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The Role of Selected Chemokines and Their Receptors in the Development of Gliomas

Among heterogeneous primary tumors of the central nervous system (CNS), gliomas are the most frequent type, with glioblastoma multiforme (GBM) characterized with the worst prognosis. In their development, certain chemokine/receptor axes play important roles and promote proliferation, survival, metas...

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Autores principales: Groblewska, Magdalena, Litman-Zawadzka, Ala, Mroczko, Barbara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7279280/
https://www.ncbi.nlm.nih.gov/pubmed/32456359
http://dx.doi.org/10.3390/ijms21103704
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author Groblewska, Magdalena
Litman-Zawadzka, Ala
Mroczko, Barbara
author_facet Groblewska, Magdalena
Litman-Zawadzka, Ala
Mroczko, Barbara
author_sort Groblewska, Magdalena
collection PubMed
description Among heterogeneous primary tumors of the central nervous system (CNS), gliomas are the most frequent type, with glioblastoma multiforme (GBM) characterized with the worst prognosis. In their development, certain chemokine/receptor axes play important roles and promote proliferation, survival, metastasis, and neoangiogenesis. However, little is known about the significance of atypical receptors for chemokines (ACKRs) in these tumors. The objective of the study was to present the role of chemokines and their conventional and atypical receptors in CNS tumors. Therefore, we performed a thorough search for literature concerning our investigation via the PubMed database. We describe biological functions of chemokines/chemokine receptors from various groups and their significance in carcinogenesis, cancer-related inflammation, neo-angiogenesis, tumor growth, and metastasis. Furthermore, we discuss the role of chemokines in glioma development, with particular regard to their function in the transition from low-grade to high-grade tumors and angiogenic switch. We also depict various chemokine/receptor axes, such as CXCL8-CXCR1/2, CXCL12-CXCR4, CXCL16-CXCR6, CX3CL1-CX3CR1, CCL2-CCR2, and CCL5-CCR5 of special importance in gliomas, as well as atypical chemokine receptors ACKR1-4, CCRL2, and PITPMN3. Additionally, the diagnostic significance and usefulness of the measurement of some chemokines and their receptors in the blood and cerebrospinal fluid (CSF) of glioma patients is also presented.
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spelling pubmed-72792802020-06-15 The Role of Selected Chemokines and Their Receptors in the Development of Gliomas Groblewska, Magdalena Litman-Zawadzka, Ala Mroczko, Barbara Int J Mol Sci Review Among heterogeneous primary tumors of the central nervous system (CNS), gliomas are the most frequent type, with glioblastoma multiforme (GBM) characterized with the worst prognosis. In their development, certain chemokine/receptor axes play important roles and promote proliferation, survival, metastasis, and neoangiogenesis. However, little is known about the significance of atypical receptors for chemokines (ACKRs) in these tumors. The objective of the study was to present the role of chemokines and their conventional and atypical receptors in CNS tumors. Therefore, we performed a thorough search for literature concerning our investigation via the PubMed database. We describe biological functions of chemokines/chemokine receptors from various groups and their significance in carcinogenesis, cancer-related inflammation, neo-angiogenesis, tumor growth, and metastasis. Furthermore, we discuss the role of chemokines in glioma development, with particular regard to their function in the transition from low-grade to high-grade tumors and angiogenic switch. We also depict various chemokine/receptor axes, such as CXCL8-CXCR1/2, CXCL12-CXCR4, CXCL16-CXCR6, CX3CL1-CX3CR1, CCL2-CCR2, and CCL5-CCR5 of special importance in gliomas, as well as atypical chemokine receptors ACKR1-4, CCRL2, and PITPMN3. Additionally, the diagnostic significance and usefulness of the measurement of some chemokines and their receptors in the blood and cerebrospinal fluid (CSF) of glioma patients is also presented. MDPI 2020-05-24 /pmc/articles/PMC7279280/ /pubmed/32456359 http://dx.doi.org/10.3390/ijms21103704 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Groblewska, Magdalena
Litman-Zawadzka, Ala
Mroczko, Barbara
The Role of Selected Chemokines and Their Receptors in the Development of Gliomas
title The Role of Selected Chemokines and Their Receptors in the Development of Gliomas
title_full The Role of Selected Chemokines and Their Receptors in the Development of Gliomas
title_fullStr The Role of Selected Chemokines and Their Receptors in the Development of Gliomas
title_full_unstemmed The Role of Selected Chemokines and Their Receptors in the Development of Gliomas
title_short The Role of Selected Chemokines and Their Receptors in the Development of Gliomas
title_sort role of selected chemokines and their receptors in the development of gliomas
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7279280/
https://www.ncbi.nlm.nih.gov/pubmed/32456359
http://dx.doi.org/10.3390/ijms21103704
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