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Clinical and Prognostic Significance of TZAP Expression in Cervical Cancer
Background and Objectives: Telomeric zinc finger-associated protein (TZAP) is a telomere-associated factor that was previously called ZBTB48. This protein binds preferentially to long telomeres, competing with telomeric repeat factors 1 and 2. Genetic changes in TZAP may be associated with cancer pa...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7279327/ https://www.ncbi.nlm.nih.gov/pubmed/32344888 http://dx.doi.org/10.3390/medicina56050207 |
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author | Park, Won-Jin Park, Jae-Hee Shin, Ho-Yong Lee, Jae-Ho |
author_facet | Park, Won-Jin Park, Jae-Hee Shin, Ho-Yong Lee, Jae-Ho |
author_sort | Park, Won-Jin |
collection | PubMed |
description | Background and Objectives: Telomeric zinc finger-associated protein (TZAP) is a telomere-associated factor that was previously called ZBTB48. This protein binds preferentially to long telomeres, competing with telomeric repeat factors 1 and 2. Genetic changes in TZAP may be associated with cancer pathogenesis; however, this relationship has not yet been elucidated for any type of cancer. In this study, we aimed to examine the clinicopathologic and prognostic value of TZAP expression in cervical cancer (CC). Materials and Methods: The data were extracted from The Cancer Genome Atlas cohorts by OncoLnc (21 cancer types, 7700 cancers). The prognostic value of TZAP for different stages of 264 CCs was examined using survival analysis. Results: The TZAP expression did not differ significantly between CC and normal matched tissues. Age, cancer stage, and viral infection were not associated with TZAP expression. Survival analysis revealed a shorter overall survival in CC patients with a lower TZAP expression (χ(2) = 3.62, p = 0.057). The prognostic value of TZAP expression was greater in patients with N1 stage CC (χ(2) = 5.64, p = 0.018). Conclusion: TZAP expression is a possible prognostic marker for CC, especially stage N1 CC. |
format | Online Article Text |
id | pubmed-7279327 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-72793272020-06-17 Clinical and Prognostic Significance of TZAP Expression in Cervical Cancer Park, Won-Jin Park, Jae-Hee Shin, Ho-Yong Lee, Jae-Ho Medicina (Kaunas) Article Background and Objectives: Telomeric zinc finger-associated protein (TZAP) is a telomere-associated factor that was previously called ZBTB48. This protein binds preferentially to long telomeres, competing with telomeric repeat factors 1 and 2. Genetic changes in TZAP may be associated with cancer pathogenesis; however, this relationship has not yet been elucidated for any type of cancer. In this study, we aimed to examine the clinicopathologic and prognostic value of TZAP expression in cervical cancer (CC). Materials and Methods: The data were extracted from The Cancer Genome Atlas cohorts by OncoLnc (21 cancer types, 7700 cancers). The prognostic value of TZAP for different stages of 264 CCs was examined using survival analysis. Results: The TZAP expression did not differ significantly between CC and normal matched tissues. Age, cancer stage, and viral infection were not associated with TZAP expression. Survival analysis revealed a shorter overall survival in CC patients with a lower TZAP expression (χ(2) = 3.62, p = 0.057). The prognostic value of TZAP expression was greater in patients with N1 stage CC (χ(2) = 5.64, p = 0.018). Conclusion: TZAP expression is a possible prognostic marker for CC, especially stage N1 CC. MDPI 2020-04-25 /pmc/articles/PMC7279327/ /pubmed/32344888 http://dx.doi.org/10.3390/medicina56050207 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Park, Won-Jin Park, Jae-Hee Shin, Ho-Yong Lee, Jae-Ho Clinical and Prognostic Significance of TZAP Expression in Cervical Cancer |
title | Clinical and Prognostic Significance of TZAP Expression in Cervical Cancer |
title_full | Clinical and Prognostic Significance of TZAP Expression in Cervical Cancer |
title_fullStr | Clinical and Prognostic Significance of TZAP Expression in Cervical Cancer |
title_full_unstemmed | Clinical and Prognostic Significance of TZAP Expression in Cervical Cancer |
title_short | Clinical and Prognostic Significance of TZAP Expression in Cervical Cancer |
title_sort | clinical and prognostic significance of tzap expression in cervical cancer |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7279327/ https://www.ncbi.nlm.nih.gov/pubmed/32344888 http://dx.doi.org/10.3390/medicina56050207 |
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