bank, Ruud A., Rots, Marianne G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7279273/
https://www.ncbi.nlm.nih.gov/pubmed/32455614
http://dx.doi.org/10.3390/ijms21103634

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