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Inherited Risk Factors of Thromboembolic Events in Patients with Primary Nephrotic Syndrome

Background and objectives. Venous thromboembolic events (VTEs) are among the most important complications of nephrotic syndrome (NS). We conducted a study that aimed to determine the prevalence of inherited risk factors for VTE in NS and to identify which factors are independent predictors of VTE. M...

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Autores principales: Ismail, Gener, Obrișcă, Bogdan, Jurubiță, Roxana, Andronesi, Andreea, Sorohan, Bogdan, Hârza, Mihai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7279319/
https://www.ncbi.nlm.nih.gov/pubmed/32438633
http://dx.doi.org/10.3390/medicina56050242
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author Ismail, Gener
Obrișcă, Bogdan
Jurubiță, Roxana
Andronesi, Andreea
Sorohan, Bogdan
Hârza, Mihai
author_facet Ismail, Gener
Obrișcă, Bogdan
Jurubiță, Roxana
Andronesi, Andreea
Sorohan, Bogdan
Hârza, Mihai
author_sort Ismail, Gener
collection PubMed
description Background and objectives. Venous thromboembolic events (VTEs) are among the most important complications of nephrotic syndrome (NS). We conducted a study that aimed to determine the prevalence of inherited risk factors for VTE in NS and to identify which factors are independent predictors of VTE. Materials and Methods. Thirty-six consecutive patients with primary NS that underwent percutaneous kidney biopsy between January 2017 and December 2017 were enrolled in this retrospective, observational study. VTEs were the primary outcome. Baseline demographic and biochemical data were collected from medical records, and genetic testing was done for polymorphisms of Factor V, PAI, MTHFR, and prothrombin genes. Results. The incidence of VTE was 28%, and the median time to event was 3 months (IQR: 2–9). The prevalence of inherited risk factors was 14% for Factor V Leiden mutation, 5.6% for prothrombin G20210A, 44.5% for PAI, and 27.8% for each of the two polymorphisms of the MTHFR gene. On multivariate analysis, the presence of at least two mutations was independently associated with the risk of VTE (HR, 8.92; 95% confidence interval, CI: 1.001 to 79.58, p = 0,05). Conclusions. These findings suggest that genetic testing for inherited thrombophilia in NS could play an important role in detecting high-risk patients that warrant prophylactic anticoagulation.
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spelling pubmed-72793192020-06-17 Inherited Risk Factors of Thromboembolic Events in Patients with Primary Nephrotic Syndrome Ismail, Gener Obrișcă, Bogdan Jurubiță, Roxana Andronesi, Andreea Sorohan, Bogdan Hârza, Mihai Medicina (Kaunas) Article Background and objectives. Venous thromboembolic events (VTEs) are among the most important complications of nephrotic syndrome (NS). We conducted a study that aimed to determine the prevalence of inherited risk factors for VTE in NS and to identify which factors are independent predictors of VTE. Materials and Methods. Thirty-six consecutive patients with primary NS that underwent percutaneous kidney biopsy between January 2017 and December 2017 were enrolled in this retrospective, observational study. VTEs were the primary outcome. Baseline demographic and biochemical data were collected from medical records, and genetic testing was done for polymorphisms of Factor V, PAI, MTHFR, and prothrombin genes. Results. The incidence of VTE was 28%, and the median time to event was 3 months (IQR: 2–9). The prevalence of inherited risk factors was 14% for Factor V Leiden mutation, 5.6% for prothrombin G20210A, 44.5% for PAI, and 27.8% for each of the two polymorphisms of the MTHFR gene. On multivariate analysis, the presence of at least two mutations was independently associated with the risk of VTE (HR, 8.92; 95% confidence interval, CI: 1.001 to 79.58, p = 0,05). Conclusions. These findings suggest that genetic testing for inherited thrombophilia in NS could play an important role in detecting high-risk patients that warrant prophylactic anticoagulation. MDPI 2020-05-19 /pmc/articles/PMC7279319/ /pubmed/32438633 http://dx.doi.org/10.3390/medicina56050242 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ismail, Gener
Obrișcă, Bogdan
Jurubiță, Roxana
Andronesi, Andreea
Sorohan, Bogdan
Hârza, Mihai
Inherited Risk Factors of Thromboembolic Events in Patients with Primary Nephrotic Syndrome
title Inherited Risk Factors of Thromboembolic Events in Patients with Primary Nephrotic Syndrome
title_full Inherited Risk Factors of Thromboembolic Events in Patients with Primary Nephrotic Syndrome
title_fullStr Inherited Risk Factors of Thromboembolic Events in Patients with Primary Nephrotic Syndrome
title_full_unstemmed Inherited Risk Factors of Thromboembolic Events in Patients with Primary Nephrotic Syndrome
title_short Inherited Risk Factors of Thromboembolic Events in Patients with Primary Nephrotic Syndrome
title_sort inherited risk factors of thromboembolic events in patients with primary nephrotic syndrome
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7279319/
https://www.ncbi.nlm.nih.gov/pubmed/32438633
http://dx.doi.org/10.3390/medicina56050242
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