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Pharmacological Modulation of Steroid Activity in Hormone-Dependent Breast and Prostate Cancers: Effect of Some Plant Extract Derivatives

The great majority of breast and prostate tumors are hormone-dependent cancers; hence, estrogens and androgens can, respectively, drive their developments, making it possible to use pharmacological therapies in their hormone-dependent phases by targeting the levels of steroid or modulating their phy...

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Autores principales: Bayala, Bagora, Zoure, Abdou Azaque, Baron, Silvère, de Joussineau, Cyrille, Simpore, Jacques, Lobaccaro, Jean-Marc A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7279356/
https://www.ncbi.nlm.nih.gov/pubmed/32456259
http://dx.doi.org/10.3390/ijms21103690
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author Bayala, Bagora
Zoure, Abdou Azaque
Baron, Silvère
de Joussineau, Cyrille
Simpore, Jacques
Lobaccaro, Jean-Marc A.
author_facet Bayala, Bagora
Zoure, Abdou Azaque
Baron, Silvère
de Joussineau, Cyrille
Simpore, Jacques
Lobaccaro, Jean-Marc A.
author_sort Bayala, Bagora
collection PubMed
description The great majority of breast and prostate tumors are hormone-dependent cancers; hence, estrogens and androgens can, respectively, drive their developments, making it possible to use pharmacological therapies in their hormone-dependent phases by targeting the levels of steroid or modulating their physiological activity through their respective nuclear receptors when the tumors relapse. Unfortunately, at some stage, both breast and prostate cancers become resistant to pharmacological treatments that aim to block their receptors, estrogen (ER) or androgen (AR) receptors, respectively. So far, antiestrogens and antiandrogens used in clinics have been designed based on their structural analogies with natural hormones, 17-β estradiol and dihydrotestosterone. Plants are a potential source of drug discovery and the development of new pharmacological compounds. The aim of this review article is to highlight the recent advances in the pharmacological modulation of androgen or estrogen levels, and their activity through their cognate nuclear receptors in prostate or breast cancer and the effects of some plants extracts.
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spelling pubmed-72793562020-06-17 Pharmacological Modulation of Steroid Activity in Hormone-Dependent Breast and Prostate Cancers: Effect of Some Plant Extract Derivatives Bayala, Bagora Zoure, Abdou Azaque Baron, Silvère de Joussineau, Cyrille Simpore, Jacques Lobaccaro, Jean-Marc A. Int J Mol Sci Review The great majority of breast and prostate tumors are hormone-dependent cancers; hence, estrogens and androgens can, respectively, drive their developments, making it possible to use pharmacological therapies in their hormone-dependent phases by targeting the levels of steroid or modulating their physiological activity through their respective nuclear receptors when the tumors relapse. Unfortunately, at some stage, both breast and prostate cancers become resistant to pharmacological treatments that aim to block their receptors, estrogen (ER) or androgen (AR) receptors, respectively. So far, antiestrogens and antiandrogens used in clinics have been designed based on their structural analogies with natural hormones, 17-β estradiol and dihydrotestosterone. Plants are a potential source of drug discovery and the development of new pharmacological compounds. The aim of this review article is to highlight the recent advances in the pharmacological modulation of androgen or estrogen levels, and their activity through their cognate nuclear receptors in prostate or breast cancer and the effects of some plants extracts. MDPI 2020-05-23 /pmc/articles/PMC7279356/ /pubmed/32456259 http://dx.doi.org/10.3390/ijms21103690 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Bayala, Bagora
Zoure, Abdou Azaque
Baron, Silvère
de Joussineau, Cyrille
Simpore, Jacques
Lobaccaro, Jean-Marc A.
Pharmacological Modulation of Steroid Activity in Hormone-Dependent Breast and Prostate Cancers: Effect of Some Plant Extract Derivatives
title Pharmacological Modulation of Steroid Activity in Hormone-Dependent Breast and Prostate Cancers: Effect of Some Plant Extract Derivatives
title_full Pharmacological Modulation of Steroid Activity in Hormone-Dependent Breast and Prostate Cancers: Effect of Some Plant Extract Derivatives
title_fullStr Pharmacological Modulation of Steroid Activity in Hormone-Dependent Breast and Prostate Cancers: Effect of Some Plant Extract Derivatives
title_full_unstemmed Pharmacological Modulation of Steroid Activity in Hormone-Dependent Breast and Prostate Cancers: Effect of Some Plant Extract Derivatives
title_short Pharmacological Modulation of Steroid Activity in Hormone-Dependent Breast and Prostate Cancers: Effect of Some Plant Extract Derivatives
title_sort pharmacological modulation of steroid activity in hormone-dependent breast and prostate cancers: effect of some plant extract derivatives
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7279356/
https://www.ncbi.nlm.nih.gov/pubmed/32456259
http://dx.doi.org/10.3390/ijms21103690
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